Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
Open accessAbstract
Interleukin (IL) 1α produced by human endothelial cells (ECs), in response to tumor necrosis factor (TNF) or to co-culture with allogeneic T cells in a TNF-dependent manner, can augment the release of cytokines from alloreactive memory T cells in vitro. In a human–mouse chimeric model of artery allograft rejection, ECs lining the transplanted human arteries express IL-1α, and blocking IL-1 reduces the extent of human T cell infiltration into the artery intima and selectively inhibits IL-17 production by infiltrating T cells. In human skin grafts implanted on immunodeficient mice, administration of IL-17 is sufficient to induce mild inflammation. In cultured cells, IL-17 acts preferentially on vascular smooth muscle cells rather than ECs to enhance production of proinflammatory mediators, including IL-6, CXCL8, and CCL20. Neutralization of IL-17 does not reduce T cell infiltration into allogeneic human artery grafts, but markedly reduces IL-6, CXCL8, and CCL20 expression and selectively inhibits CCR6+ T cell accumulation in rejecting arteries. We conclude that graft-derived IL-1 can promote T cell intimal recruitment and IL-17 production during human artery allograft rejection, and suggest that targeting IL-1 in the perioperative transplant period may modulate host alloreactivity.
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IL-1α release from injured endothelial cells promotes allogeneic T cell infiltration in a mouse-human chimeric model of artery allograft rejection.
“In the case of IL-1α, its release from injured endothelial cells promotes allogeneic T cell infiltration in a mouse–human chimeric model of artery allograft rejection76.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [76]
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Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works
Biologic basis for interleukin-1 in disease.
Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 3,380 · see citing works
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works
The Banff 97 working classification of renal allograft pathology
Racusen, L. C., Solez, K., Colvin, R. B., Bonsib, S. M., de Castro, M. C. R., Cavallo, T., Croker, B. P., Demetris, A. J., Drachenberg, C. B., Fogo, A. B., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00299.x · Cited by 3,026 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842 · see citing works
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828 · see citing works
Increased expression of interleukin 17 in inflammatory bowel disease
Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713 · see citing works
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,698 · see citing works
Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,669 · see citing works
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
Yen, D., Cheung, J., Scheerens, H., Poulet, F. M., McClanahan, T. K., McKenzie, B. S., Kleinschek, M. A., Owyang, A. M., Mattson, J. D., Blumenschein, W. M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,532 · see citing works
Manel, N., Unutmaz, D., & Littman, D. R. (2008) · Nature Immunology · doi:10.1038/ni.1610 · Cited by 1,285 · see citing works
Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works
Volpe, E., Servant, N., Zollinger, R., Bogiatzi, S. I., Hupé, P., Barillot, E., & Soumelis, V. (2008) · Nature Immunology · doi:10.1038/ni.1613 · Cited by 938 · see citing works
IL-21 and TGF-β are required for differentiation of human TH17 cells
Yang, L., Anderson, D. E., Baecher‐Allan, C., Hastings, W. D., Bettelli, E., Oukka, M., Kuchroo, V. K., & Hafler, D. A. (2008) · Nature · doi:10.1038/nature07021 · Cited by 926 · see citing works
Pober, J. S., Bevilacqua, M. P., Mendrick, D. L., Lapierre, L. A., Fiers, W., & Gimbrone, M. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.5.1680 · Cited by 736 · see citing works
Self-citationHuman interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
