Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

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Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML

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Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I−/− iPSCs for β cell replacement

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A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products

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MiR-29c downregulates tumor-expressed B7-H3 to mediate the antitumor NK-cell functions in ovarian cancer

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CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1

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Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma

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Pediatric medulloblastoma express immune checkpoint B7-H3

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Pan-Cancer Interrogation of B7-H3 ( CD276 ) as an Actionable Therapeutic Target Across Human Malignancies

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Association of B7‐H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer

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The miR-29 family facilitates the activation of NK-cell immune responses by targeting the B7-H3 immune checkpoint in neuroblastoma

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CD276 as a novel CAR NK‐92 therapeutic target for neuroblastoma

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Tumor B7-H3 expression in diagnostic biopsy specimens and survival in patients with metastatic prostate cancer

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Phytochemicals in regulating PD ‐1/ PD‐L1 and immune checkpoint blockade therapy

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The current and emerging immunotherapy paradigm in small-cell lung cancer

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B7-H3: A promising therapeutic target for autoimmune diseases

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Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity

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Exploring the Mechanisms Underlying the Cardiotoxic Effects of Immune Checkpoint Inhibitor Therapies

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Immune checkpoint molecules in neuroblastoma: A clinical perspective

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The Glycosylation of Immune Checkpoints and Their Applications in Oncology

Zheng, L., Yang, Q., Li, F., Zhu, M., Yang, H., Tan, T., Wu, B., Liu, M.-X., Xu, C., Yin, J., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121451 · Cited by 26

B7-H3 in Cancer Immunotherapy—Prospects and Challenges: A Review of the Literature

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CAR T targets and microenvironmental barriers of osteosarcoma

Zhu, J., Simayi, N., Wan, R., & Huang, W. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.12.010 · Cited by 27

Highly proliferative and hypodifferentiated CAR-T cells targeting B7–H3 enhance antitumor activity against ovarian and triple-negative breast cancers

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Gastric Carcinomas with Stromal B7-H3 Expression Have Lower Intratumoural CD8+ T Cell Density

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Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer

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Identification and Validation of an 11-Ferroptosis Related Gene Signature and Its Correlation With Immune Checkpoint Molecules in Glioma

Chen, Z., Wu, T., Yan, Z., & Zhang, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.652599 · Cited by 26

Knockdown of lncRNA MCM3AP-AS1 Attenuates Chemoresistance of Burkitt Lymphoma to Doxorubicin Treatment via Targeting the miR-15a/EIF4E Axis

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A Novel Treatment for Ewing’s Sarcoma: Chimeric Antigen Receptor-T Cell Therapy

Lin, Z., Wu, Z., & Luo, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707211 · Cited by 26

Advanced Acral Melanoma Therapies: Current Status and Future Directions

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CAR T-cells to treat brain tumors

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Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo

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High B7‐H3 expression is linked to increased risk of prostate cancer progression

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Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers

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Alternative Checkpoints as Targets for Immunotherapy

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Targeting novel immune checkpoints in the B7-H family: advancing cancer immunotherapy from bench to bedside

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Neuroblastoma in the Era of Precision Medicine: A Clinical Review

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Improved antitumor effects elicited by an oncolytic HSV-1 expressing a novel B7H3nb/CD3 BsAb

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Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging

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miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review

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Biomaterials‐Boosted Immunotherapy for Osteosarcoma

Sun, C., Li, S., & Ding, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400864 · Cited by 25

Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment

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B7-H3 modulates endothelial cell angiogenesis through the VEGF cytokine

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B7-H3 confers resistance to Vγ9Vδ2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis

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Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules

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B7-H3 and its role in bone cancers

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Frequent B7-H3 overexpression in craniopharyngioma

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Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades

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Tumor immune checkpoints and their associated inhibitors

Gao, Z., Ling, X., Shi, C., Wang, Y., & Lin, A. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200195 · Cited by 21

A glycolysis-related gene signatures in diffuse large B-Cell lymphoma predicts prognosis and tumor immune microenvironment

Cui, Y., & Leng, C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1070777 · Cited by 21

Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma

Liang, J., Liu, Z., Pei, T., Xiao, Y., Zhou, L., Tang, Y., Zhou, C., Wu, K., Zhang, F., Zhang, F., et al. (2020) · Disease Markers · doi:10.1155/2020/5354825 · Cited by 20

An Inflammatory Response Related Gene Signature Associated with Survival Outcome and Gemcitabine Response in Patients with Pancreatic Ductal Adenocarcinoma

Xiao, Z., Jin-yin, L., Yu, Q., Zhou, T., Duan, J., Yang, Z., Liu, C., & Xu, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.778294 · Cited by 20

Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study

Inthanachai, T., Boonkrai, C., Phakham, T., Pisitkun, T., Thaiwong, R., Chuthaphakdikun, V., Sakunrangsit, N., Limprasutr, V., Chinsuwan, T., Hirankarn, N., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010083 · Cited by 23

Blocking PD-1/PD-L1 by an ADCC enhanced anti-B7-H3/PD-1 fusion protein engages immune activation and cytotoxicity

Xu, Y., Xiao, Y. Z., Luo, C., Liu, Q., Wei, A., Yang, Y., Zhao, L., & Wang, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106584 · Cited by 20

Multi-Omics Data Analyses Identify B7-H3 as a Novel Prognostic Biomarker and Predict Response to Immune Checkpoint Blockade in Head and Neck Squamous Cell Carcinoma

Lin, W., Xu, Y., Gao, J., Zhang, H., Sun, Y., Qiu, X., Huang, Q., Kong, L., & Lu, J. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.757047 · Cited by 21

Targeting cancer stem cells in multiple myeloma

Gunes, E. G., Gunes, M., Yu, J., & Janakiram, M. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.06.002 · Cited by 19

Clinical progress of B7-H3 targeted antibody drug conjugate ifinatamab deruxtecan for small-cell lung cancer

Wespiser, M., Gille, R., & Pérol, M. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2512566 · Cited by 18

Prognostic value of prognostic nutritional index score and controlling nutritional status score in patients with glioblastoma: A comprehensive meta-analysis

Peng, J., Li, X., Huang, M., Ma, M., Huang, Q., Huang, N., & Cheng, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1117764 · Cited by 18

Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities

Li, H.-Y., Chen, Y., Deng, X., Li, H., Tan, J., Liu, G., Zheng, Y., Pei, M., Peng, K.-T., Yue, L.-L., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01118-2 · Cited by 21

Hub gene of disulfidptosis-related immune checkpoints in breast cancer

Wang, Y., Deng, Y., Xie, H., & Cao, S. (2023) · Medical Oncology · doi:10.1007/s12032-023-02073-y · Cited by 18

Polymorphisms of nucleotide factor of activated T cells cytoplasmic 2 and 4 and the risk of acute rejection following kidney transplantation

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The evolving landscape of antibody-drug conjugates (ADCs) for treatment of prostate cancer

Lin, C., Hadfield, M. J., Santopietro, A., Lagos, G., Cheng, L., El-Deiry, W. S., Aggarwal, R., Mega, A., Hyams, E., & Carneiro, B. A. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01131-0 · Cited by 20

CAR NK Cell Therapy for the Treatment of Metastatic Melanoma: Potential & Prospects

Hibler, W., Merlino, G. T., & Yu, Y. (2023) · Cells · doi:10.3390/cells12232750 · Cited by 17

A promising target for breast cancer: B7-H3

Jiang, Y., Liu, J., Chen, L., Qian, Z., & Zhang, Y. (2024) · BMC Cancer · doi:10.1186/s12885-024-11933-3 · Cited by 18

T cell cytotoxicity toward hematologic malignancy via B7-H3 targeting

Sun, X., Yu, Y., Ma, L., Xue, X., Gao, Z., Ma, J., & Zhang, M. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00819-y · Cited by 16

Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas

Furuya, M., Iribe, Y., Nagashima, Y., Kambe, N., Ohe, C., Kinoshita, H., Sato, C., Kishida, T., Okubo, Y., Numakura, K., et al. (2020) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2020-206548 · Cited by 17

Expression status of PD‐L1 and B7‐H3 in mesothelioma

Matsumura, E., Kajino, K., Abe, M., Ohtsuji, N., Saeki, H., Hlaing, M. T., & Hino, O. (2020) · Pathology International · doi:10.1111/pin.13028 · Cited by 16

Multiplexed digital spatial profiling of invasive breast tumors from Black and White women

Omilian, A. R., Sheng, H., Hong, C., Bandera, E. V., Khoury, T., Ambrosone, C. B., & Yao, S. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13017 · Cited by 17

AAMP is a binding partner of costimulatory human B7-H3

Ciprut, S., Berberich, A., Knoll, M., Pusch, S., Hoffmann, D. C., Furkel, J., Ward, A., Kahlert-Konzelamnn, L., Sahm, F., Warnken, U. H., et al. (2022) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdac098 · Cited by 18

Monoclonal Antibodies in Dermatooncology—State of the Art and Future Perspectives

Bobrowicz, M., Zagożdżon, R., Domagała, J., Vasconcelos‐Berg, R., Guenova, E., & Winiarska, M. (2019) · Cancers · doi:10.3390/cancers11101420 · Cited by 17

Immunomodulatory effects of microwave ablation on malignant tumors

Xu, F. (2024) · American Journal of Cancer Research · doi:10.62347/qjid8425 · Cited by 17

