Regulatory T cells in cancer immunotherapy

Tanaka, Atsushi, Sakaguchi, Shimon·2017·Cell Research

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Items 401–500 of 1,001

  1. STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets
    Dev M. Bhatt, Boxi Kang, Deepali V. Sawant, Liangtao Zheng, Kristy C. Perez, Zhiyu Huang, Laura Sekirov, Daniel J. Wolak, Julie Y. Huang, Xian Liu et al. · 2021 · The Journal of Experimental Medicine
  2. Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment
    Kexiang Sun, Linguangjin Wu, Shuyun Wang, Wanli Deng · 2022 · Frontiers in Oncology
  3. Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy
    Tianye Li, Xinrun Wang, Mengke Niu, Mingli Wang, Jianwei Zhou, Kongming Wu, Ming Yi · 2023 · Frontiers in Immunology
  4. Fibroblast diversity and plasticity in the tumor microenvironment: roles in immunity and relevant therapies
    Yashi Xu, Wei Li, Shitong Lin, Binghan Liu, Peng Wu, Li Li · 2023 · Cell Communication and Signaling
  5. Immune regulation by CD8+ Treg cells: novel possibilities for anticancer immunotherapy
    Shuping Zhang, Meng Yin Wu, Fang Wang · 2018 · Cellular and Molecular Immunology
  6. Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review
    Yolla Haibe, Ziad El Husseini, Rola El Sayed, Ali I. Shamseddine · 2020 · International Journal of Molecular Sciences
  7. Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity
    Ryuhei Okada, Takuya Kato, Aki Furusawa, Fuyuki F. Inagaki, Hiroaki Wakiyama, Peter L. Choyke, Hisataka Kobayashi · 2021 · Advanced Therapeutics
  8. MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment
    Jialin Song, Zaihuan Lin, Qing Liu, Sihao Huang, Lei Han, Yan Fang, Panyi Zhong, Rongzhang Dou, Zhenxian Xiang, Jinsen Zheng et al. · 2022 · Clinical and Translational Medicine
  9. Pan-cancer analyses and molecular subtypes based on the cancer-associated fibroblast landscape and tumor microenvironment infiltration characterization reveal clinical outcome and immunotherapy response in epithelial ovarian cancer
    Ruoyao Zou, Qidi Jiang, Tianqiang Jin, Mo Chen, Liangqing Yao, Hongda Ding · 2022 · Frontiers in Immunology
  10. Tumor immune microenvironment in endometrial cancer of different molecular subtypes: evidence from a retrospective observational study
    Yibo Dai, Luyang Zhao, Dingchao Hua, Lina Cui, Xiaobo Zhang, Nan Kang, Linlin Qu, Liwei Li, He Li, Danhua Shen et al. · 2022 · Frontiers in Immunology
  11. Activating CD8+ T Cells by Pt(IV) Prodrug‐Based Nanomedicine and aPD‐L1 Antibody for Enhanced Cancer Immunotherapy
    Bin Wang, Jingyu Zhou, Ruitong Li, Dongsheng Tang, Zheng Cao, Chun Xu, Haihua Xiao · 2024 · Advanced Materials
  12. Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity
    Xue-Hui Long, Su-Lin Zhang, Yu-Liang Wang, Jing-Jing Chen, Yan-Lai Lu, Hui Hou, Bichun Lin, Xu-Tong Li, Chang Shen, Rui-Rui Yang et al. · 2024 · Nature Immunology
  13. Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision
    Patrick Adair, Yong Chan Kim, Ai-Hong Zhang, Jeongheon Yoon, David William Scott · 2017 · Frontiers in Immunology
  14. Immunology of HPV-mediated cervical cancer: current understanding
    Babban Jee, Renu Yadav, Sangeeta Pankaj, Shivendra Kumar Shahi · 2020 · International Reviews of Immunology
  15. Therapeutic Updates for Relapsed and Refractory Classical Hodgkin Lymphoma
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  16. Advances in siRNA delivery strategies for the treatment of MDR cancer
    Md Abdus Subhan, Sara Aly Attia, Vladimir P. Torchilin · 2021 · Life Sciences
  17. Expanding role of PI5P4Ks in cancer: A promising druggable target
    Gurpreet K. Arora, Lavinia Palamiuc, Brooke M. Emerling · 2021 · FEBS Letters
  18. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy
    Xin He, Guangchao He, Zhaoxing Chu, Huanhuan Wu, Junjie Wang, Yiran Ge, Hui Shen, Shan Zhang, Jinxi Shan, Kewen Peng et al. · 2021 · Journal of Medicinal Chemistry
  19. Development of Anti-Mouse CC Chemokine Receptor 3 Monoclonal Antibodies for Flow Cytometry
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  20. The potential role of m6A modifications on immune cells and immunotherapy
    Linchuan Gan, Yuxiang Zhao, Yajuan Fu, Qi Chen · 2023 · Biomedicine & Pharmacotherapy
  21. Serine Metabolic Reprogramming in Tumorigenesis, Tumor Immunity, and Clinical Treatment
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  22. In Vitro Modeling of the Tumor Microenvironment in Tumor Organoids
    Mahesh Devarasetty, Steven Donald Forsythe, Ethan Shelkey, Shay Söker · 2020 · Tissue Engineering and Regenerative Medicine
  23. Remodeling of Tumor Immune Microenvironment by Oncolytic Viruses