Cosmi, L., Palma, R. D., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., Rodolico, G., Querci, V., Abbate, G., Angeli, R., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080397 · Cited by 704 · see citing works
Teunissen, M., Bos, J. D., Koomen, C. W., Malefyt, R. D. W., & Wierenga, E. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00347.x · Cited by 648 · see citing works
van Beelen, A. J., Zelinková, Z., Taanman-Kueter, E. W., Muller, F. J. M., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 516 · see citing works
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
Dong, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1807 · Cited by 487 · see citing works
Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells
de Beaucoudrey, L., Puel, A., Filipe‐Santos, O., Cobat, A., Ghandil, P., Chrabieh, M., Feinberg, J. M., von Bernuth, H., Samarina, A., Jannière, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080321 · Cited by 438 · see citing works
Burlingham, W. J., Love, R. B., Jankowska−Gan, E., Haynes, L. D., Xu, Q., Bobadilla, J. L., Meyer, K. C., Hayney, M. S., Braun, R. K., Greenspan, D. S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28031 · Cited by 398 · see citing works
Interferon-γ elicits arteriosclerosis in the absence of leukocytes
Tellides, G., Tereb, D. A., Kirkiles-Smith, N. C., Kim, R. W., Wilson, J. H., Schechner, J. S., Lorber, M. I., & Pober, J. S. (2000) · Nature · doi:10.1038/35003221 · Cited by 391 · see citing works
Self-citationLibby, P., & Pober, J. S. (2001) · Immunity · doi:10.1016/s1074-7613(01)00119-4 · Cited by 374 · see citing works
Self-citationMessi, M., Giacchetto, I., Nagata, K., Lanzavecchia, A., Natoli, G., & Sallusto, F. (2002) · Nature Immunology · doi:10.1038/ni872 · Cited by 347 · see citing works
́stergaard, M., Hansen, M. S., Stoltenberg, M., Gideon, P., Klarlund, M., Jensen, K. E., & Lorenzen, I. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 323 · see citing works
Stebbings, R., Findlay, L., Edwards, C., Eastwood, D., Bird, C., North, D., Mistry, Y., Dilger, P., Liefooghe, E., Cludts, I., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3325 · Cited by 317 · see citing works
Antonysamy, M. A., Fanslow, W. C., Fu, F., Li, W., Qian, S., Troutt, A. B., & Thomson, A. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.577 · Cited by 293 · see citing works
PATHOLOGIC FEATURES OF ACUTE RENAL ALLOGRAFT REJECTION ASSOCIATED WITH DONOR-SPECIFIC ANTIBODY
Trpkov, K., Campbell, P. M., Pazderka, F., Cockfield, S. M., Solez, K., & Halloran, P. F. (1996) · Transplantation · doi:10.1097/00007890-199606150-00007 · Cited by 288 · see citing works
Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor
Fanslow, W. C., Sims, J. E., Sassenfeld, H. M., Morrissey, P., Gillis, S. A., Dower, S., & Widmer, M. B. (1990) · Science · doi:10.1126/science.2139736 · Cited by 230 · see citing works
Halloran, P. F., Homik, J., Goes, N. B., Lui, S., Urmson, J. R., Ramassar, V., & Cockfield, S. M. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(96)00015-2 · Cited by 220 · see citing works
Suzuki, K., Murtuza, B., Smolenski, R. T., Sammut, I. A., Suzuki, N., Kaneda, Y., & Yacoub, M. H. (2001) · Circulation · doi:10.1161/hc37t1.094871 · Cited by 202 · see citing works
T L ymphocyte –E ndothelial C ell I nteractions
Choi, J., Enis, D. R., Koh, K. P., Shiao, S. L., & Pober, J. S. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104639 · Cited by 194 · see citing works
Self-citationMembrane interleukin 1 induction on human endothelial cells and dermal fibroblasts.
Kurt‐Jones, E. A., Fiers, W. C., & Pober, J. S. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.7.2317 · Cited by 168 · see citing works
Self-citationValantine, H. A. (2003) · Transplantation · doi:10.1097/01.tp.0000080981.90718.eb · Cited by 164 · see citing works
Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.
Epperson, D. E., & Pober, J. S. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.12.5402 · Cited by 157 · see citing works
Self-citationRole of IL-1 in renal ischemic reperfusion injury.
