Effects of lorazepam and its withdrawal on sleep, performance, and subjective state
Abstract
The effects of 3 mg lorazepam on polysomnographic recordings, performance, anxiety, and perceived sleep were examined. Six insomniac subjects slept in the sleep laboratory for 18 consecutive nights after having taken placebo or lorazepam. Polysomnographic data and subjective reports indicated hypnotic efficacy in terms of sleep initiation and maintenance. There was some evidence of rebound insomnia after drug withdrawal, although it was not evident from all measures. Clear performance decrements occurred during lorazepam use.
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The prevalence of rebound insomnia is significantly lower in all benzodiazepines compared to triazolam.
“The prevalence of rebound insomnia was found to be significantly lower in all benzodiazepines compared to triazolam [52, 60-69] and was lower than that with triazolam.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [61]
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- Authors
- Walsh, J. K., Schweitzer, P. K., & Parwatikar, S.
- Affiliations
- Deaconess Hospital (US)
- Corresponding author
- Walsh, James K
- ORCID
- Schweitzer, Paula K
- Venue
- Clinical Pharmacology and Therapeutics
- Publisher
- Wiley
- Published
- 1983-10
- Volume
- 34
- Issue
- 4
- Pages
- 496-500
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W1974682667
- Cited by
- 24
- References
- 0
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- lorazepam, benzodiazepines, drug withdrawal, rebound insomnia, insomnia, hypnotic efficacy, sleep maintenance, sleep initiation, cognitive performance, anxiety, subjective sleep quality, polysomnography
- MeSH terms
- Adult, Anxiety, Female, Humans, Sleep Initiation and Maintenance Disorders, Lorazepam, Male, Psychomotor Performance, Sleep Stages, Substance Withdrawal Syndrome
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