The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Obesity, Inflammation, and Cardiovascular Risk
Abstract
Obesity, a highly prevalent condition, is heterogeneous with regard to its impact on cardiovascular disease (CVD) risk. Epidemiological observations and metabolic investigations have consistently demonstrated that the accumulation of excess visceral fat is related to an increased risk of CVD as well as several metabolic and inflammatory perturbations. In the past decade, data from several studies have served to emphasize that atherosclerosis has an inflammatory component that may contribute to several key pathophysiological processes. Study data have also highlighted the finding that the expanded visceral fat is infiltrated by macrophages that conduct "cross-talk" with adipose tissue through several significant mechanisms. In this review, we provide, in the context of CVD risk, an up-to-date account of the complex interactions that occur between a dysfunctional adipose tissue phenotype and inflammation.
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Citations
Cites
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
Self-citationEffects of torcetrapib in patients at high risk for coronary events
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Inflammation in Atherosclerosis
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Novel Modulator for Endothelial Adhesion Molecules: Adipocyte-Derived Plasma Protein Adiponectin
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Cited by
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Kapellos, T. S., Bonaguro, L., Gemünd, I., Reusch, N., Saglam, A., Hinkley, E. R., & Schultze, J. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02035 · Cited by 890
Parainflammation, Chronic Inflammation and Age-Related Macular Degeneration
Chen, M., & Xu, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0615-239r · Cited by 381
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Rosenblat, J., & McIntyre, R. (2017) · Brain Sciences · doi:10.3390/brainsci7110144 · Cited by 258
Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ
Wang, F., Mullican, S. E., DiSpirito, J. R., Peed, L. C., & Lazar, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314863110 · Cited by 255
Metadata
- Authors
- Mathieu, P., Lemieux, I., & Després, J.-P.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2010-03-03
- Volume
- 87
- Issue
- 4
- Pages
- 407-416
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2089354656
- Cited by
- 419
- References
- 54
- FWCI
- 28.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
