Human allograft rejection in humanized mice: a historical perspective
Open accessAbstract
Basic research in transplantation immunology has relied primarily on rodent models. Experimentation with rodents has laid the foundation for our basic understanding of the biological events that precipitate rejection of non-self or allogeneic tissue transplants and supported the development of novel strategies to specifically suppress allogeneic immune responses. However, translation of these studies to the clinic has met with limited success, emphasizing the need for new models that focus on human immune responses to allogeneic tissues. Humanized mouse models are an exciting alternative that permits investigation of the rejection of human tissues mediated by human immune cells without putting patients at risk. However, the use of humanized mice is complicated by a diversity of protocols and approaches, including the large number of immunodeficient mouse strains available, the choice of tissue to transplant and the specific human immune cell populations that can be engrafted. Here, we present a historical perspective on the study of allograft rejection in humanized mice and discuss the use of these novel model systems in transplant biology.
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NSG mice were chosen because of their ability to engraft skin at very high levels and perivascular infiltration of immune cells.
“NSG mice were chosen because of their ability to engraft skin at very high levels and perivascular infiltration of immune cells.”
From Single-cell transcriptomics of human-skin-equivalent organoids (2023) · cites this paper as [53]
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HUMAN PERIPHERAL BLOOD LYMPHOCYTE RECONSTITUTED SEVERE COMBINED IMMUNODEFICIENT (hu-PBL-SCID) MICE
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Islet Transplantation as a Treatment for Diabetes
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Humanized Mouse Models of Clinical Disease
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Humanized mice as a model to study human immunity
Heuts, F. W. H. (2012) · Figshare
Monterosso, M. E. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.236375
- Authors
- Brehm, M. A., & Shultz, L. D.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Jackson Laboratory (US)
- Corresponding author
- Brehm, Michael A
- Venue
- Cellular & Molecular Immunology
- Published
- 2012-02-13
- Volume
- 9
- Issue
- 3
- Pages
- 225-231
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC4012846
- OpenAlex
- W1979856058
- Cited by
- 30
- References
- 103
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Heart, Lung, and Blood Institute (R01HL077642, HL 077642)
- National Cancer Institute (#CA34196, P30CA034196)
- National Institute of Allergy and Infectious Diseases (AI46629, P01AI046629, P30AI042845)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK089572, U01DK089572, DK 32520, P30DK032520)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Keywords
- allograft rejection, humanized mice, transplantation immunology, human immune cells, xenotransplantation
- MeSH terms
- Animals, Disease Models, Animal, Graft Rejection, Humans, Mice, Mutant Strains, Organ Transplantation, Mice, SCID, Mice, Translational Research, Biomedical
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