The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Generation of neural progenitor cells by chemical cocktails and hypoxia
Open accessAbstract
Neural progenitor cells (NPCs) can be induced from somatic cells by defined factors. Here we report that NPCs can be generated from mouse embryonic fibroblasts by a chemical cocktail, namely VCR (V, VPA, an inhibitor of HDACs; C, CHIR99021, an inhibitor of GSK-3 kinases and R, Repsox, an inhibitor of TGF-β pathways), under a physiological hypoxic condition. These chemical-induced NPCs (ciNPCs) resemble mouse brain-derived NPCs regarding their proliferative and self-renewing abilities, gene expression profiles, and multipotency for different neuroectodermal lineages in vitro and in vivo. Further experiments reveal that alternative cocktails with inhibitors of histone deacetylation, glycogen synthase kinase, and TGF-β pathways show similar efficacies for ciNPC induction. Moreover, ciNPCs can also be induced from mouse tail-tip fibroblasts and human urinary cells with the same chemical cocktail VCR. Thus our study demonstrates that lineage-specific conversion of somatic cells to NPCs could be achieved by chemical cocktails without introducing exogenous factors.
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1 retracted
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Cited by
Hu, W., Qiu, B., Guan, W., Wang, Q., Wang, M., Li, W., Gao, L., Shen, L., Huang, Y., Xie, G., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.006 · Cited by 484
Self-citationDirect reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.
Fu, Y., Huang, C., Xu, X., Gu, H., Ye, Y., Jiang, C., Qiu, Z., & Xie, X. (2015) · Cell Research · doi:10.1038/cr.2015.99 · Cited by 248
Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives
Wang, J., Sun, S., & Deng, H. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.08.001 · Cited by 91
Chemical compound-based direct reprogramming for future clinical applications.
Takeda, Y., Harada, Y., Yoshikawa, T., & Dai, P. (2018) · Bioscience Reports · doi:10.1042/bsr20171650 · Cited by 57
Tang, Y., & Cheng, L. (2017) · Protein & Cell · doi:10.1007/s13238-017-0373-y · Cited by 22
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Metadata
- Authors
- Cheng, L., Hu, W., Qiu, B., Zhao, J., Yu, Y., Guan, W., Wang, M., Yang, W., & Pei, G.
- Venue
- Cell Research
- Published
- 2014-03-18
- Volume
- 24
- Issue
- 6
- Pages
- 665-679
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2033500695
- Cited by
- 254
- References
- 50
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cheng, L., Hu, W., Qiu, B., Zhao, J., Yu, Y., Guan, W., Wang, M., Yang, W., & Pei, G. (2014). Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Research. https://doi.org/10.1038/cr.2014.32
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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