Cyclin‑dependent kinase 9 expression and its association with CD8+ T cell infiltration in microsatellite‑stable colorectal cancer

Wang, J., Liu, J., Tian, F., Zhan, Y., & Kong, D. (2019) · Oncology Letters · doi:10.3892/ol.2019.10970 · Cited by 16

Comprehensive Analysis of Myeloid Signature Genes in Head and Neck Squamous Cell Carcinoma to Predict the Prognosis and Immune Infiltration

Liu, Z., Zhang, D., Liu, C., Li, G., Chen, H., Ling, H. H., Zhang, F., Huang, D., Wang, X., Liu, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659184 · Cited by 16

Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells

Zhang, D., Yu, Y., Ding, C., Zhang, R., Duan, T., & Zhou, Q. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac220 · Cited by 16

The New Immunotherapy Combinations in the Treatment of Advanced Non-Small Cell Lung Cancer: Reality and Perspectives

Rocco, D., Gravara, L. D., & Gridelli, C. (2019) · Current Clinical Pharmacology · doi:10.2174/1574884714666190809124555 · Cited by 16

Cell-Surface GRP78-Targeted Chimeric Antigen Receptor T Cells Eliminate Lung Cancer Tumor Xenografts

Wang, S., Wei, W., Yuan, Y., Guo, J., Liang, D., & Zhao, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010564 · Cited by 15

B7-H3 in the tumor microenvironment: Implications for CAR T cell therapy in pediatric solid tumors

Jansen, L., Wienke, J., Molkenbur, R., Rössig, C., & Meissner, R. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10294-y · Cited by 15

Mapping spatial heterogeneity in gastric cancer microenvironment

Wang, B., Song, B., Li, Y., Zhao, Q., & Tan, B. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116317 · Cited by 15

B7‐H3‐Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns

Ding, M., Liao, H., Zhou, N., Yang, Y., Guan, S., & Chen, L. (2020) · BioMed Research International · doi:10.1155/2020/8824805 · Cited by 14

Elevated Expression of the Immune Checkpoint Ligand CD276 (B7-H3) in Urothelial Carcinoma Cell Lines Correlates Negatively with the Cell Proliferation

Harland, N., Maurer, F. B., Abruzzese, T., Bock, C., Montes-Mojarro, I. A., Fend, F., Aicher, W. K., Stenzl, A., & Amend, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094969 · Cited by 13

A Novel Immune-Related Gene Prognostic Index (IRGPI) in Pancreatic Adenocarcinoma (PAAD) and Its Implications in the Tumor Microenvironment

Zhou, S., Szöllősi, A. G., Huang, X., Chien, Y.-C. C., & Hajdú, A. (2022) · Cancers · doi:10.3390/cancers14225652 · Cited by 14

Cancer Cell B7-H3 Expression Is More Prevalent in the Pancreato-Biliary Subtype of Ampullary Cancer Than in Pancreatic Cancer

Geerdes, E. E., Sideras, K., Aziz, M. H., van Eijck, C. H. J., Bruno, M. J., Sprengers, D., Boor, P. P. C., & Kwekkeboom, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.615691 · Cited by 13

Influence of ADT on B7-H3 expression during CRPC progression from hormone-naïve prostate cancer

Kang, N., Xue, H., Lin, Y., Dong, X., Classen, A., Wu, R., Jin, Y., Lin, D., Volik, S. V., Ong, C. J., et al. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00644-9 · Cited by 15

Dual Inhibition of B7-H3 and EGFR Overcomes Acquired Chemoresistance in Colon Adenocarcinoma

Chen, L.-C., Yang, P.-C., Chen, C.-Y., Chiang, S., Chen, T.-W., Chen, W. T., Ke, T., Liang, J., Shiau, A., Chao, K. S. C., et al. (2024) · Journal of Cancer · doi:10.7150/jca.91089 · Cited by 13

B7 Family Members in Lymphoma: Promising Novel Targets for Tumor Immunotherapy?

Zhang, W., Qiu, Y., Xie, X., Fu, Y. S., Wang, L., & Cai, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.647526 · Cited by 13

Inhibition of the B7-H3 immune checkpoint limits hepatocellular carcinoma progression by enhancing T lymphocyte-mediated immune cytotoxicity in vitro and in vivo

Zhou, Z., Yu, X., Chen, Y., Tan, X., Liu, W., Hua, W., Chen, L., & Zhang, W. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-03013-4 · Cited by 12

Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients

Sun, J., Lai, H., Shen, D., Wu, P., Yang, J., Sun, Z., & Guo, Y. (2017) · Journal of Immunology Research · doi:10.1155/2017/5728512 · Cited by 13

Expression of Programmed Death-Ligand 1 in Laryngeal Carcinoma and its Effects on Immune Cell Subgroup Infiltration

