Global profiling of crotonylation on non-histone proteins

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

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Acetylation and deacetylation of non-histone proteins

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Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

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Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

Sabari, B. R., Tang, Z., Huang, H., Yong-Gonzalez, V., Molina, H., Kong, H. E., Dai, L., Shimada, M., Cross, J. R., Zhao, Y., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.029 · Cited by 659

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

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Cross-regulation of histone modifications

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Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

Bao, X., Wang, Y., Li, X., Li, X.-M., Liu, Z., Yang, T., Wong, C. F., Zhang, J., Hao, Q., & Li, X. D. (2014) · eLife · doi:10.7554/elife.02999 · Cited by 324

YEATS2 is a selective histone crotonylation reader

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Profiling of Substrates for Zinc‐dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro

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Additional file 3 of Proteome-Wide Analyses Reveal the Diverse Functions of Lysine 2-Hydroxyisobutyrylation in Oryza sativa

Xue, C., Qiao, Z., Chen, X., Cao, P., Liu, K., Liu, S., Lu, Y., & Gong, Z. (2020) · Figshare · doi:10.6084/m9.figshare.12544352

Additional file 12 of Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature

Lin, P., Bai, H., He, L., Huang, Q., Zeng, Q.-H., Pan, Y., Jiang, B., Zhang, F., Zhang, L., & Liu, Q. (2021) · Figshare · doi:10.6084/m9.figshare.13578642

Novel protein acylations in Alzheimer’s disease: Molecular, mechanisms, biological significance, and diagnostic and therapeutic potentials

Yang, Y., Yu, Z., Gao, R., Zhang, Y., Zhang, Z., Zhong, X., Jiao, L., Du, K., Wu, Y., Wei, M., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.050 · Cited by 1

Additional file 1 of Proteome-Wide Analyses Reveal the Diverse Functions of Lysine 2-Hydroxyisobutyrylation in Oryza sativa

Xue, C., Qiao, Z., Chen, X., Cao, P., Liu, K., Liu, S., Lu, Y., & Gong, Z. (2020) · Figshare · doi:10.6084/m9.figshare.12544340

Additional file 2 of Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature

Lin, P., Bai, H.-R., He, L., Huang, Q.-X., Zeng, Q.-H., Pan, Y.-Z., Jiang, B.-B., Zhang, F., Zhang, L., & Liu, Q.-L. (2021) · Figshare · doi:10.6084/m9.figshare.13578657

Additional file 1 of Crotonylation of GAPDH regulates human embryonic stem cell endodermal lineage differentiation and metabolic switch

Zhang, J., Shi, G. W., Pang, J., Zhu, X., 冯庆彩, Na, J., Ma, W., Liu, D., & Songyang, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22621465

Additional file 1 of PlantNh-Kcr: a deep learning model for predicting non-histone crotonylation sites in plants

Jiang, Y., Yan, R., & Wang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26681284

Additional file 15 of Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature

Lin, P., Bai, H.-R., He, L., Huang, Q.-X., Zeng, Q.-H., Pan, Y.-Z., Jiang, B.-B., Zhang, F., Zhang, L., & Liu, Q.-L. (2021) · Figshare · doi:10.6084/m9.figshare.13578651

Additional file 1 of Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature

Lin, P., Bai, H.-R., He, L., Huang, Q.-X., Zeng, Q.-H., Pan, Y.-Z., Jiang, B.-B., Zhang, F., Zhang, L., & Liu, Q.-L. (2021) · Figshare · doi:10.6084/m9.figshare.13578654

Additional file 2 of SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival

Zhang, X.-Y., Liu, Z., Zhang, Y.-F., Xu, L.-X., Chen, M.-K., Zhou, Y.-F., Yu, J., Li, X.-X., & Zhang, N. (2024) · Figshare · doi:10.6084/m9.figshare.26576756

Additional file 1 of SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival

Zhang, X.-Y., Liu, Z., Zhang, Y.-F., Xu, L.-X., Chen, M.-K., Zhou, Y.-F., Yu, J., Li, X., & Zhang, N. (2024) · Figshare · doi:10.6084/m9.figshare.26576753

Lysine crotonylation coordinates osmotic stress response in Populus davidiana × P. bolleana through synergistic metabolic and transcriptional regulation

Wang, P., Miao, Z., Li, H., Zhou, M., Li, X., Wang, C., & Wang, Y. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.122580

Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors

Jiang, J., Chen, J., Huang, S., Tian, Y., Liu, L., Yao, J., Zhang, Y., Jiang, C., Zhang, X., Han, N., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02707-4

Proteomic landscape of crotonylation and acetylation in pig testes across male reproduction

Wang, L., Ao, H., Niu, X., Zhai, L., Liu, J., Wang, C., & Xing, K. (2026) · Journal of Proteomics · doi:10.1016/j.jprot.2026.105628

