The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Obesity, adiponectin and vascular inflammatory disease
Abstract
PURPOSE OF REVIEW: Obesity is the most common risk factor for cardiovascular diseases in industrial countries. It is now clear that adipose tissue secretes various bioactive substances, conceptualized as adipocytokines, and that dysregulation of adipocytokines directly contributes to obesity-related diseases. Chronic inflammatory processes contribute to the development of atherosclerosis. In this review, the authors focus on the relationship between adiponectin, a recently discovered anti-atherogenic adipocytokine, and vascular inflammation. RECENT FINDINGS: Plasma concentrations of adiponectin, an adipocyte-specific protein, are reduced in obese subjects and in patients with type 2 diabetes and coronary artery disease. Adiponectin inhibits the expression of tumor necrosis factor-alpha-induced endothelial adhesion molecules, macrophage-to-foam cell transformation, tumor necrosis factor-alpha expression in macrophages and adipose tissues, and smooth muscle cell proliferation. In addition, adenovirus-expressed adiponectin reduces atherosclerotic lesions in a mouse model of atherosclerosis, and adiponectin-deficient mice exhibit an excessive vascular remodeling response to injury. Clinically, hypoadiponectinemia is closely associated with increased levels of inflammatory markers such as C-reactive protein and interleukin-6. SUMMARY: Adiponectin acts as an anti-inflammatory and anti-atherogenic plasma protein. Adiponectin is an endogenous biologically relevant modulator of vascular remodeling linking obesity and vascular disease.
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Cites
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Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
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Self-citationThe adipocyte-secreted protein Acrp30 enhances hepatic insulin action
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Self-citationWeight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
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Association between adiponectin and mediators of inflammation in obese women
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Cited by
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Self-citationInflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113
Obesity, Metabolic Syndrome, and Cardiovascular Disease
Grundy, S. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0372 · Cited by 1,371
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Metadata
- Authors
- Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., & Walsh, K.
- Venue
- Current Opinion in Lipidology
- Published
- 2003-12
- Volume
- 14
- Issue
- 6
- Pages
- 561-566
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2030611470
- Cited by
- 740
- References
- 8
- FWCI
- 26.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., & Walsh, K. (2003). Obesity, adiponectin and vascular inflammatory disease. Current Opinion in Lipidology. https://doi.org/10.1097/00041433-200312000-00003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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