The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity
Open accessAbstract
The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife. NF-kappaB is a pleiotropic transcription factor controlling many physiological functions adversely affected by PAHs, including immune suppression, thymus involution, hyperkeratosis, and carcinogenesis. Here, we show physical interaction and mutual functional repression between AhR and NF-kappaB. This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that regulate NF-kappaB.
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Cites
Function and Activation of NF-kappaB in the Immune System
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DNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068
Cited by
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
Morgan, E. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.302 · Cited by 462
Ah receptor: Dioxin-mediated toxic responses as hints to deregulated physiologic functions
Bock, K. W., & Köhle, C. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.01.017 · Cited by 337
Metadata
- Authors
- Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., & Gallo, M. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 1
- Pages
- 510-515
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1998573431
- Cited by
- 405
- References
- 4
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., & Gallo, M. A. (1999). Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.1.510
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