Haq, M., Norman, J., Saba, S. R., Ramírez, G., & Rabb, H. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v94614 · Cited by 151 · see citing works
Shibuya, K., Robinson, D. S., Zonin, F., Hartley, S. B., Macatonia, S. E., Somoza, C., Hunter, C. A., MURPHY, K. M. M., & O’Garra, A. (1998) · PubMed · Cited by 148 · see citing works
Shibuya, K., Robinson, D. S., Zonin, F., Hartley, S. B., Macatonia, S. E., Somoza, C., Hunter, C. A., MURPHY, K. M. M., & O’Garra, A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1708 · Cited by 145 · see citing works
Shito, M., Wakabayashi, G., Ueda, M., Shimazu, M., Shirasugi, N., Endo, M., Mukai, M., & Kitajima, M. (1997) · Transplantation · doi:10.1097/00007890-199701150-00026 · Cited by 143 · see citing works
Are primary alloresponses truly primary?
Lombardi, G., Sidhu, S., Daly, M. C., Batchelor, J. R., Makgoba, W., & Lechler, R. I. (1990) · International Immunology · doi:10.1093/intimm/2.1.9 · Cited by 130 · see citing works
Murray, A. G., Petzelbauer, P., Hughes, C. C. W., Costa, J. C., Askenase, P. W., & Pober, J. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9146 · Cited by 121 · see citing works
Self-citationInterferon-γ Axis in Graft Arteriosclerosis
Tellides, G., & Pober, J. S. (2007) · Circulation Research · doi:10.1161/01.res.0000258861.72279.29 · Cited by 118 · see citing works
Self-citationThe prognostic significance of specific arterial lesions in acute renal allograft rejection.
Nickeleit, V., Vamvakas, E. C., Pascual, M. A., Poletti, B., & Colvin, R. B. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v971301 · Cited by 118 · see citing works
Regulation of IL-17 production in human lymphocytes
Chen, Z., & O’Shea, J. J. (2007) · Cytokine · doi:10.1016/j.cyto.2007.09.009 · Cited by 106 · see citing works
Shiao, S., Kirkiles-Smith, N., Shepherd, B., McNiff, J., Carr, E. J., & Pober, J. (2007) · Journal of Immunology · doi:10.4049/jimmunol.179.7.4397 · Cited by 98 · see citing works
Self-citationIL-1α and IL-1β Are Endogenous Mediators Linking Cell Injury to the Adaptive Alloimmune Response
Rao, D. A., Tracey, K. J., & Pober, J. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6536 · Cited by 91 · see citing works
Self-citationFunctional Plasticity in Memory T Helper Cell Responses
Krawczyk, C. M., Shen, H., & Pearce, E. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4080 · Cited by 76 · see citing works
Murray, A. G., Libby, P., & Pober, J. S. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.1.151 · Cited by 75 · see citing works
Self-citationWang, Y., Burns, W. R., Tang, P. C. Y., Yi, T., Schechner, J. S., Zerwes, H., Sessa, W. C., Lorber, M. I., Pober, J. S., & Tellides, G. (2004) · The FASEB Journal · doi:10.1096/fj.03-0840fje · Cited by 75 · see citing works
Self-citationThe Challenge of Inhibiting Alloreactive T-Cell Memory
Valujskikh, A. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.01215.x · Cited by 68 · see citing works
Pober, J. S., Bothwell, A. L. M., Lorber, M. I., McNiff, J. M., Schechner, J. S., & Tellides, G. (2003) · Springer Seminars in Immunopathology · doi:10.1007/s00281-003-0135-1 · Cited by 56 · see citing works
Self-citationManes, T. D., Shiao, S. L., Dengler, T. J., & Pober, J. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3237 · Cited by 36 · see citing works
Self-citationShiraishi, M., CSETE, M. E., Yasunaga, C., McDiarmid, S. V., Vannice, J. L., Busuttil, R. W., & Shaked, A. A. (1995) · Journal of Surgical Research · doi:10.1006/jsre.1995.1073 · Cited by 24 · see citing works
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- [5]Choi, J., D.R. Enis, K.P. Koh, S.L. Shiao, and J.S. Pober. 2004. T lymphocyte-endothelial cell interactions. Annu. Rev. Immunol. 22: 683–709. 15032593
