Cited by 184T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

Control of inflammation by integration of environmental cues by regulatory T cells

Open access
Chaudhry, Ashutosh, Rudensky, Alexander Y.·2013·Journal of Clinical Investigation

Abstract

Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.

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Crossref · 10.1172/jci57175

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  • STAT3 and Foxp3 coregulate IL-10 in Tregs through histone acetyl transferase-1/FoxP3-mediated epigenetic modification of the IL-10 promoter, maintaining the ability of Foxp3+ Tregs to inhibit inflammatory Th17 cells.

    “STAT3 and Foxp3 appear to coregulate IL10 in T-regs”

    From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Chaudhry and Rudensky, 2013

    In “Treg-mediated control of inflammatory responses” (page unavailable), the paper says STAT3 binds Foxp3 and modulates gene expression, and that STAT3 is needed to control Th17 responses. It does not identify IL-10 as a gene they coregulate. The “Overriding inhibitions” section instead describes IL-10-mediated STAT3 activation in Tregs; neither passage supports the claimed acetyltransferase-mediated modification of the IL-10 promoter. (LLM, conf=0.87)

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Research works printed but not linked: 2

  1. Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol. 2011;29:621-663.
  2. Chaudhry A, et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science. 2009;326(5955):986-991.

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Authors
Chaudhry, A., & Rudensky, A. Y.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Venue
Journal of Clinical Investigation
Published
2013-03-01
Volume
123
Issue
3
Pages
939-944
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2053418050
Cited by
183
References
56
Citations by year
2026: 3 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 18 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 23 · 2014: 17 · 2013: 10
FWCI
2.09
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • Cancer Research Institute
  • Memorial Sloan-Kettering Cancer Center
  • National Institutes of Health (10021)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
regulatory T cells, inflammation control, environmental cues, Treg homeostasis, Treg migration, immunosuppression, commensal microorganisms, self-tolerance
MeSH terms
Animals, Cell Differentiation, Gene Expression Regulation, Humans, Inflammation, Cytokines, Inflammation Mediators, T-Lymphocytes, Regulatory, STAT Transcription Factors

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