The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
REGULATION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN INFLAMMATION
Abstract
▪ Abstract Inflammation and infection have long been known to downregulate the activity and expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This can result in elevated plasma drug levels and increased adverse effects. Recent information on regulation of human CYP enzymes is presented, as are new developments in our understanding of the mechanisms of regulation. Experiments to study the effects of modulating CYP activities on the inflammatory response have yielded possible insights into the physiological consequences, if not the purpose, of the downregulation. Regulation of hepatic flavin monooxygenases, UDP-glucuronosyltransferases, sulfotransferases, glutathione S-transferases, as well as of hepatic transporters during the inflammatory response, exhibits similarities and differences with regulation of CYPs.
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Oxygen Activation by Cytochrome P-4501
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Molecular Pathogenesis of Cholestasis
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Molecular Pathogenesis of Cholestasis
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Regulation of Cytochromes P450 During Inflammation and Infection
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Cited by
Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
Zanger, U. M., Turpeinen, M., Klein, K., & Schwab, M. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2291-6 · Cited by 593
Pan, C., Kumar, C., Bohl, S., Klingmueller, U., & Mann, M. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800258-mcp200 · Cited by 561
“These enzymes are mainly involved in metabolizing endogenous substances and xenobiotics (24), a prototypical”
BackgroundMorgan, E. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.302 · Cited by 462
Self-citationAitken, A. E., & Morgan, E. T. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.015511 · Cited by 398
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Metadata
- Authors
- Aitken, A. E., Richardson, T. A., & Morgan, E. T.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 46
- Issue
- 1
- Pages
- 123-149
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2044634578
- Cited by
- 448
- References
- 132
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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