- [20]Chabaud, M., J.M. Durand, N. Buchs, F. Fossiez, G. Page, L. Frappart, and P. Miossec. 1999. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42: 963–970. 10323452
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Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works
Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice
Smith, E. E., Prasad, K.-M. R., Butcher, M. J., Dobrian, A. D., Kolls, J. K., Ley, K. F., & Galkina, E. (2010) · Circulation · doi:10.1161/circulationaha.109.924886 · Cited by 422 · see citing works
Eid, R. E., Rao, D. A., Zhou, J., Lo, S.-F. L., Ranjbaran, H., Gallo, A. E., Sokol, S. I., Pfau, S. E., Pober, J. S., & Tellides, G. (2009) · Circulation · doi:10.1161/circulationaha.108.827618 · Cited by 413 · see citing works
Self-citationInhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice
Erbel, C., Chen, L., Bea, F., Wangler, S., Celik, S., Lasitschka, F., Wang, Y., Böckler, D., Katus, H. A., & Dengler, T. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901126 · Cited by 359 · see citing works
Chen, P.-Y., Qin, L., Barnes, C., Charisse, K., Yi, T., Zhang, X., Ali, R., Medina, P. P., Yu, J., Slack, F. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.021 · Cited by 291 · see citing works
Self-citationComplement Membrane Attack Complex
Xie, C. B., Jane‐wit, D., & Pober, J. S. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.02.006 · Cited by 223 · see citing works
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Zheng, Y., Humphry, M., Maguire, J. J., Bennett, M. R., & Clarke, M. C. H. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.008 · Cited by 205 · see citing works
Butcher, M. J., Gjurich, B. N., Phillips, T., & Galkina, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.261784 · Cited by 165 · see citing works
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Gerber, P. A., Buhren, B. A., Steinhoff, M. S., & Homey, B. (2011) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2011.9 · Cited by 163 · see citing works
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Self-citationObermajer, N., Popp, F., Soeder, Y., Haarer, J., Geissler, E. K., Schlitt, H. J., & Dahlke, M. H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401776 · Cited by 137 · see citing works
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Mori, D. N., Kreisel, D., Fullerton, J. N., Gilroy, D. W., & Goldstein, D. R. (2014) · Immunological Reviews · doi:10.1111/imr.12146 · Cited by 137 · see citing works
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Abrahimi, P., Qin, L., Chang, W., Bothwell, A. L. M., Tellides, G., Saltzman, W. M., & Pober, J. S. (2016) · JCI Insight · doi:10.1172/jci.insight.85293 · Cited by 76 · see citing works
Self-citationChadha, R., Heidt, S., Jones, N. D., & Wood, K. J. (2011) · Transplantation · doi:10.1097/tp.0b013e3182126eeb · Cited by 75 · see citing works
Fogal, B., Yi, T., Wang, C., Rao, D. A., Lebastchi, A. H., Kulkarni, S., Tellides, G., & Pober, J. S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003774 · Cited by 68 · see citing works
Self-citationCritical Role of Regulatory T Cells in Th17-Mediated Minor Antigen-Disparate Rejection
Vokaer, B., Rompaey, N. V., Lemaitre, P. H., Lhomme, F., Kubjak, C., Benghiat, F. S., Iwakura, Y., Pétein, M., Field, K. A., Goldman, M., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903961 · Cited by 66 · see citing works
Qiu, C., Wang, Y., Zhao, H., Qin, L., Shi, Y., Zhu, X., Song, L., Zhou, X., Chen, J., Zhou, H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15426 · Cited by 65 · see citing works
Self-citationThébault, P., Lhermite, N., Tilly, G., Texier, L. L., Quillard, T., Heslan, M., Anegón, I., Soulillou, J., Brouard, S., Charreau, B. L., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803767 · Cited by 64 · see citing works
Interleukin 17 in vascular inflammation
