How regulatory T cells sense and adapt to inflammation

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P. M., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012) · Nature · doi:10.1038/nature10772 · Cited by 823 · see citing works

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Gagliani, N., Vesely, M. C. A., Iseppon, A., Brockmann, L., Xu, H. Y., Palm, N. W., de Zoete, M. R., Licona-Limón, P., Paiva, R., Ching, T. H., et al. (2015) · Nature · doi:10.1038/nature14452 · Cited by 797 · see citing works

Stability of the Regulatory T Cell Lineage in Vivo

Rubtsov, Y. P., Niec, R. E., Josefowicz, S., Li, L., Darce, J., Mathis, D., Benoist, C., & Rudensky, A. Y. (2010) · Science · doi:10.1126/science.1191996 · Cited by 730 · see citing works

The plasticity and stability of regulatory T cells

Sakaguchi, S., Vignali, D. A. A., Rudensky, A. Y., Niec, R. E., & Waldmann, H. (2013) · Nature reviews. Immunology · doi:10.1038/nri3464 · Cited by 529 · see citing works

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

Zheng, S. G., Gray, J. D., Ohtsuka, K., Yamagiwa, S., & Horwitz, D. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4183 · Cited by 465 · see citing works

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

Feng, Y., Arvey, A., Chinen, T., van der Veeken, J., Gasteiger, G., & Rudensky, A. Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.031 · Cited by 422 · see citing works

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

Li, B., Samanta, A., Song, X., Iacono, K. T., Bembas, K., Tao, R. N., Basu, S., Riley, J. L., Hancock, W. W., Shen, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700298104 · Cited by 410 · see citing works

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

van Loosdregt, J., Fleskens, V., Fu, J., Brenkman, A., Bekker, C., Pals, C., Meerding, J., Berkers, C., Barbi, J., Gröne, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.018 · Cited by 325 · see citing works

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

Chen, Z., Barbi, J. J., Bu, S., Yang, H., Li, Z., Gao, Y., Jinasena, D., Fu, J. L., Lin, F., Chen, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.006 · Cited by 305 · see citing works

FOXP3+ regulatory T cells and their functional regulation

Li, Z., Li, D., Tsun, A., & Li, B. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.10 · Cited by 290 · see citing works

Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance

Zeng, H., Zhang, R., Jin, B., & Chen, L. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.44 · Cited by 211 · see citing works

The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

Liu, Z.-M., Wang, K.-P., Ma, J., & Zheng, S. G. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.133 · Cited by 120 · see citing works

Tissue resident regulatory T cells: novel therapeutic targets for human disease

Zhou, X., Tang, J., Cao, H., Fan, H., & Li, B. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.23 · Cited by 63 · see citing works

Regulatory T cells turn pathogenic

Guo, J., & Zhou, X. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.12 · Cited by 61 · see citing works

The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases

Park, B. V., & Pan, F. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.21 · Cited by 50 · see citing works

A Degrading View of Regulatory T Cells

Laurence, A. D. J., Belkaid, Y., & O’Shea, J. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.017 · Cited by 14 · see citing works

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

Kumar, V. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.002 · Cited by 649 · see citing works

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

Colamatteo, A., Carbone, F., Bruzzaniti, S., Galgani, M., Fusco, C., Maniscalco, G. T., Rella, F. D., de Candia, P., & Rosa, V. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03136 · Cited by 139 · see citing works

Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling

Nguyen, T. V., Piao, C. H., Fan, Y. J., Shin, D., Kim, S. Y., Song, H.-J., Song, C. H., Shin, H. S., & Chai, O. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-69234-1 · Cited by 67 · see citing works

TIGIT as a Promising Therapeutic Target in Autoimmune Diseases

Yue, C., Gao, S., Li, S., Xing, Z., Qian, H., Hu, Y., Wang, W., & Hua, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911919 · Cited by 53 · see citing works

A unified model of the biology of peripartum depression

Levin, G., & Ein‐Dor, T. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02439-w · Cited by 48 · see citing works

Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells

Chen, Y., Colello, J., Jarjour, W. N., & Zheng, S. G. (2019) · Cells · doi:10.3390/cells8020188 · Cited by 44 · see citing works

Helios But Not CD226, TIGIT and Foxp3 is a Potential Marker for CD4 Treg Cells in Patients with Rheumatoid Arthritis

Yang, M., Liu, Y., Mo, B., Xue, Y., Ye, C., Jiang, Y., Bi, X., Liu, M., Wu, Y., Wang, J., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.2139/ssrn.3228224 · Cited by 43 · see citing works

Bridging Neurobiological Insights and Clinical Biomarkers in Postpartum Depression: A Narrative Review

Zhang, K., He, L., Li, Z. B., Ding, R., Han, X., Chen, B., Cao, G., Ye, J.-H., Li, T., & Fu, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168835 · Cited by 33 · see citing works

