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Untitled work

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Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms

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SIRT4 is the last puzzle of mitochondrial sirtuins

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LC–MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes

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Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

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The Function and related Diseases of Protein Crotonylation

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Targeting Sirtuins: Substrate Specificity and Inhibitor Design

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Effects of Histone Modification in Major Depressive Disorder

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The mechanisms, regulations, and functions of histone lysine crotonylation

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Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs

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Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

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Role of Sirtuins in Tumor Angiogenesis

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The Contribution of Histone Crotonylation to Tissue Health and Disease: Focus on Kidney Health

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Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity

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Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2- epi-Azumamide E and β3-epi-Azumamide E

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Supramolecular Affinity Labeling of Histone Peptides Containing Trimethyllysine and Its Application to Histone Deacetylase Assays

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Novel thiourea-based sirtuin inhibitory warheads

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One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

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Crotonylation and disease: Current progress and future perspectives

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Novel histone modifications and liver cancer: emerging frontiers in epigenetic regulation

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Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature

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Chemical editing of macrocyclic natural products and kinetic profiling reveal slow, tight-binding histone deacetylase inhibitors with picomolar affinities

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Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

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New chemical tools for probing activity and inhibition of the NAD + -dependent lysine deacylase sirtuin 2

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Distinct biochemical properties of the class I histone deacetylase complexes

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A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action

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Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma

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Regulatory Mechanism of Protein Crotonylation and Its Relationship with Cancer

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Characterizing crosstalk in epigenetic signaling to understand disease physiology

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Human SIRT3 tripeptidic inhibitors containing Nε-thioacetyl-lysine

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Dynamics and Functional Interplay of Nonhistone Lysine Crotonylome and Ubiquitylome in Vascular Smooth Muscle Cell Phenotypic Remodeling

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Methyl Effect in Azumamides Provides Insight Into Histone Deacetylase Inhibition by Macrocycles

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An Update on Lysine Deacylases Targeting the Expanding “Acylome”

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An azumamide C analogue without the zinc-binding functionality

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Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

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Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets

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Protein lysine crotonylation in cellular processions and disease associations

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Photo Cross‐Linking Probes Containing ϵ‐ <i>N</i> ‐Thioacyllysine and ϵ‐ <i>N</i> ‐Acyl‐(δ‐aza)lysine Residues

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Metabolic and epigenetic regulation of endoderm differentiation

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Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

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Protein Post-Translational Modifications Based on Proteomics: A Potential Regulatory Role in Animal Science

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Crotonylation modification and its role in diseases

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Role of Histone Lactylation in Neurological Disorders

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Single-step fluorescent probes to detect decrotonylation activity of HDACs through intramolecular reactions

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High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays

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Novel sirtuin inhibitory warheads derived from the N ε -acetyl-lysine analog l -2-amino-7-carboxamidoheptanoic acid

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Function and mechanism of lysine crotonylation in health and disease

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Protein crotonylation: An emerging regulator in DNA damage response

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Peptide‐Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real‐Time Detection of Lysine Deacylation

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Application of crotonylation modification in pan-vascular diseases

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Protein lysine four‐carbon acylations in health and disease

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Histone crotonylation in tumors (Review)

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Protein crotonylation: Basic research and clinical diseases

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Emerging posttranslational modifications and their roles in DNA damage response

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Distribution and diversity of classical deacylases in bacteria

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Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post‐Translational Modification

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The role of CddA and cGNAT2 in crotonylation of proteins in cyanobacteria

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Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

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Novel protein acylations in ferroptosis: decoding the regulatory roles of lactylation, crotonylation, succinylation, and β-hydroxybutyrylation

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Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms

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The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation

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Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs

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Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates

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