Regulatory T cells in cancer immunotherapy

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187

Regulatory T Cells and Immune Tolerance

Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,475

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

Robert, C., Thomas, L., Bondarenko, I., O'Day, S., Weber, J., Garbe, C., Lebbe, C., Baurain, J.-F., Testori, A., Grob, J.-J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1104621 · Cited by 4,496

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses

Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315

Cancer immunotherapy: moving beyond current vaccines

Rosenberg, S. A., Yang, J. C.-H., & Restifo, N. P. (2004) · Nature Medicine · doi:10.1038/nm1100 · Cited by 2,980

Prognostic Signature and Therapeutic Value Based on Membrane Lipid Biosynthesis-Related Genes in Breast Cancer

Xu, Y., Jin, Y., Gao, S., Wang, Y., Qu, C., Wu, Y., Ding, N., Dai, Y., Jiang, L., & Liu, S. (2022) · Journal of Oncology · doi:10.1155/2022/7204415 · Cited by 14

Metformin enhances the antitumor activity of oncolytic herpes simplex virus HF10 (canerpaturev) in a pancreatic cell cancer subcutaneous model

Abdelmoneim, M., Eissa, I. R., Aboalela, M. A., Naoe, Y., Matsumura, S., Sibal, P. A., Bustos‐Villalobos, I., Tanaka, M., Kodera, Y., & Kasuya, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-25065-w · Cited by 14

Dual roles of IL-22 at ischemia-reperfusion injury and acute rejection stages of rat allograft liver transplantation

Zhang, Y., Wang, X., Mao, L., Yang, D., Gao, W., Tian, Z., Zhang, M., Yang, X., Ma, K., Wu, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23266 · Cited by 13

Donor lymphocyte infusion leads to diversity of specific T cell responses and reduces regulatory T cell frequency in clinical responders

Hofmann, S., Schmitt, M. W., Götz, M., Döhner, H., Wiesneth, M., Bunjes, D. W., & Greiner, J. (2018) · International Journal of Cancer · doi:10.1002/ijc.31753 · Cited by 14

Foxp3 + Regulatory T Cells Associated With CCL17/CCR4 Expression in Carcinomas of Dogs

Maeda, S., Nakazawa, M., Uchida, M., Yoshitake, R., Nakagawa, T., Nishimura, R., Miyamoto, R., Bonkobara, M., Yonezawa, T., & Momoi, Y. (2020) · Veterinary Pathology · doi:10.1177/0300985820921535 · Cited by 14

The effect of CCL5 on the immune cells infiltration and the prognosis of patients with kidney renal clear cell carcinoma

Bai, S., Wu, Y., Yan, Y., Kang, H., Zhang, J., Ma, W., Gao, Y., Hui, B., Li, R., Zhang, X., et al. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.51126 · Cited by 14

Combination of Lenvatinib and Pembrolizumab as Salvage Treatment for Paucicellular Variant of Anaplastic Thyroid Cancer: A Case Report

Luongo, C., Porcelli, T., Sessa, F., Stefano, M. A. D., Scavuzzo, F., Damiano, V., Klain, M., Bellevicine, C., Matano, E., Troncone, G., et al. (2021) · Current Oncology · doi:10.3390/curroncol28060450 · Cited by 14

Comprehensive Immune Monitoring of Clinical Trials to Advance Human ImmunotherapyPreprint

Hartmann, F. J., Babdor, J., Gherardini, P. F., Amir, E.-A. D., Jones, K. B., Sahaf, B., Marquez, D. M., Krutzik, P. O., O'Donnell, E. A., Sigal, N., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/489765 · Cited by 14

Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors

Chen, J., Cui, N., He, S., Xia, C.-Y., & Li, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06346-0 · Cited by 14

Colorectal cancer: the immune microenvironment and the gut microbiota – new perspectives, challenges, and opportunities

Zhou, P., Zhang, W., Liao, Y., Zhai, Z., Lu, S., Jiang, S., Hu, W., & Gong, W. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002573 · Cited by 17

The Role of Intestinal Microbiota and Immune System Interactions in Autoimmune Diseases

