The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ
Open accessAbstract
Significance: Obesity, due to increased adipose (fat) tissue, predisposes to metabolic diseases, including diabetes. Thus, it is important to understand adipose development and function. Peroxisome proliferator-activated receptor gamma (PPARγ) is widely believed to be the master regulator of adipocyte biology. Surprisingly, however, previous studies attempting to delete the PPARγ gene specifically in mouse adipose tissue did not demonstrate a dramatic phenotype. By using newer methods, the present study reports that fat-specific loss of PPARγ causes dramatic loss of adipose tissue, severe insulin resistance and diabetes, fatty liver, and abnormalities of bone, skin, and mammary glands, all of which contain adipose tissue. We show that adipocyte PPARγ is required for normal fat development and metabolic function in vivo.
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Cites
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“Adipose tissue also produces various adipokines, which regulate physiology at multiple levels (1).”
BackgroundPPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,079
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Cited by
Adipogenesis and metabolic health
Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395
PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD
Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778
Contribution of adipogenesis to healthy adipose tissue expansion in obesity
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Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
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Self-citationAdipose-derived and bone marrow mesenchymal stem cells: A donor-matched comparison
Mohamed-Ahmed, S., Fristad, I., Lie, S. A., Suliman, S., Mustafa, K., Vindenes, H., & Idris, S. B. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0914-1 · Cited by 515
Metadata
- Authors
- Wang, F., Mullican, S. E., DiSpirito, J. R., Peed, L. C., & Lazar, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-28
- Volume
- 110
- Issue
- 46
- Pages
- 18656-18661
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035559736
- Cited by
- 255
- References
- 48
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, F., Mullican, S. E., DiSpirito, J. R., Peed, L. C., & Lazar, M. A. (2013). Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1314863110
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