von Vietinghoff, S., & Ley, K. F. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.003 · Cited by 64 · see citing works
Sparna, T., Rétey, J., Schmich, K., Albrecht, U., Naumann, K., Gretz, N., Fischer, H., Bode, J. G., & Merfort, I. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-226 · Cited by 64 · see citing works
Calvayrac, O., Rodríguez‐Calvo, R., Alonso, J., Orbe, J., Martı́n-Ventura, J. L., Guadall, A., Gentile, M., Juan‐Babot, O., Egido, J., Beloqui, Ó., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.235721 · Cited by 64 · see citing works
Kim, B., Jin, Y.-H., Meng, L., Hou, W., Kang, H. S., Park, H. S., & Koh, C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-217 · Cited by 59 · see citing works
The Immunopathology of Giant Cell Arteritis Across Disease Spectra
Robinette, M. L., Rao, D. A., & Monach, P. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623716 · Cited by 53 · see citing works
Self-citationPabois, A., Pagie, S., Gérard, N., LABOISSE, C. L., Pattier, S., Hulin, P., Nédellec, S., Toquet, C. S., & Charreau, B. L. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.01.016 · Cited by 53 · see citing works
Immunological and Fibrotic Mechanisms in Cardiac Allograft Vasculopathy
Jansen, M. A. A., Otten, H. G., de Weger, R. A., & Huibers, M. M. H. (2015) · Transplantation · doi:10.1097/tp.0000000000000848 · Cited by 53 · see citing works
Vascular Signaling in Allogenic Solid Organ Transplantation – The Role of Endothelial Cells
Kummer, L., Zaradzki, M., Vijayan, V., Arif, R., Weigand, M. A., Immenschuh, S., Wagner, A. H., & Larmann, J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00443 · Cited by 48 · see citing works
Bharadwaj, A. S., Schewitz‐Bowers, L. P., Wei, L., Lee, R., & Smith, J. R. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12058 · Cited by 44 · see citing works
Sterile inflammation in thoracic transplantation
Frye, C. C., Bery, A. I., Kreisel, D., & Kulkarni, H. S. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03615-7 · Cited by 39 · see citing works
Innate Immunity and Resistance to Tolerogenesis in Allotransplantation
Bénichou, G., Tonsho, M., Tocco, G., Nadazdin, O., & Madsen, J. C. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00073 · Cited by 36 · see citing works
Immune-Mediated Vascular Injury and Dysfunction in Transplant Arteriosclerosis
von Rossum, A., Laher, I., & Choy, J. C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00684 · Cited by 36 · see citing works
Toldo, S. A., Quader, M. A., Salloum, F. N., Mezzaroma, E., & Abbate, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060958 · Cited by 37 · see citing works
Liu, A. C., Lee, M. W., McManus, B. M., & Choy, J. C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102527 · Cited by 35 · see citing works
Ahmad, U., Ali, R., Lebastchi, A. H., Qin, L., Lo, S.-F. L., Yakimov, A. O., Khan, S. F., Choy, J. C., Geirsson, A., Pober, J. S., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902283 · Cited by 36 · see citing works
Self-citationTh17 Cells and Transplant Acceptance
Burrell, B. E., & Bishop, D. K. (2010) · Transplantation · doi:10.1097/tp.0b013e3181f5c3de · Cited by 35 · see citing works
Human allograft rejection in humanized mice: a historical perspective
Brehm, M. A., & Shultz, L. D. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2011.64 · Cited by 30 · see citing works
Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease
Lukens, J. R., & Kanneganti, T. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0434-8 · Cited by 30 · see citing works
Tian, Q., Zhang, Z., Tan, L., Yang, F., Xu, Y., Guo, Y., Wei, D., Wu, C., Cao, P., Ji, J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk0270 · Cited by 29 · see citing works
Digoxin Attenuates Acute Cardiac Allograft Rejection by Antagonizing RORγt Activity