Yurtseven, B., Aydemir, E., & Ayaz, F. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s569016 · Cited by 19

Radiotherapy planning parameters correlate with changes in the peripheral immune status of patients undergoing curative radiotherapy for localized prostate cancer

Hoffmann, E., Paulsen, F., Schaedle, P., Zips, D., Gani, C., Rammensee, H., Gouttefangeas, C., & Eckert, F. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-03002-6 · Cited by 14

The Prognostic Value of GNG7 in Colorectal Cancer and Its Relationship With Immune Infiltration

Fang, C., Zhong, R., Qiu, C., & Zou, B. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.833013 · Cited by 13

Modulation of immunosuppressive cells and noncoding RNAs as immunotherapy in osteosarcoma

Xia, Y., Wang, D., Piao, Y., Chen, M., Wang, D., Jiang, Z., & Liu, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1025532 · Cited by 13

Establishment and validation of a novel anoikis-related prognostic signature of clear cell renal cell carcinoma

Liu, Y., Shi, Z., Zheng, J., Zheng, Z., Sun, H., Xuan, Z., Bai, Y., Fu, M., Du, Y., & Shao, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1171883 · Cited by 13

Unlocking Dendritic Cell-Based Vaccine Efficacy through Genetic Modulation—How Soon Is Now?

Elwakeel, A., Bridgewater, H. E., & Bennett, J. (2023) · Genes · doi:10.3390/genes14122118 · Cited by 13

Multi-omic analyses of m5C readers reveal their characteristics and immunotherapeutic proficiency

Xu, R. J., Wang, Y., & Kuang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-52110-7 · Cited by 13

FANCI Inhibition Induces PARP1 Redistribution to Enhance the Efficacy of PARP Inhibitors in Breast Cancer

Huang, Y.-Z., Sang, M., Xi, P.-W., Xu, R.-X., Cai, M., Wang, Z.-W., Zhao, J., Li, Y.-H., Yin, P., Ding, Q., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2738 · Cited by 13

Comprehensive macro and micro views on immune cells in ischemic heart disease

Zhao, Y., Tan, M., Yin, Y., Zhang, J., Song, Y., Li, H., Lin, Y., Jin, Y., Wu, Z., Yang, T., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13725 · Cited by 13

A role of gut microbiota metabolites in HLA-E and NKG2 blockage immunotherapy against tumors: new insights for clinical application

Cheng, W., Zhu, N., Wang, J., & Yang, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331518 · Cited by 14

Discovery, synthesis and biological evaluation of novel isoquinoline derivatives as potent indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase dual inhibitors

Lin, Z., Ning, X.-L., Lai, R., Hai, L., Nie, R., Guo, L., Li, G., Yang, Z., & Wu, Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116852 · Cited by 13

Engineering Modular Peptide Nanoparticles for Ferroptosis‐Enhanced Tumor Immunotherapy

Wu, B., Yang, X., Kong, N., Liang, J., Li, S., & Wang, H. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202421703 · Cited by 13

Association between systemic immune-inflammation index and the risk of all-cause, cancer and non-cancer mortality in the general population: results from national health and nutrition examination survey 2005–2018

Wu, S., Liu, Z., Li, X., Gao, S., Si, Z., Chen, Q., & Xia, P. (2025) · BMC Public Health · doi:10.1186/s12889-025-21423-1 · Cited by 13

Peripheral blood cell counts as predictors of immune-related adverse events in cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis

Zhang, X., Zhang, B., Li, D., Yang, Y., Lin, S., Zhao, R., Li, Y., & Peng, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1528084 · Cited by 18

Novel oncolytic vaccinia virus armed with interleukin-27 is a potential therapeutic agent for the treatment of murine pancreatic cancer

Jia, Y., Wang, Y., Zhao, G., Yang, Y., Yan, W., Wang, R., Han, B., Wang, L., Zhang, Z., Chen, L., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010341 · Cited by 14

Interaction of cancer cell-derived Foxp3 and tumor microenvironment in human tongue squamous cell carcinoma

