The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., & Yoshimura, A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00446-6 · Cited by 630 · see citing works

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O., & Akira, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.184 · Cited by 135 · see citing works

LPS/TLR4 signal transduction pathway

Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works

The history of toll-like receptors - redefining innate immunity

O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3446 · Cited by 1,765 · see citing works

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works

The IRF Family Transcription Factors in Immunity and Oncogenesis

Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works

Helical Assembly in the MyD88-IRAK4-IRAK2 Complex in TLR/IL-1R Signalling

Lin, S.-C., Lo, Y.-C., & Wu, H. (2010) · Nature · doi:10.1038/nature09121 · Cited by 1,111 · see citing works

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944 · see citing works

Assembly and localization of Toll-like receptor signalling complexes

Gay, N. J., Symmons, M. F., Gangloff, M., & Bryant, C. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3713 · Cited by 832 · see citing works

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis

Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S. P., Belkaid, Y., & Merad, M. (2014) · Science · doi:10.1126/science.1249288 · Cited by 820 · see citing works

Toll‐like receptors and adaptor molecules in liver disease: Update†

Seki, E., & Brenner, D. A. (2008) · Hepatology · doi:10.1002/hep.22306 · Cited by 722 · see citing works

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S., & Mócsai, A. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.034 · Cited by 642 · see citing works

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.036 · Cited by 592 · see citing works

Toll-like receptors — taking an evolutionary approach

Leulier, F., & Lemaitre, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2303 · Cited by 581 · see citing works

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

Broz, P., Ruby, T., Belhocine, K., Bouley, D. M., Kayagaki, N., Dixit, V. M., & Monack, D. M. (2012) · Nature · doi:10.1038/nature11419 · Cited by 535 · see citing works

Use of defined TLR ligands as adjuvants within human vaccines

Duthie, M. S., Windish, H. P., Fox, C. B., & Reed, S. G. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00978.x · Cited by 437 · see citing works

The critical role of toll‐like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88†

Hritz, I., Mandrekar, P., Velayudham, A., Catalano, D., Dolganiuc, A., Kodys, K., Kurt‐Jones, E., & Szabo, G. (2008) · Hepatology · doi:10.1002/hep.22470 · Cited by 415 · see citing works

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

Shi, C.-S., & Kehrl, J. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804478200 · Cited by 395 · see citing works

The molecular basis of the host response to lipopolysaccharide

Bryant, C. E., Spring, D. R., Gangloff, M., & Gay, N. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2266 · Cited by 391 · see citing works

Critical role of TLR4 response in the activation of microglia induced by ethanol

Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373 · see citing works

The emerging role of Toll-like receptor 4 in myocardial inflammation

Yang, Y., Lv, J., Jiang, S., Ma, Z., Wang, D., Hu, W., Deng, C., Fan, C., Di, S., Sun, Y., et al. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.140 · Cited by 337 · see citing works

Toll-like receptors in the pathogenesis of neuroinflammation

Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331 · see citing works

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

Cheng, N., He, R., Tian, J., Ye, P. P., & Ye, R. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.22 · Cited by 284 · see citing works

The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation

Kim, J.-H., Na, H.-J., Kim, C.-K., Kim, J.-Y., Ha, K.-S., Lee, H., Chung, H.-T., Kwon, H. J., Kwon, Y.-G., & Kim, Y.-M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.019 · Cited by 273 · see citing works

Trial watch: TLR3 agonists in cancer therapy

Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G., & Vacchelli, E. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771143 · Cited by 239 · see citing works

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

Chéret, C., Gervais, A., Lelli, A., Colin, C., Amar, L., Ravassard, P., Mallet, J., Cumano, A., Krause, K.-H., & Mallat, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3568-08.2008 · Cited by 225 · see citing works

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202 · see citing works

The microbiology of asthma

Edwards, M. R., Bartlett, N. W., Hussell, T., Openshaw, P., & Johnston, S. L. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2801 · Cited by 205 · see citing works

Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?

van Die, I., & Cummings, R. D. (2010) · Glycobiology · doi:10.1093/glycob/cwp140 · Cited by 199 · see citing works

Targeting the TLR9–MyD88 pathway in the regulation of adaptive immune responses

Huang, X., & Yang, Y. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.501333 · Cited by 121 · see citing works

Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals

Tacchini, L., Gammella, E., De Ponti, C., Recalcati, S., & Cairo, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800365200 · Cited by 132 · see citing works

Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses

Béland, L.-C., Markovinovic, A., Jakovac, H., De Marchi, F., Bilic, E., Mazzini, L., Kriz, J., & Munitic, I. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa124 · Cited by 125 · see citing works

A role for IL‐18 in protective immunity against <i>Mycobacterium tuberculosis</i>