    Bin Zhang, Xilei Wang, Ping Cheng · 2021 · Frontiers in Oncology
  24. Differential Role of PD-1 Expressed by Various Immune and Tumor Cells in the Tumor Immune Microenvironment: Expression, Function, Therapeutic Efficacy, and Resistance to Cancer Immunotherapy
    Myeong Joon Kim, Sang‐Jun Ha · 2021 · Frontiers in Cell and Developmental Biology
  25. Research advance of natural products in tumor immunotherapy
    Jin‐Ling Huo, Wen-Jia Fu, Zheng-Han Liu, Nan Lü, Xiang-Qian Jia, Zhangsuo Liu · 2022 · Frontiers in Immunology
  26. The role and significance of VEGFR2+ regulatory T cells in tumor immunity
    Panrong Zhu, Chenxi Hu, Kaiyuan Hui, Xiaodong Jiang · 2017 · OncoTargets and Therapy
  27. Interleukin‐33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells
    Yifan Xiao, Lin Lai, Huo-Ying Chen, Junyu Shi, Fan-Fan Zeng, Jun Li, Hui-Ting Feng, Jie Mao, Feng Zhang, Naming Wu et al. · 2018 · Molecular Immunology
  28. Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells
    Wen Liu, Tiancong Wu, Dongmei Hong, Yue Hu, Ting Fan, Wenjie Guo, Qiang Xu · 2018 · Chinese Journal of Natural Medicines
  29. Treg-dependent immunosuppression triggers effector T cell dysfunction via the STING/ILC2 axis
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  30. Engineered Cytokines for Cancer and Autoimmune Disease Immunotherapy
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  31. Gene therapy with regulatory T cells: A beneficial alliance
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  32. Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry
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  33. Regulatory T cells in gastric cancer: Key controllers from pathogenesis to therapy
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  34. EMT-induced immune evasion: connecting the dots from mechanisms to therapy
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  35. The immunosuppressive landscape in tumor microenvironment
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  36. Advances and clinical applications of immune checkpoint inhibitors in hematological malignancies
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  37. The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
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  38. The ratio of CD8 + lymphocytes to tumor-infiltrating suppressive FOXP3 + effector regulatory T cells is associated with treatment response in invasive breast cancer
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  39. T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma
    Daniele Maggioni, Lorenzo Pignataro, Werner Garavello · 2017 · OncoImmunology
  40. Using MRI cell tracking to monitor immune cell recruitment in response to a peptide‐based cancer vaccine
    Marie‐Laurence Tremblay, Christa Davis, Chris V. Bowen, Olivia Stanley, Cathryn Parsons, Genevieve Weir, Mohan Karkada, Marianne M. Stanford, Kimberly Brewer · 2017 · Magnetic Resonance in Medicine
  41. Role of exosomes in the immune microenvironment of ovarian cancer (Review)
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  42. Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis
    Xueqi Yan, Yinghong Xie, Fan Yang, Yijia Hua, Tianyu Zeng, Chunxiao Sun, Mengzhu Yang, Xiang Huang, Hao Wu, Ziyi Fu et al. · 2021 · Journal of Experimental & Clinical Cancer Research
  43. Immunopeptidomics-Guided Warehouse Design for Peptide-Based Immunotherapy in Chronic Lymphocytic Leukemia
    Annika Nelde, Yacine Maringer, Tatjana Bilich, Helmut Rainer Salih, Malte Roerden, Jonas S. Heitmann, Ana Marcu, Jens Bauer, Marian Christoph Neidert, Claudio Denzlinger et al. · 2021 · Frontiers in Immunology
  44. Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment
    Janice L. Farlow, John Chad Brenner, Yu L. Lei, Steven Bennett Chinn · 2021 · Oral Oncology
  45. Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma
    Cong Liu, Dingwei Liu, Fangfei Wang, Yang Liu, Jun Xie, Jinliang Xie, Yong Xie · 2022 · Frontiers in Immunology
  46. Crosstalk between gut microbiota and metastasis in colorectal cancer: implication of neutrophil extracellular traps
    Jiawei Wu, Wenyan Dong, Yayun Pan, Jingjing Wang, Minliang Wu, Yue Yu · 2023 · Frontiers in Immunology
  47. Stigmasterol: Remodeling gut microbiota and suppressing tumor growth through Treg and CD8+ T cells in hepatocellular carcinoma
    Ran Huo, Wenjing Yang, Yu Liu, Te Liu, Tong Li, Chu-Yu Wang, Beili Wang, Bei-Li Wang, Wei Guo · 2023 · Phytomedicine
  48. Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging
    Nan-jie Zhou, Wei-Qian Bao, Cuifen Zhang, Menglin Jiang, Tu-Liang Liang, Gang-Yuan Ma, Liang Liu, Hudan Pan, Run-Ze Li · 2025 · npj Aging