Emerging trends in protein post-translational modifications of lysine associated with plant stress and development

Wang, H., Ma, Y., Jin, M., Wang, C., Wang, K., Zheng, Y., Guo, L., Liu, X., Cui, Y., & Zhang, H. (2026) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2026.111232

CPT1B K321 crotonylation contributes to cardiac dysfunction in endotoxic shock

Yang, N., Yang, J., Xu, Y.-F., Huang, X., Gu, Y., Wen, R., Yang, Y., Hao, P.-H., Yang, X.-R., Liu, C.-F., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01730-2

HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis

Li, D., Cai, Q., Lin, L., Li, L., Chen, Y., Feng, T., Zhou, X. Y., Xie, J., Fu, X., Li, C., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1759160

Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis

He, X., Lv, M., Chen, J., Zhu, Q., Zhao, J., & Chen, W. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-10055-z

MOF promotes venous thromboembolism in lung cancer by activating the YBX1–MALT1–NF-κB–PAI-1 axis, possibly through histone crotonylation

Liu, Y., Yu, F., & Jiang, J. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113348

The role of ageing-specific PTM remodeling in myocardial ischemia-reperfusion injury

Liu, Q., Luo, Q., Zhong, S., Liu, Y., Yang, S., Zhu, M., Zhai, W., Yang, W., Qiang, F., Ye, L., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103279

DFN-kcr: a dual-branch deep learning model with attention-guided fusion for predicting lysine crotonylation sites in human non-histone proteins

Wei, X., Hu, S., & Lin, C. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1877411

Crosstalk between crotonylation and other post-translational modifications: Enlightening a promising avenue in disease regulation

Yang, X., Gong, G., Zhao, Y., Wang, G., & Zhang, F. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102390

HDA15-Mediated Deacetylation of GPX1 Inhibits Its Nuclear Translocation and Increases Osmotic Stress Sensitivity in Rice

Zhai, F., Ma, X., Li, W., Fan, X., Zhang, J., Zhou, H., & Xie, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167073

Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer

Chen, S.-J., Yue, S.-W., Zhang, Y.-P., Liang, H., Wu, H.-X., Chen, X., Zhang, B.-X., & Zhang, W. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02862-7 · Cited by 2

Emerging acylations in malignancies: Molecular mechanisms, research advances, and clinical implications

Henghui, Y., Huang, J., Wang, Y., Meng, J., Fan, W., Shao, Y., Zhang, X., & Wang, S. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105567

The Trajectory of Epigenetic Chromatin Remodeling in Cardiometabolic Disease and its Therapeutic Implications

Mačvanin, M., & Klisic, A. N. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10820-5

CAB39 K196 Decrotonylation Drives Psoriasis Pathogenesis by Modulating Keratinocyte Proliferation and Glycolysis

梁慧芳, Li, J., Jing, W., & Zhang, K. (2026) · Journal of Cellular Physiology · doi:10.1002/jcp.70224

Post-translational acylation of proteins in colorectal cancer

Xu, F., Wang, S., Le, Y., Chen, C., Zhang, M., & Tang, J. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101457

KAT-Net: a hyperbolic routing framework for joint lysine acylation site prediction with shared sequence–structure representations

Wu, H., Lin, Y., Zhu, L., Wang, Y., Chang, S., & Yang, S. (2026) · Briefings in Bioinformatics · doi:10.1093/bib/bbag567

Roles of protein crotonylation in tumors: regulatory mechanisms and therapeutic potential

Liang, Y., Liu, Q., Yang, C., Xun, Y., Liu, Y., Shen, Y., & Zu, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1952793

BindingDB Entry 50013116: Single-step fluorescent probes to detect decrotonylation activity of HDACs through intramolecular reactions.

BindingDB (2022) · UC San Diego · doi:10.7270/q2pg1wfm

The Function and related Diseases of Protein Crotonylation

Wang, S., Mu, G., Qiu, B., Wang, M., Yu, Z., Wang, W., Wang, J., & Yang, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.58872 · Cited by 53

Protein crotonylation: Basic research and clinical diseases

Li, D., Lin, L., Xu, F., Feng, T., Tao, Y., Miao, H., & Yang, F. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101694 · Cited by 8

Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions

Wei, W., Mao, A., Tang, B., Zeng, Q., Gao, S., Liu, X., Lu, L., Li, W., Du, J. X., Li, J., et al. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00012 · Cited by 163

Emerging roles of non-histone protein crotonylation in biomedicine

Hou, J., Zhou, L., Li, J., Wang, D., & Cao, J. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00616-2 · Cited by 44

Research Progress on Crotonylation in Malignant Tumor

Fangyuan, L., & Su, L. (2023) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3971/j.issn.1000-8578.2023.22.0770