Yu, D., Cheng, J., Xue, K., Zhao, X., Wen, L., & Xu, C. (2018) · Pathology & Oncology Research · doi:10.1007/s12253-018-0501-x · Cited by 13

Genetically Modified T-Cell Therapy for Osteosarcoma: Into the Roaring 2020s

DeRenzo, C., & Gottschalk, S. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-43032-0_10 · Cited by 12

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody

Liu, X., Zhelev, D. V., Adams, C., Chen, C., Mellors, J. W., & Dimitrov, D. S. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101232 · Cited by 11

Clinical significance of B7-H3 and HER2 co-expression and therapeutic value of combination treatment in gastric cancer

Shao, X., Zhan, S., Quan, Q., Shen, Y., Chen, S., Zhang, X., Li, R., Liu, M., & Cao, L. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108988 · Cited by 12

Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors

Chapoval, A. I., Chapoval, S. P., Shcherbakova, N. S., & Щербаков, Д. Н. (2019) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162019050091 · Cited by 12

Expression patterns of the immune checkpoint ligand CD276 in urothelial carcinoma

Aicher, W. K., Korn, M., Reitnauer, L., Maurer, F. B., Hennenlotter, J., Black, P. C., Todenhöfer, T., Bedke, J., & Stenzl, A. (2021) · BMC Urology · doi:10.1186/s12894-021-00829-0 · Cited by 12

Targeted Therapy of B7 Family Checkpoints as an Innovative Approach to Overcome Cancer Therapy Resistance: A Review from Chemotherapy to Immunotherapy

Taghavi, B. A., Alizadeh, N., Saeedi, H., Ahangar, N. K., Derakhshani, A., Hajiasgharzadeh, K., Silvestris, N., Baradaran, B., & Brunetti, O. (2022) · Molecules · doi:10.3390/molecules27113545 · Cited by 12

Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

Lv, C., Han, S., Wu, B., Liang, Z., Li, Y., Zhang, Y., Lang, Q., Zhong, C., Fu, L., Yu, Y. W., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984172 · Cited by 12

Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas

Li, B., Guo, Y. H., Yi, Y., Huang, Z., Ren, Y., Wang, H., & Yang, L. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04489-6 · Cited by 11

The State of Cellular Adoptive Immunotherapy for Neuroblastoma and Other Pediatric Solid Tumors

Le, T.-P., & Thai, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01640 · Cited by 12

Challenges and unanswered questions for the next decade of immune-oncology research in NSCLC

Karachaliou, N., Fernández-Bruno, M., Bracht, J. W. P., & Rosell, R. (2018) · Translational Lung Cancer Research · doi:10.21037/tlcr.2018.06.08 · Cited by 10

Advanced Molecular Characterization Using Digital Spatial Profiling Technology on Immunooncology Targets in Methylated Compared with Unmethylated IDH-Wildtype Glioblastoma

Barber, H. R., Tofias, A., Lander, B., Daniels, A. R., Gong, J., Ren, Y., Ren, X., Liang, Y., White, P., & Kurian, K. M. (2021) · Journal of Oncology · doi:10.1155/2021/8819702 · Cited by 12

The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages

Park, R., Yu, J., Shahzad, M., Lee, S., & Ji, J. D. (2024) · Immunologic Research · doi:10.1007/s12026-024-09458-9 · Cited by 11

Comprehensive Analysis Reveals Distinct Immunological and Prognostic Characteristics of CD276/B7-H3 in Pan-Cancer

Ding, J., Sun, Y., Sulaiman, Z., Li, C., Cheng, Z., & Liu, S. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s395553 · Cited by 11

Abstract 494: Novel human B7-H3 knock-in mice demonstrate efficacy of anti-B7-H3 immunotherapy in vivo

Zhao, L., Li, H., Liu, Y., Yu, Z.-X., & Lin, E. (2021) · Cancer Research · doi:10.1158/1538-7445.am2021-494

Inhibition of the B7-H3 immune checkpoint limits hepatocellular carcinoma progression by enhancing T lymphocyte-mediated immune cytotoxicity in vitro and in vivo

Zhou, Z., Yu, X., Chen, Y., Tan, X., Liu, W., Hua, W., Chen, L., & Zhang, W. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-03013-4 · Cited by 12

New checkpoints in cancer immunotherapy

Ni, L., & Dong, C. (2017) · Immunological Reviews · doi:10.1111/imr.12524 · Cited by 143

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3

Kanchan, R. K., Doss, D., Κhan, P., Nasser, M. W., & Mahapatra, S. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188783 · Cited by 44

Mouse B7-H3 induces antitumor immunity

Sun, X., Vale, M., Leung, E. Y., Kanwar, J. R., Gupta, R., & Krissansen, G. W. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302070 · Cited by 131