Wu, J., Zhou, C., Chen, W., Xie, A., Li, J., Wang, S., Ye, P., Wang, W., & Xia, J. (2013) · Transplantation · doi:10.1097/tp.0b013e31827a48f5 · Cited by 27 · see citing works
Jones, I. K. A., Orloff, S. L., Burg, J. M., Haese, N. N., Andoh, T. F., Chambers, A. Q., Fei, S. S., Gao, L., Kreklywich, C. N., Streblow, Z. J., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16149 · Cited by 26 · see citing works
Kish, D. D., Gorbachev, A. V., & Fairchild, R. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100928 · Cited by 24 · see citing works
Wei, C., Ma, L., Chi, H., Lin, L., Zhang, S., Yin, W., Liu, T., Gao, H., & Shi, W. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16071 · Cited by 23 · see citing works
Burzynski, L. C., Humphry, M., Bennett, M. R., & Clarke, M. C. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.667915 · Cited by 23 · see citing works
Majumder, P., Zhang, Y., Iglesias, M., Fan, L., Kelley, J. A., Andrews, C., Patel, N. L., Stagno, J. R., Oh, B. C., Furtmüller, G. J., et al. (2020) · Small · doi:10.1002/smll.202002791 · Cited by 23 · see citing works
B cell–derived IL-1β and IL-6 drive T cell reconstitution following lymphoablation
Hasgur, S., Fan, R., Zwick, D. B., Fairchild, R. L., & Valujskikh, A. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15960 · Cited by 22 · see citing works
Regulation of the CD4+ T cell allo-immune response by endothelial cells
Taflin, C., Charron, D. J., Glotz, D., & Mooney, N. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.07.009 · Cited by 21 · see citing works
Is hypertension an autoimmune disease?
Pober, J. S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77766 · Cited by 18 · see citing works
Self-citationAssociation of Pericardiac Adipose Tissue With Coronary Artery Disease
Li, M., Qi, L., Li, Y., Zhang, S., Lin, L., Zhou, L., Han, W., Qu, X., Cai, J., Ye, M., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724859 · Cited by 18 · see citing works
Zhou, J., Qin, L., Yi, T., Ali, R., Li, Q., Jiao, Y., Li, G., Tobiásová, Z., Huang, Y., Zhang, J., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.306932 · Cited by 18 · see citing works
Self-citationExpression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis
Zhang, H., Xia, B., Li, J., Zhao, Q., Chen, Z., Zhou, R., & Wu, J. (2016) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-016-1538-2 · Cited by 15 · see citing works
Aral, A. M., Zamora, R., Barclay, D. A., Yin, J., El-Dehaibi, F., Erbas, V. E., Dong, L., Zhang, Z., Sahin, H., Gorantla, V. S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.591154 · Cited by 14 · see citing works
Zhang, Y., Liu, K., Guo, M., Yang, Y., & Zhang, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112400 · Cited by 13 · see citing works
Burzynski, L. C., Morales-Maldonado, A., Rodgers, A., Kitt, L., Humphry, M., Figg, N. L., Bennett, M. R., & Clarke, M. C. H. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad091 · Cited by 12 · see citing works
Experimental models of cardiac transplantation
Baldwin, W. M., Su, C. A., Shroka, T. M., & Fairchild, R. L. (2014) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000113 · Cited by 12 · see citing works
Yazdani, M., Khosropanah, S., & Doroudchi, M. (2019) · Archives of Medical Science - Atherosclerotic Diseases · doi:10.5114/amsad.2019.87525 · Cited by 11 · see citing works
Zhao, J., Que, W., Du, X., Fujino, M., Ichimaru, N., Ueta, H., Tokuda, N., Guo, W.-Z., Zabrocki, P., de Haard, H., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.555996 · Cited by 10 · see citing works
Yao, Z., Li, M., & Lv, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1058296 · Cited by 9 · see citing works
Wedel, J., Nakayama, H., Kochupurakkal, N. M., Koch, J., Klagsbrun, M., Bielenberg, D. R., & Briscoe, D. M. (2016) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000373 · Cited by 9 · see citing works