  49. The RANK–RANKL axis: an opportunity for drug repurposing in cancer?
    Solange Peters, Philippe Clézardin, Iván Márquez‐Rodas, Daniela Niepel, Craig A. Gedye · 2019 · Clinical & Translational Oncology
  50. Therapeutic Strategies for Overcoming Immunotherapy Resistance Mediated by Immunosuppressive Factors of the Glioblastoma Microenvironment
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  51. Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy
    Zhidi He, Meng Zhang, Yonghui Wang, Yang He, Hai-rui Wang, Binfan Chen, Bin Tu, Siqi Zhu, Yongzhuo Huang · 2020 · Acta Pharmacologica Sinica
  52. Recent advances in the development of AHR antagonists in immuno-oncology
    Lijun Sun · 2021 · RSC Medicinal Chemistry
  53. Implications of Tumor–Immune Coevolution on Cancer Evasion and Optimized Immunotherapy
    Jason Thomas George, Herbert Levine · 2021 · Trends in cancer
  54. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities
    Jianfeng Lou, Yuhang Lu, Jing Cheng, Feilong Zhou, Ziqin Yan, Daizhou Zhang, Xiangjing Meng, Yujun Zhao · 2022 · European Journal of Medicinal Chemistry
  55. Prognostic and Predictive Biomarkers in the Era of Immunotherapy for Lung Cancer
    Lucile Pabst, Sébastien Lopes, Basil Bertrand, Quentin Creusot, Maria Kotovskaya, Erwan Pencreach, Michèle Beau‐Faller, Céline Mascaux · 2023 · International Journal of Molecular Sciences
  56. Abscopal effect: from a rare phenomenon to a new frontier in cancer therapy
    Xueying Wang, Haoyu Zhang, XinZhang, Yong Hong Liu · 2024 · Biomarker Research
  57. The function and potential drug targets of tumour-associated Tregs for cancer immunotherapy
    Shanshan Yan, Yaguang Zhang, Bing Sun · 2019 · Science China Life Sciences
  58. Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance
    Yaqi Li, Jing Liu, Long Gao, Yuan Liu, Fang Meng, Xiaoan Li, Frank Xiao-Feng Qin · 2019 · Immunology Letters
  59. Phase I/II Pilot Study of Wilms' Tumor 1 Peptide‐Pulsed Dendritic Cell Vaccination Combined With Conventional Chemotherapy in Patients With Head and Neck Cancer
    Masahiro Ogasawara, Mamiko Miyashita, Yuka Yamagishi, Shuichi Ota · 2019 · Therapeutic Apheresis and Dialysis
  60. Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS
    Arjun Kalvala, Pierre Wallet, Lu Yang, Chongkai Wang, Haiqing Li, Arin Nam, Anusha Nathan, Isa Mambetsariev, Valeriy A. Poroyko, Hanlin Gao et al. · 2019 · Journal of Clinical Medicine
  61. TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models
    Katherine B. Case, Lisa Tran, Michael B. Yang, Hui Zheng, Willem M. Kühtreiber, Denise Louise Faustman · 2020 · Journal of Leukocyte Biology
  62. Systems biology analysis identifies TNFRSF9 as a functional marker of tumor-infiltrating regulatory T-cell enabling clinical outcome prediction in lung cancer
    Jae-Won Cho, Jimin Son, Sang‐Jun Ha, Insuk Lee · 2021 · Computational and Structural Biotechnology Journal
  63. Prognostic significance of tumor-infiltrating lymphocytes and macrophages in nasopharyngeal carcinoma: a systematic review and meta-analysis
    Weixing Liu, Chen Gui, Chunyi Zhang, Xiao Liao, Junyang Xie, Tianhao Liang, Wenjing Liao, Lijuan Song, Xiaowen Zhang · 2021 · European Archives of Oto-Rhino-Laryngology
  64. CD29 Enriches for Cytotoxic Human CD4+ T Cells
    Benoît P. Nicolet, Aurélie Guislain, Monika C. Wolkers · 2021 · The Journal of Immunology
  65. Endometriotic Peritoneal Fluid Stimulates Recruitment of CD4+CD25highFOXP3+ Treg Cells
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  66. Emerging role for thymic stromal lymphopoietin–responsive regulatory T cells in colorectal cancer progression in humans and mice
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  67. Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation
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  68. Diverse intratumoral heterogeneity and immune microenvironment of two HPV‐related cervical cancer types revealed by single‐cell RNA sequencing
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  69. Hepatocellular Carcinoma Immunotherapy: Predictors of Response, Issues, and Challenges
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  70. Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells
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  71. CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells
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  72. Biomarkers, measured during therapy, for response of melanoma patients to immune checkpoint inhibitors: a systematic review
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  73. Phosphoinositide 3‐kinase δ is a regulatory T‐cell target in cancer immunotherapy
