Cited by 30Transplantation: Methods and OutcomesOrgan and Tissue Transplantation ResearchXenotransplantation and immune response

Human allograft rejection in humanized mice: a historical perspective

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Brehm, Michael A, Shultz, Leonard D·2012·Cellular & Molecular Immunology

Abstract

Basic research in transplantation immunology has relied primarily on rodent models. Experimentation with rodents has laid the foundation for our basic understanding of the biological events that precipitate rejection of non-self or allogeneic tissue transplants and supported the development of novel strategies to specifically suppress allogeneic immune responses. However, translation of these studies to the clinic has met with limited success, emphasizing the need for new models that focus on human immune responses to allogeneic tissues. Humanized mouse models are an exciting alternative that permits investigation of the rejection of human tissues mediated by human immune cells without putting patients at risk. However, the use of humanized mice is complicated by a diversity of protocols and approaches, including the large number of immunodeficient mouse strains available, the choice of tissue to transplant and the specific human immune cell populations that can be engrafted. Here, we present a historical perspective on the study of allograft rejection in humanized mice and discuss the use of these novel model systems in transplant biology.

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Crossref · 10.1038/cmi.2011.64

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  • NSG mice were chosen because of their ability to engraft skin at very high levels and perivascular infiltration of immune cells.

    “NSG mice were chosen because of their ability to engraft skin at very high levels and perivascular infiltration of immune cells.”

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Authors
Brehm, M. A., & Shultz, L. D.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • Jackson Laboratory (US)
Corresponding author
Brehm, Michael A
Venue
Cellular & Molecular Immunology
Published
2012-02-13
Volume
9
Issue
3
Pages
225-231
ISSN
  • 1672-7681 (ISSN-L)
  • 2042-0226
OpenAlex
W1979856058
Cited by
30
References
103
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 1 · 2012: 1
FWCI
0.87
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Immunology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders
  • National Institute for Health and Care Research
  • National Institutes of Health
  • Center for AIDS Research, University of Washington
  • National Heart, Lung, and Blood Institute (R01HL077642, HL 077642)
  • National Cancer Institute (#CA34196, P30CA034196)
  • National Institute of Allergy and Infectious Diseases (AI46629, P01AI046629, P30AI042845)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK089572, U01DK089572, DK 32520, P30DK032520)
Topics
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
  • Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
Keywords
allograft rejection, humanized mice, transplantation immunology, human immune cells, xenotransplantation
MeSH terms
Animals, Disease Models, Animal, Graft Rejection, Humans, Mice, Mutant Strains, Organ Transplantation, Mice, SCID, Mice, Translational Research, Biomedical

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