Li, K., Huang, S.-H., Lao, X., Yang, L., Liao, G., & Liang, Y. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.07.029 · Cited by 13

Cytokine profile of CD4+CD25−FoxP3+ T cells in tumor-draining lymph nodes from patients with breast cancer

Niakan, A., Faghih, Z., Talei, A., & Ghaderi, A. A. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.10.007 · Cited by 13

Phloretin Modulates Human Th17/Treg Cell Differentiation In Vitro via AMPK Signaling

Jiao, A., Yang, Z., Fu, X., & Hua, X. (2020) · BioMed Research International · doi:10.1155/2020/6267924 · Cited by 13

Serum level of interleukin‐35 as a potential prognostic factor for gastric cancer

Gu, J., Wang, X., Wang, L., Zhou, L., Tang, M., Li, P., Wu, X., Chen, M., & Zhang, Y. (2020) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13403 · Cited by 13

RAI14 Is a Prognostic Biomarker and Correlated With Immune Cell Infiltrates in Gastric Cancer

Yu, X., Zhang, H., Du, G., Meng, X., Wu, T., Zhou, Q., Wang, Y., & Tan, B. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820970684 · Cited by 13

Immune-related long non-coding RNAs can serve as prognostic biomarkers for clear cell renal cell carcinoma

Li, C. S., Lu, Z. Z., Fang, D. L., Zhou, W. J., & Wei, J. (2021) · Translational Andrology and Urology · doi:10.21037/tau-21-445 · Cited by 13

Construction of a Novel Immune-Related lncRNA Pair Signature with Prognostic Significance for Kidney Clear Cell Renal Cell Carcinoma

Sun, J., Xia, Q., Liu, C., Xu, J., Xun, Y., Lu, J., Hu, J., & Wang, S. (2021) · Disease Markers · doi:10.1155/2021/8800358 · Cited by 13

NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients

Asl, K. D., Mazloumi, Z., Majidi, G., Kalarestaghi, H., Sabetkam, S., & Rafat, A. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3725 · Cited by 13

Integrating the tumor-suppressive activity of Maspin with p53 in retuning the epithelial homeostasis: A working hypothesis and applicable prospects

Tang, S., Ling, Z., Jiang, J., Gu, X. Q., Leng, Y., Wei, C., Cheng, H., & Li, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1037794 · Cited by 13

Construction and systematic evaluation of a machine learning-based cuproptosis-related lncRNA score signature to predict the response to immunotherapy in hepatocellular carcinoma

Lu, D., Liao, J., Cheng, H., Ma, Q., Wu, F., Xie, F., & He, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1097075 · Cited by 12

Translational Studies Using the MALT1 Inhibitor ( S )-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer

Pilato, M. D., Gao, Y., Sun, Y., Fu, A., Graß, C., Seeholzer, T., Feederle, R., Mazo, I. B., Kazer, S. W., Litchfield, K., et al. (2023) · Journal of Immunotherapy and Precision Oncology · doi:10.36401/jipo-22-18 · Cited by 13

Cancer‐derived non‐coding RNAs endow tumor microenvironment with immunosuppressive properties

Hu, T., Shi, R., Gu, Y., Zhou, H., Fang, Y., Xu, T., Xu, Y., Wu, X., Ma, L., & Shu, Y. (2023) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1822 · Cited by 14

Human regulatory T cells (Treg) and their response to cancer

Whiteside, T. L. (2019) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2019.1634471 · Cited by 14

Traf6 inhibitor boosts antitumor immunity by impeding regulatory T cell migration in Hepa1-6 tumor model

Wu, X. F., Xue, R., Peng, H., Gan, X., Lu, X., Yan, W., Tian, Y., Ni, X., Shen, H., Cheng, F., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105965 · Cited by 15

Pharmacological mechanisms of traditional Chinese medicine metabolites in regulating Treg cells: an integrative pathway review

Wang, C., Liao, M.-J., Wu, Y., Lin, H., Ye, Z.-Z., Ma, W., & Yuan, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1527421 · Cited by 12