    Ee Lyn Lim, Klaus Okkenhaug · 2019 · Immunology
  74. Functional T cell activation by smart nanosystems for effective cancer immunotherapy
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  75. Expression of costimulatory and inhibitory receptors in FoxP3+ regulatory T cells within the tumor microenvironment: Implications for combination immunotherapy approaches
    Aras Toker, Pamela S. Ohashi · 2019 · Advances in cancer research
  76. Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies
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  77. Development and validation of a metastasis-related Gene Signature for predicting the Overall Survival in patients with Pancreatic Ductal Adenocarcinoma
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  78. Antibody-based cancer immunotherapy by targeting regulatory T cells
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  79. A Novel TGF-β Risk Score Predicts the Clinical Outcomes and Tumour Microenvironment Phenotypes in Bladder Cancer
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  80. Immunostimulant citrus fruit-derived extracellular vesicle nanodrugs for malignant glioma immunochemotherapy
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  81. Infiltrating treg reprogramming in the tumor immune microenvironment and its optimization for immunotherapy
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  82. Lactylation: The metabolic accomplice shaping cancer's response to radiotherapy and immunotherapy
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  83. Immunomodulatory effects of anti-diabetic therapies: Cytokine and chemokine modulation by metformin, sodium-glucose cotransporter 2 inhibitors, and glucagon-like peptide-1 receptor agonists (2013-2025).
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  84. Overcoming resistance to PD-1 and CTLA-4 blockade mechanisms and therapeutic strategies
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  85. NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death
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  86. Exploration of the Combination of PLK1 Inhibition with Immunotherapy in Cancer Treatment
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  87. IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1
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  88. Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis
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  89. PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity
    Alessandro Poli, Shidqiyyah Abdul-Hamid, Antonio Enrico Zaurito, Francesca Campagnoli, Valeria Bevilacqua, Bhavwanti Sheth, Roberta Fiume, Massimiliano Pagani, Sergio Abrignani, Nullin Divecha · 2021 · Proceedings of the National Academy of Sciences
  90. Development of an Oxidative Phosphorylation-Related and Immune Microenvironment Prognostic Signature in Uterine Corpus Endometrial Carcinoma
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  91. Immunostimulatory Properties of Chemotherapy in Breast Cancer: From Immunogenic Modulation Mechanisms to Clinical Practice
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  92. Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma
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  93. Survival of the fittest: Cancer challenges T cell metabolism
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  94. Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma
    Naofumi Mukaida, Yasunari Nakamoto · 2018 · World Journal of Gastroenterology
  95. Microbiota: Overview and Implication in Immunotherapy-Based Cancer Treatments
    Giovanni Brandi, Giorgio Frega · 2019 · International Journal of Molecular Sciences
  96. The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis
    Ziyi Chen, Yue Wang, Xi Ding, Meng Zhang, Mingqian He, Yang Zhao, Shiqian Hu, Fengyi Zhao, Jingya Wang, Baosong Xie et al. · 2019 · Endocrine Journal
  97. MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity
    Eros Di Giorgio, Liqing Wang, Yan Xiong, Tatiana Akimova, Lanette M. Christensen, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Tricia R Bhatti, Ulf Henning Beier et al. · 2020 · Journal of Clinical Investigation
  98. Immune Checkpoint Blockade in Gynecologic Cancers: State of Affairs
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  99. Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery
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  100. Curcumin analog GO‐Y030 boosts the efficacy of anti‐PD‐1 cancer immunotherapy
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