Oct4 links multiple epigenetic pathways to the pluripotency network
Open accessAbstract
Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulatory activities. Here we employed an improved affinity purification approach combined with mass spectrometry to purify Oct4 protein complexes in mouse embryonic stem cells (mESCs), and discovered many novel Oct4 partners important for self-renewal and pluripotency of mESCs. Notably, we found that Oct4 is associated with multiple chromatin-modifying complexes with documented as well as newly proved functional significance in stem cell maintenance and somatic cell reprogramming. Our study establishes a solid biochemical basis for genetic and epigenetic regulation of stem cell pluripotency and provides a framework for exploring alternative factor-based reprogramming strategies.
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Many pioneer factors recruit chromatin remodelers.
“The mechanisms of pioneer factor action are still being established [37], but at least some of them (such as FOXA, OCT4 and SOX2/SOX11) have been shown to initiate chromatin opening by direct displacement of histones [38–41], whilst many others recruit chromatin remodelers [42–50].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [42]
The Results and Discussion section (page not available) reports that Oct4 physically interacts with components of several chromatin-remodeling and other epigenetic complexes. It does not establish that many pioneer factors recruit remodelers, or that Oct4’s interactions constitute recruitment to open chromatin. (LLM, conf=0.84)
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- Authors
- Ding, J., Xu, H., Faiola, F., Ma'ayan, A., & Wang, J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Wang, Jianlong
- Venue
- Cell Research
- Published
- 2011-11-15
- Volume
- 22
- Issue
- 1
- Pages
- 155-167
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3252465
- OpenAlex
- W2043823697
- Cited by
- 162
- References
- 54
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 12 · 2020: 15 · 2019: 16 · 2018: 10 · 2017: 9 · 2016: 16 · 2015: 14 · 2014: 15 · 2013: 17 · 2012: 13
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- New York State Department of Health (N09G315)
- New York State Stem Cell Science
- National Institutes of Health
- National Institute of General Medical Sciences (1R01-GM095942-01A1, P50GM071558, R01GM095942)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK088541)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Oct4, pluripotency, stem cell self-renewal, protein complexes, chromatin-modifying complexes, epigenetic regulation, somatic cell reprogramming, mouse embryonic stem cells, protein-protein interaction, transcription factors
- MeSH terms
- Animals, Cell Nucleus, Chromatography, Affinity, Electrophoresis, Polyacrylamide Gel, Mass Spectrometry, Protein Interaction Mapping, Pluripotent Stem Cells, Epigenesis, Genetic, Multiprotein Complexes, Octamer Transcription Factor-3, Mice, Embryonic Stem Cells, SOXB1 Transcription Factors, Cellular Reprogramming
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