Xu, M., Garcia-Aroz, S., Banan, B., Wang, X., Rabe, B. J., Zhou, F., Nayak, D. K., Zhang, Z., Jia, J., Upadhya, G. A., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.15098 · Cited by 9 · see citing works
Khalifian, S., Raimondi, G., Lee, W. A., & Brandacher, G. (2014) · Immunotherapy · doi:10.2217/imt.14.25 · Cited by 8 · see citing works
Interleukin-17 and Atherosclerotic Vascular Disease
Pober, J. S. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.228338 · Cited by 8 · see citing works
Self-citationIida, S., Tsuda, H., Tanaka, T., Kish, D. D., Abe, T., Su, C. A., Abe, R., Tanabe, K., Valujskikh, A., Baldwin, W. M., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1500876 · Cited by 7 · see citing works
Guo, Z., Chen, T., Wen, X., Fu, Q., Lai, J., Li, J., Chen, J., Zheng, L., Wang, W. J., Cao, Q., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102332 · Cited by 6 · see citing works
The role of γδ T17 cells in cardiovascular disease
Ling, S., You, Z., Li, Y., Zhang, J., Zhao, S., He, Y., & Chen, X. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0822-761rr · Cited by 5 · see citing works
Chou, F., Huang, S., & Sytwu, H. (2012) · International Journal of Endocrinology · doi:10.1155/2012/296485 · Cited by 5 · see citing works
Effects of immunosuppressive agents on T h17 cells involved in transplantation
Wang, X., van Velkinburgh, J. C., Zhang, Y., Ni, B., & Yang, Z. (2012) · Clinical Transplantation · doi:10.1111/ctr.12043 · Cited by 2 · see citing works
Choy, J. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99563-2 · Cited by 2 · see citing works
IL-17 level in patients with acute myocardial infarction and its effect on lipid profile
Ibrahim, A. E., Hasan, H. A., & Jawad, A. H. (2014) · European Journal of Chemistry · doi:10.5155/eurjchem.5.1.186-188.938
OBSOLETE: Transplant Arteriosclerosis
Choy, J. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99563-1
Choy, J. C., & Stojcic, M. P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00037-6
Karsalari, P. D., Asnaashari, K., & Rezaei, N. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2500425
TRPM4 modulates endothelial inflammation and pyroptosis via the HSP60-NF-κB axis
Shen, M., Zhao, Y., Zhang, Y., Tong, T., Cui, Y., Guo, X., Liang, W., Ma, Z., Jin, J., Xiong, L., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1823348
Niu, J., Deng, Z., Jin, S., Li, L., Chen, Z., Ying, Y., Pan, G., Yang, H., Li, C., Feng, T., et al. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116150
- Authors
- Rao, D. A., Eid, R. E., Qin, L., Yi, T., Kirkiles-Smith, N. C., Tellides, G., & Pober, J. S.
- Affiliations
- 1Department of Immunobiology
- 2Department of Surgery
- Yale University (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-12-15
- Volume
- 205
- Issue
- 13
- Pages
- 3145-3158
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2605225
- OpenAlex
- W2152079015
- Cited by
- 86
- References
- 60
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 11
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL070295, HL070295)
- National Institute of General Medical Sciences (5T32 GM 07205, T32GM007205)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- interleukin-1, IL-17, allograft rejection, T cell infiltration, intimal inflammation, endothelial cells, CCR6, vascular smooth muscle cells, interleukin-6, interleukin-8, CCL20, alloreactivity, skin grafts, transplantation immunology
- MeSH terms
- Animals, Arteries, Cells, Cultured, Graft Rejection, Humans, Inflammation, Lymphocyte Activation, Transplantation, Homologous, CD4-Positive T-Lymphocytes, Skin Transplantation, Cytokines, Mice, SCID, Tunica Intima, Chemokines, Interleukin-17, Oligonucleotide Array Sequence Analysis, Endothelial Cells, Mice, Interleukin-1alpha, Receptors, CCR6
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