Schneider, B. E., Korbel, D., Hagens, K., Koch, M., Raupach, B., Enders, J., Kaufmann, S. H. E., Mittrücker, H., & Schaible, U. E. (2010) · European Journal of Immunology · doi:10.1002/eji.200939583 · Cited by 115 · see citing works

RNA Mediated toll-like receptor stimulation in health and disease

Dalpke, A. H., & Helm, M. (2012) · RNA Biology · doi:10.4161/rna.20206 · Cited by 113 · see citing works

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

Jantsch, J., Wiese, M., Schödel, J., Castiglione, K., Gläsner, J., Kolbe, S., Mole, D., Schleicher, U., Eckardt, K.-U., Hensel, M., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1210683 · Cited by 108 · see citing works

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications

Frega, G., Wu, Q., Le Naour, J., Vacchelli, E., Galluzzi, L., Kroemer, G., & Kepp, O. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1796002 · Cited by 108 · see citing works

Activation of toll-like receptor signaling pathways leading to nitric oxide-mediated antiviral responses

Abdul-Cader, M. S., Amarasinghe, A., & Abdul-Careem, M. F. (2016) · Archives of Virology · doi:10.1007/s00705-016-2904-x · Cited by 99 · see citing works

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: <i>In Vitro</i> Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages

Yamazaki, H., Kushiyama, A., Sakoda, H., Fujishiro, M., Yamamotoya, T., Nakatsu, Y., Kikuchi, T., Kaneko, S., Tanaka, H., & Asano, T. (2018) · Mediators of Inflammation · doi:10.1155/2018/3062319 · Cited by 86 · see citing works

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance

Sachithanandan, N., Graham, K. L., Galic, S., Honeyman, J. E., Fynch, S. L., Hewitt, K. A., Steinberg, G. R., & Kay, T. W. (2011) · Diabetes · doi:10.2337/db11-0259 · Cited by 81 · see citing works

Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

Aki, D., Minoda, Y., Yoshida, H., Watanabe, S., Yoshida, R., Takaesu, G., Chinen, T., Inaba, T., Hikida, M., Kurosaki, T., et al. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01159.x · Cited by 68 · see citing works

Particulate Matter and Its Molecular Effects on Skin: Implications for Various Skin Diseases

Paik, K., Na, J.-I., Huh, C.-H., & Shin, J.-W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189888 · Cited by 64 · see citing works

RING-Domain E3 Ligase-Mediated Host–Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses

Zhang, Y., Li, L.-F., Munir, M., & Qiu, H.-J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01083 · Cited by 62 · see citing works

Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis

Plantinga, T. S., Hamza, O. J. M., Willment, J. A., Ferwerda, B., van de Geer, N. M. D., Verweij, P. E., Matee, M. I. N., Banahan, K., O'Neill, L. A. J., Kullberg, B.-J., et al. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181e53c64 · Cited by 53 · see citing works

Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?

Wang, Y., Jia, J., Wang, Y., Li, F., Song, X., Qin, S., Wang, Z., Kitazato, K., & Wang, Y. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1660615 · Cited by 40 · see citing works

Regnase-1, a ribonuclease involved in the regulation of immune responses

Akira, S. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.019877 · Cited by 37 · see citing works

The Role of Toll-Like Receptors in Osteoclastogenesis

Yim, M. (2020) · Journal of Bone Metabolism · doi:10.11005/jbm.2020.27.4.227 · Cited by 28 · see citing works

B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation

Ferreira-Gomes, M., Wich, M., Böde, S., Hube, B., Jacobsen, I. D., & Jungnickel, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698849 · Cited by 29 · see citing works

Immunobiotic strains modulate Toll-like receptor 3 agonist induced innate antiviral immune response in human intestinal epithelial cells by modulating IFN regulatory factor 3 and NF-κB signaling

Kanmani, P., & Kim, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01536 · Cited by 21 · see citing works

Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality

Bartens, M.-C., Gibson, A. J., Etherington, G. J., Di Palma, F., Holder, A., Werling, D., & Willcocks, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.764390 · Cited by 19 · see citing works

Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation

Zhang, Z.-H., Liu, X.-Q., Zhang, C., He, W., Wang, H., Chen, Y.-H., Liu, X.-J., Chen, X., & Xu, D.-X. (2016) · Scientific Reports · doi:10.1038/srep33513 · Cited by 18 · see citing works

Cortisol is a potent modulator of lipopolysaccharide-induced interferon signaling in macrophages

Billing, A. M., Fack, F., Turner, J. D., & Muller, C. P. (2011) · Innate Immunity · doi:10.1177/1753425910369269 · Cited by 15 · see citing works