The therapeutic effect of IL-21 combined with IFN-γ inducing CD4+CXCR5+CD57+T cells differentiation on hepatocellular carcinoma

Zhao, C., Wu, X., Chen, J., & Qian, G. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.05.010 · Cited by 12

RANKL and RANK in Cancer Therapy

Onji, M., & Penninger, J. M. (2022) · Physiology · doi:10.1152/physiol.00020.2022 · Cited by 14

Nanomaterials-involved strategies for reversing the immunosuppressive factors and improving antitumor immunotherapy

Gao, F., Dong, J., Xue, C., An, L., Zhang, T., Wang, W.-J., Ou, C., & Dong, X. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101831 · Cited by 12

Dual-responsive nanoparticles targeting bone microenvironment for synergistic chemoimmunotherapy of osteosarcoma by remodeling immune microenvironment

Li, J., Liao, S., Wu, Y., Bi, J., Han, Y., Zhang, Y., Xu, M. M., & Bi, W. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101877 · Cited by 12

Implications of Rectal Cancer Radiotherapy on the Immune Microenvironment: Allies and Foes to Therapy Resistance and Patients’ Outcome

Sartorius, D., Blume, M. L., Fleischer, J. R., Ghadimi, M. B., Conradi, L., & Oliveira, T. D. (2023) · Cancers · doi:10.3390/cancers15215124 · Cited by 11

SRSF10 facilitates HCC growth and metastasis by suppressing CD8+T cell infiltration and targeting SRSF10 enhances anti-PD-L1 therapy

Luo, X., Zhang, Z., Li, S., Wang, Y., Sun, M., Hu, D. X., Jiang, J., Wang, Y., Ji, X., Chen, X., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111376 · Cited by 12

A new target of radiotherapy combined with immunotherapy: regulatory T cells

Song, D., & Ding, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1330099 · Cited by 15

Combination of bulk RNA sequencing and scRNA sequencing uncover the molecular characteristics of MAPK signaling in kidney renal clear cell carcinoma

Li, X., Guan, H., Ma, C., Dai, Y., Su, J., Chen, X., Yuan, Q., & Wang, J. (2024) · Aging · doi:10.18632/aging.205436 · Cited by 12

Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker

Wang, S., Huang, X., Zhao, S., Lv, J., Li, Y., Wang, S., Guo, J., Wang, Y., Wang, R., Zhang, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1327565 · Cited by 12

Identification of Treg-related prognostic molecular subtypes and individualized characteristics in clear cell renal cell carcinoma through single-cell transcriptomes and bulk RNA sequencing

Weng, K. Q., Liu, J. Y., Hu, L., She, L. L., Qiu, J., Qi, H., Qi, H. Y., Li, Y.-S., & Dai, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111746 · Cited by 12

Applications of Intravital Imaging in Cancer Immunotherapy

Deng, D., Hao, T., Lu, L., Yang, M., Zeng, Z., Lovell, J. F., Liu, Y., & Jin, H. (2024) · Bioengineering · doi:10.3390/bioengineering11030264 · Cited by 13

Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer

Shanahan, S.-L., Kunder, N., Inaku, C., Hagan, N. B., Gibbons, G., Mathey‐Andrews, N., Anandappa, G., Soares, S. R. C., Pauken, K. E., Jacks, T., et al. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400268 · Cited by 14

RNA modifications in cancer immune therapy: regulators of immune cells and immune checkpoints

Qin, X., Liu, H., Zhang, Q., Che, Y., Lei, T., Tang, F., & Hu, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1463847 · Cited by 12

Advances in Antibody-Based Immune-Stimulating Drugs: Driving Innovation in Cancer Therapy

Zhao, R. R., & Fan, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041440 · Cited by 12

Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells

Ge, X., Zhao, Y., Chen, C., Wang, J., & Sun, L. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s231052 · Cited by 12

Philosophy of Immunology

Pradeu, T. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108616706 · Cited by 91

Cell‐Based Bio‐Hybrid Delivery System for Disease Treatments

Li, C., Qi, Y., Feng, J. X., & Zhang, X. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000052 · Cited by 12

Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity

Lou, Y., Wang, J., Peng, P., Wang, S., Liu, P., & Xu, L. X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189951 · Cited by 12

Inertial Microfluidic Purification of CAR‐T‐Cell Products

Elsemary, M. T., Maritz, M. F., Smith, L. E., Warkiani, M. E., Bandara, V., Nápoli, S., Barry, S. C., Coombs, J. T., & Thierry, B. (2021) · Advanced Biology · doi:10.1002/adbi.202101018 · Cited by 12

The expression pattern of Immune checkpoints after chemo/radiotherapy in the tumor microenvironment

Hassanian, H., Asadzadeh, Z., Baghbanzadeh, A., Derakhshani, A., Dufour, A., Khosroshahi, N. R., Najafi, S., Brunetti, O., Silvestris, N., & Baradaran, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.938063 · Cited by 12

Development and Validation of a Novel Mitochondrion and Ferroptosis-Related Long Non-Coding RNA Prognostic Signature in Hepatocellular Carcinoma

Xia, W., Zeng, C., Zheng, Z., Huang, C., Yu, Z., & Bai, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844759 · Cited by 12

Engineered Hybrid Treg-Targeted Nanosomes Restrain Lung Immunosuppression by Inducing Intratumoral CD8+T Cell Immunity

Domvri, K., Petanidis, S., Zarogoulidis, P., Anestakis, D., Charalampidis, C., Tsavlis, D., Huang, H., Freitag, L., Hohenforst‐Schmidt, W., Matthaios, D., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s346341 · Cited by 13

Prognostic implications of necroptosis-related long noncoding RNA signatures in muscle-invasive bladder cancer

Jiang, K., Wu, L., Yin, X., Tang, Q., Yin, J., Zhou, Z., Yu, H., & Yan, S. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1036098 · Cited by 12

Differential Benefit of Metronomic Chemotherapy Among Triple-Negative Breast Cancer Subtypes Treated in the IBCSG Trial 22–00

Garcia, A. J., Rediti, M., Venet, D., Majjaj, S., Kammler, R., Munzone, E., Gianni, L., Thurlimann, B. J. K., Laáng, I., Colleoni, M. A., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1267 · Cited by 12

Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice

Lippitsch, A., Baal, N., Chukovetskyi, Y., Cunningham, S., Michel, G., Dietert, K., Gurtner, C., Gruber, A. D., Bein, G., & Hackstein, H. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ab0119-014rr · Cited by 12

Histone Modifications as Biomarkers for Immunotherapy

Taylor, E. M., Koss, B. S., Davis, L. E., & Tackett, A. J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9773-2_10 · Cited by 12

Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of HNSCC with or without HPV infection.

Zhou, D., Wang, J., Wang, J., & Liu, X. (2021) · PubMed Central · Cited by 12

Immune profile analysis of peripheral blood and tumors of lung cancer patients treated with immune checkpoint inhibitors

Ichiki, Y., Fukuyama, T., Ueno, M., Kanasaki, Y., Goto, H., Takahashi, M., Mikami, S., Kobayashi, N., Nakanishi, K., Hayashi, S., et al. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-421 · Cited by 11

Regression in cutaneous melanoma: histological assessment, immune mechanisms and clinical implications

Aivazian, K. (2022) · Pathology · doi:10.1016/j.pathol.2022.11.005 · Cited by 12

Mechanisms, advances, and challenges of immunotherapy in gastric cancer

Wang, Z., & Wang, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639487 · Cited by 11

Intratumoral Injection of a Human Papillomavirus Therapeutic Vaccine-Induced Strong Anti-TC-1-Grafted Tumor Activity in Mice

Che, Y., Yang, Y., Suo, J., Chen, C., & Wang, X. (2021) · Cancer Management and Research · doi:10.2147/cmar.s329471 · Cited by 11

Role of Cytokines in Thymic Regulatory T Cell Generation: Overview and Updates

Tang, M., Jia, F., Nan, F., Zuo, F., Yuan, Z., & Zhang, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.883560 · Cited by 11

