The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Regulation of NF-κB signaling by the A20 deubiquitinase
Open accessAbstract
The NF-κB transcription factor is a central mediator of inflammatory and innate immune signaling pathways. Activation of NF-κB is achieved by K63-linked polyubiquitination of key signaling molecules which recruit kinase complexes that in turn activate the IκB kinase (IKK). Ubiquitination is a highly dynamic process and is balanced by deubiquitinases that cleave polyubiquitin chains and terminate downstream signaling events. The A20 deubiquitinase is a critical negative regulator of NF-κB and inflammation, since A20-deficient mice develop uncontrolled and spontaneous multi-organ inflammation. Furthermore, specific polymorphisms in the A20 genomic locus predispose humans to autoimmune disease. Recent studies also indicate that A20 is an important tumor suppressor that is inactivated in B-cell lymphomas. Therefore, targeting A20 may form the basis of novel therapies for autoimmune disease and lymphomas.
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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
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Cited by
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585
Deubiquitylases From Genes to Organism
Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013) · Physiological Reviews · doi:10.1152/physrev.00002.2013 · Cited by 425
NF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383
Duong, B. H., Onizawa, M., Oses-Prieto, J. A., Advincula, R., Burlingame, A., Malynn, B. A., & Ma, A. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.031 · Cited by 273
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling
Garg, A. V., Ahmed, M., Vallejo, A. N., Ma, A., & Gaffen, S. L. (2013) · Science Signaling · doi:10.1126/scisignal.2003699 · Cited by 128
Metadata
- Authors
- Shembade, N., & Harhaj, E. W.
- Venue
- Cellular & Molecular Immunology
- Published
- 2012-02-20
- Volume
- 9
- Issue
- 2
- Pages
- 123-130
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- OpenAlex
- W2034236127
- Cited by
- 211
- References
- 10
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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