The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics
Open accessAbstract
Infection and inflammation are associated with downregulation of hepatic and extrahepatic cytochrome P450s as well as other drug-metabolizing enzymes and transporters. We review the genesis of inflammatory reactions and discuss the relevance of the inflammation-related regulation of cytochrome P450 enzymes to clinical drug–disease and drug–drug interactions. An understanding of the enzyme specificity and mechanisms of regulation will allow us to make better decisions about adjusting drug dosage regimens when a patient's inflammatory status changes. Clinical Pharmacology & Therapeutics (2009); 85, 4, 434–438 doi:10.1038/clpt.2008.302
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Cites
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178
REGULATION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN INFLAMMATION
Aitken, A. E., Richardson, T. A., & Morgan, E. T. (2006) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141059 · Cited by 448
Self-citationAh Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity
Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., & Gallo, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.510 · Cited by 405
Zhou, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26283 · Cited by 402
Aitken, A. E., & Morgan, E. T. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.015511 · Cited by 398
Self-citationRegulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer
Morgan, E. T., Goralski, K. B., Piquette-Miller, M., Renton, K. W., Robertson, G. R., Chaluvadi, M. R., Charles, K. A., Clarke, S. J., Kacevska, M., Liddle, C., et al. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.018747 · Cited by 395
Self-citationRole of NF-κB in Regulation of PXR-mediated Gene Expression
Gu, X., Ke, S., Liu, D., Sheng, T., Thomas, P. E., Rabson, A. B., Gallo, M. A., Xie, W., & Tian, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601302200 · Cited by 310
Jover, R., Bort, R., Gómez‐Lechón, M. J., & Castell, J. V. (2002) · The FASEB Journal · doi:10.1096/fj.02-0195fje · Cited by 221
Altered Theophylline Clearance During an Influenza B Outbreak
Kraemer, M. J., Furukawa, C. T., Koup, J. R., Shapiro, G. G., Pierson, W. E., & Bierman, C. W. (1982) · Pediatrics · doi:10.1542/peds.69.4.476 · Cited by 199
Cited by
Organotypic liver culture models: meeting current challenges in toxicity testing
LeCluyse, E. L., Witek, R. P., Andersen, M. E., & Powers, M. J. (2012) · Critical Reviews in Toxicology · doi:10.3109/10408444.2012.682115 · Cited by 363
Rose, K. A., Holman, N. S., Green, A. M., Andersen, M. E., & LeCluyse, E. L. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/s0022-3549(15)00192-6 · Cited by 99
Towards improved hepatocyte cultures: Progress and limitations
Ruoß, M., Vosough, M., Königsrainer, A., Nadalin, S., Wagner, S., Sajadian, S., Huber, D., Heydari, Z., Ehnert, S., Hengstler, J. G., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111188 · Cited by 77
Li, F., Cao, L., Parikh, S., & Zuo, R. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.02.021 · Cited by 72
Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance
Rao, L. K., Flaker, A. M., Friedel, C. C., & Kharasch, E. D. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001392 · Cited by 67
Metadata
- Authors
- Morgan, E.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2009-02-11
- Volume
- 85
- Issue
- 4
- Pages
- 434-438
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2035610264
- Cited by
- 462
- References
- 27
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