Phenotype, Function, and Clinical Significance of CD26+ and CD161+Tregs in Splenic Marginal Zone Lymphoma

Tang, X., Yang, Z.-Z., Kim, H. J., Anagnostou, T., Yu, Y., Wu, X., Chen, J., Krull, J. E., Wenzl, K., Mondello, P., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0977 · Cited by 11

CAR T Cell Therapy in Hematological Malignancies: Implications of the Tumor Microenvironment and Biomarkers on Efficacy and Toxicity

Tan, J. Y., Low, M. H., Chen, Y., & Lim, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136931 · Cited by 12

Targeting FGL2 in glioma immunosuppression and malignant progression

Ma, X., Zhu, H., Cheng, L., Chen, X., Shu, K., & Zhang, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1004700 · Cited by 11

Single-cell RNA-Seq and bulk RNA-Seq reveal reliable diagnostic and prognostic biomarkers for CRC

Zhang, X., Yang, L., Deng, Y., Huang, Z., Huang, H., Wu, Y., He, B., & Hu, F. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04882-0 · Cited by 13

Glucose metabolism reprogramming promotes immune escape of hepatocellular carcinoma cells

Zhang, Q., Liu, J., Lin, H., Lin, B., Zhu, M., & Li, M. (2023) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2023.00149 · Cited by 11

Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer

Wu, J., Wang, X., Li, Z., Yi, X., Hu, D., Wang, Q., & Zhong, T. (2024) · Cell Cycle · doi:10.1080/15384101.2024.2311501 · Cited by 11

Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis

Wang, Y., Chen, X., Tang, N., Guo, M., & Ai, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074134 · Cited by 11

Foxp3+ Treg control allergic skin inflammation by restricting IFN-γ-driven neutrophilic infiltration and NETosis

Tong, X., Kim, S. H., Che, L., Park, J., Lee, J., & Kim, T.-G. (2024) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2024.05.002 · Cited by 13

The role of extracellular vesicles in immune cell exhaustion and resistance to immunotherapy

Aghakhani, A., Pezeshki, P. S., & Rezaei, N. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2360209 · Cited by 11

Regulatory and memory T lymphocytes infiltrating prostate tumors predict long term clinical outcomes

Molina, O. E., LaRue, H., Simonyan, D., Hovington, H., Vittrant, B., Têtu, B., Fradet, V., Lacombe, L., Bergeron, A., & Fradet, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1372837 · Cited by 11

Potential mechanisms and targeting strategies of the gut microbiota in antitumor immunity and immunotherapy

Yin, Q., Ni, J., & Ying, J. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1263 · Cited by 12

Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

Serrano, A., Casares, N., Trocóniz, I. F., Lozano, T., Lasarte, J. J., Zalba, S., & Garrido, M. J. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01338-0 · Cited by 11

Cancer-associated SF3B1-K700E mutation controls immune responses by regulating T reg function via aberrant Anapc13 splicing

Shi, Y., Zhang, W., Jia, Q., Zhong, X., Iyer, P. S., Wu, H., Yuan, Y., Zhao, Y., Zhang, L., Wang, L., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado4274 · Cited by 11

CD38 modulates cytokine secretion by NK cells through the Sirt1/NF-κB pathway, suppressing immune surveillance in colorectal cancer

Wang, X., Song, X., Fang, K., & Chang, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-79008-8 · Cited by 13

CD4 + FOXP3Exon2 + regulatory T cell frequency predicts breast cancer prognosis and survival

Fusco, C., Rella, F. D., Liotti, A., Colamatteo, A., Ferrara, A. L., Gigantino, V., Collina, F., Esposito, E., Donzelli, I., Porcellini, A., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr7934 · Cited by 13

Self-oxygenating nanoplatform integrating CRISPR/Cas9 gene editing and immune activation for highly efficient photodynamic therapy

Tian, S.-C., Song, X.-H., Feng, K.-K., Li, C., Tu, Y., Hu, Y., & Shao, J. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137632 · Cited by 11