Ccl2-Induced Regulatory T Cells Balance Inflammation Through Macrophage Polarization During Liver Reconstitution

Wang, R., Liang, Q., Zhang, Q., Zhao, S., Lin, Y., Liu, B., Ma, Y., Mai, X., Fu, Q., Bao, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202403849 · Cited by 25 · see citing works

Lamin A/C deficiency in CD4 + T‐cells enhances regulatory T‐cells and prevents inflammatory bowel disease

Toribio‐Fernández, R., Herrero‐Fernández, B., Zorita, V., López, J. A., Vázquez, J., Criado, G., Pablos, J. L., Collas, P., Sánchez‐Madrid, F., Andrés, V., et al. (2019) · The Journal of Pathology · doi:10.1002/path.5332 · Cited by 21 · see citing works

Regulatory T cells as therapeutic targets and mediators

Sharma, A., & Rudra, D. (2019) · International Reviews of Immunology · doi:10.1080/08830185.2019.1621310 · Cited by 16 · see citing works

Therapeutic potential of exosomes in periodontal regeneration: Immunomodulatory and tissue-repair mechanisms

Yang, S., Han, C., Wang, Q., Ai, Y., Wang, D., & Song, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1675707 · Cited by 15 · see citing works

Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception

Moldenhauer, L. M., Jin, M., Wilson, J. J., Green, E. S., Sharkey, D. J., Salkeld, M. D., Bristow, T. C., Hull, M. L., Dekker, G., & Robertson, S. A. (2022) · Endocrinology · doi:10.1210/endocr/bqac098 · Cited by 14 · see citing works

Using Volatile Organic Compounds to Investigate the Effect of Oral Iron Supplementation on the Human Intestinal Metabolome

Ahmed, A., Slater, R., Lewis, S. J., & Probert, C. S. (2020) · Molecules · doi:10.3390/molecules25215113 · Cited by 10 · see citing works

Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA

Wu, L.-X., Xie, J.-H., Li, J., Li, W., Mao, X.-T., Huang, L.-J., Chen, H., Zhong, J.-Y., Lin, L., Su, S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01344-0 · Cited by 7 · see citing works

The Relationship Between FoxP3 and SOCs3 Gene Expressions and Disease Activity in Rheumatoid Arthritis

Anani, H. A. A., Tawfeik, A. M., El-Dydamoni, O. A., Maghraby, H. M., Ebrahem, E. E., Seliem, N., elhassan, H. A. A., & Kassem, E. A. (2022) · Current Rheumatology Reviews · doi:10.2174/1573397118666220401145710 · Cited by 6 · see citing works

Hydroxysafflor yellow A attenuates allergic response of ovalbumin induced allergic rhinitis via Nrf2/ HO ‐1 and inflammatory signaling pathways

Ma, Q., Li, G., He, J., Wang, J., & Ben, Y. (2023) · Environmental Toxicology · doi:10.1002/tox.23783 · Cited by 6 · see citing works

Update on Mesenchymal and Induced Pluripotent Stem Cells

Al‐Anazi, K. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77857 · Cited by 5 · see citing works

GMSC: Updates of Advances on Its Therapy in Immunological Diseases

Hou, Y., & Zheng, S. G. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85153 · Cited by 2 · see citing works

Low interferon-gamma release in response to phytohemagglutinin predicts the high severity of diseases

He, X., Liu, L., Ji, X., Xian, Y.-B., Yan, Y.-J., Xu, H., Li, S., Chun-li, P., Zhou, J., Yuan, C., et al. (2019) · Medicine · doi:10.1097/md.0000000000015843 · Cited by 2 · see citing works

Biological and pathological role of A-type lamins in T-cell mediated immune response

Toribio‐Fernández, R. (2019) · doi:10.4321/repisalud.7236

Recent Advances in Volatile Organic Compound Analysis as Diagnostic Biomarkers

Drabińska, N., & Lacy Costello, B. D. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-5349-8

Control of inflammation by integration of environmental cues by regulatory T cells

Chaudhry, A., & Rudensky, A. Y. (2013) · Journal of Clinical Investigation · doi:10.1172/jci57175 · Cited by 183 · see citing works

Mechanisms of TREG cell adaptation to inflammation

Alvarez, F., Al-Aubodah, T.-A., Yang, Y. H., & Piccirillo, C. A. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1mr0120-196r · Cited by 40 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

Yamaguchi, T., Wing, J. B., & Sakaguchi, S. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.10.002 · Cited by 236 · see citing works

Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity

Hu, W., Wang, Z.-M., Feng, Y., Schizas, M., Hoyos, B. E., van der Veeken, J., Verter, J. G., Bou-Puerto, R., & Rudensky, A. Y. (2021) · Nature Immunology · doi:10.1038/s41590-021-01001-4 · Cited by 92 · see citing works