The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
High salt primes a specific activation state of macrophages, M(Na)
Open accessAbstract
High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation. High salt induced the proinflammatory aspects by activating p38/cFos and/or Erk1/2/cFos pathways, while inhibited the anti-inflammatory and proendocytic aspects by Erk1/2/signal transducer and activator of transcription 6 pathway. Consistent with the in vitro results, high-salt diet increased proinflammatory gene expression of mouse alveolar macrophages. In mouse models of acute lung injury, high-salt diet aggravated lipopolysaccharide-induced pulmonary macrophage activation and inflammation in lungs. These results identify a novel macrophage activation state, M(Na), and high salt as a potential environmental risk factor for lung inflammation through the induction of M(Na).
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Khalili, H., Chan, S. S. M., Lochhead, P., Ananthakrishnan, A. N., Hart, A. R., & Chan, A. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0022-9 · Cited by 283
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension
Barbaro, N. R., Foss, J. D., Kryshtal, D. O., Tsyba, N., Kumaresan, S., Xiao, L., Mernaugh, R. L., Itani, H. A., Loperena, R., Chen, W., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.002 · Cited by 282
Sodium in the microenvironment regulates immune responses and tissue homeostasis
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Vukmanovic-Stejic, M., Chambers, E. S., Suárez-Fariñas, M., Sandhu, D., Fuentes-Duculan, J., Patel, N., Agius, E., Lacy, K. E., Turner, C. T., Larbi, A., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.032 · Cited by 103
Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
Rossitto, G., Mary, S., Chen, J. Y., Boder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17820-2 · Cited by 94
Metadata
- Authors
- Zhang, W.-C., Zheng, X.-J., Du, L.-J., Sun, J.-Y., Shen, Z.-X., Shi, C., Sun, S., Zhang, Z., Chen, X.-Q., Qin, M., Liu, X., Tao, J., Jia, L., Fan, H.-Y., Zhou, B., Yu, Y., Ying, H., Hui, L., Liu, X., Yi, X., Liu, X., Zhang, L., & Duan, S.-Z.
- Venue
- Cell Research
- Published
- 2015-07-24
- Volume
- 25
- Issue
- 8
- Pages
- 893-910
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2119954265
- Cited by
- 242
- References
- 14
- FWCI
- 20.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhang, W.-C., Zheng, X.-J., Du, L.-J., Sun, J.-Y., Shen, Z.-X., Shi, C., Sun, S., Zhang, Z., Chen, X.-Q., Qin, M., Liu, X., Tao, J., Jia, L., Fan, H.-Y., Zhou, B., Yu, Y., Ying, H., Hui, L., Liu, X., . . . Duan, S.-Z. (2015). High salt primes a specific activation state of macrophages, M(Na). Cell Research. https://doi.org/10.1038/cr.2015.87
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