Mitochondria‐to‐Nucleus Trafficking NIR‐II Type I AIE Photosensitizer Synergistically Activates cGAS‐STING Pathway for Efficient Tumor Eradication

Ma, C., Zhuang, J., Jia, J., Li, B., He, Y., Huo, L., Li, N., & Zhao, N. (2025) · Small · doi:10.1002/smll.202503994 · Cited by 12

Can the microbiota predict response to systemic cancer therapy, surgical outcomes, and survival? The answer is in the gut

Bairi, K. E., Jabi, R., Trapani, D., Boutallaka, H., Bencheikh, B. O. A., Bouziane, M., Amrani, M., Afqir, S., & Maleb, A. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1758063 · Cited by 11

An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer

Xing, X., Jia, S., Leng, Y., Wang, Q., Li, Z., Dong, B., Guo, T., Cheng, X., Du, H., Hu, Y., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1792038 · Cited by 11

The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside

Gan, J., Zheng, S. J., Mao, X. R., & Li, J. F. (2020) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5478 · Cited by 11

Tumor microenvironment-associated gene C3 can predict the prognosis of colorectal adenocarcinoma: a study based on TCGA

Liu, Y., & Wang, X. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02602-z · Cited by 11

Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities

Rezaei, M., Danilova, N. D., Soltani, M., Savvateeva, L. V., Tarasov, V. V., Ganjalıkhani-Hakemi, M., Bazhin, A. V., & Zamyatnin, A. A. (2022) · Current Cancer Drug Targets · doi:10.2174/1568009622666220214103533 · Cited by 11

Tracing New Landscapes in the Arena of Nanoparticle-Based Cancer Immunotherapy

Nadukkandy, A. S., Ganjoo, E., Singh, A. K., & Kumar, L. D. (2022) · Frontiers in Nanotechnology · doi:10.3389/fnano.2022.911063 · Cited by 12

Immuno-onco-metabolism and Therapeutic Resistance

Mir, M. A., Aisha, S., Nisar, S., Qayoom, H., & Mehraj, U. (2022) · Springer eBooks · doi:10.1007/978-981-16-6226-3_3 · Cited by 11

Construction of an endoplasmic reticulum stress-related gene model for predicting prognosis and immune features in kidney renal clear cell carcinoma

Shen, Y., Cao, Y., Zhou, L., Wu, J., & Mao, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.928006 · Cited by 12

A comprehensive analysis focusing on cuproptosis to investigate its clinical and biological relevance in uterine corpus endometrial carcinoma and its potential in indicating prognosis

Wu, Q., Tian, R., Tan, H. L. E., Liu, J., Ou, C., Li, Y., & Fu, X. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1048356 · Cited by 11

Assessment of Diagnosis, Prognosis and Immune Infiltration Response to the Expression of the Ferroptosis-Related Molecule HAMP in Clear Cell Renal Cell Carcinoma

Leng, J., Xing, Z., Li, X., Bao, X., Zhu, J., Zhao, Y., Wu, S., & Yang, J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20020913 · Cited by 11

Targeting Treg cells in cancer immunotherapy

Tanaka, A., & Sakaguchi, S. (2019) · European Journal of Immunology · doi:10.1002/eji.201847659 · Cited by 484

Targeting Regulatory T Cells for Cancer Immunotherapy

Fuerst, M. L. (2016) · Oncology Times · doi:10.1097/01.cot.0000508329.83580.01

Regulatory T cells in tumor immunity

Nishikawa, H., & Sakaguchi, S. (2010) · International Journal of Cancer · doi:10.1002/ijc.25429 · Cited by 944

Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy

Tay, C., Tanaka, A., & Sakaguchi, S. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.014 · Cited by 614

Abstract A058: Selective targeting of T regulatory cells by a TCR-mimic monoclonal antibody specific for foxp3-derived epitopes

Dao, T., Jarvis, C. A., Scott, A., Korontsvit, T., Zakhaleva, V., Pankov, D., Guerrerio, M. D. D. M., Mathias, M. D., Cheng, N. N., Liu, C., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.imm2016-a058