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Cited by 49Sleep and related disordersSleep and Wakefulness ResearchTreatment of Major Depression

Differential effects of amitriptyline and of zimelidine on the sleep electroencephalogram of depressed patients

Shipley, James E, Kupfer, David J, Dealy, Robert S, Griffin, Suzanne J, Coble, Patricia A, McEachran, Ann B, Grochocinski, Victoria J·1984·Clinical Pharmacology and Therapeutics
DOI 10.1038/clpt.1984.171
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Abstract

The effects of amitriptyline (n = 14) or zimelidine (n = 13) on the sleep electroencephalogram of hospitalized depressed patients were assessed in a double-blind protocol involving 28 days of active dosing. Zimelidine induced no immediate improvement in sleep continuity, and even after 3 wk on zimelidine subjects tended to have longer sleep latency, more awakenings, and lighter non-rapid eye movement (REM) sleep than before taking the drug. Zimelidine did, however, induce a rapid and persistent alteration of sleep architecture and selected REM measures. REM sleep, which was suppressed over the first two nights on zimelidine, was maximally suppressed after 1 wk, but by 3 wk there was some tolerance for selected REM measures. While zimelidine induced none of the sedative effects of amitriptyline, both were equivalent in their REM-suppressant effects. These findings are discussed in terms of the differences in uptake blockade and anticholinergic potency in these two drugs.

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  • Certain TCAs, including amitriptyline and trimipramine, shorten sleep onset latency, improve sleep continuity or sleep efficiency, and decrease wake time after sleep onset (WASO).

    “Consistent with clinical experience, certain TCAs, including amitriptyline and trimipramine, are reported to shorten sleep onset latency, improve sleep continuity or sleep efficiency (the proportion of time in bed during which the subject is actually recorded asleep), and decrease wake time after sleep onset (WASO) [Kupfer, 1982;Shipley et al., 1984;Ware et al., 1989].”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Shipley et al., 1984

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Authors
Shipley, J. E., Kupfer, D. J., Dealy, R. S., Griffin, S. J., Coble, P. A., McEachran, A. B., & Grochocinski, V. J.
Affiliations
University of Pittsburgh (US)
Corresponding author
Shipley, James E
ORCID
Kupfer, David J
Venue
Clinical Pharmacology and Therapeutics
Publisher
Wiley
Published
1984-08
Volume
36
Issue
2
Pages
251-259
ISSN
  • 0009-9236 (ISSN-L)
  • 1532-6535
DOI
10.1038/clpt.1984.171
OpenAlex
W2099012332
Cited by
49
References
0
Citations by year
2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2013: 1
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
amitriptyline, zimelidine, depression, sleep EEG, REM sleep suppression, sleep architecture, sleep latency, sleep continuity, antidepressant side effects, tricyclic antidepressants, drug tolerance
MeSH terms
Adult, Amitriptyline, Depressive Disorder, Electroencephalography, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep, REM, Zimeldine

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