Single-cell proteomics takes centre stage
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Single-cell mass spectrometry, including single-cell proteomics and single-cell metabolomics, provides protein and metabolite identification on a large scale.
“One method that has yet to be used to study senescence is single-cell mass spectrometry, including single-cell proteomics and single-cell metabolomics which provide protein (including post-translational modification) and metabolite identification on a large scale [37] and could have enormous implications for studying senescent cells.”
From The heterogeneity of cellular senescence: insights at the single-cell level (2023) · cites this paper as [37]
Cites
Deep proteome and transcriptome mapping of a human cancer cell line
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Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation
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TMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing
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Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbationPreprint
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Exploring functional protein covariation across single cells using nPOPPreprint
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CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics
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The heterogeneity of cellular senescence: insights at the single-cell level
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- Authors
- Perkel, J. M.
- Corresponding author
- Perkel, Jeffrey M.
- ORCID
- Perkel, Jeffrey M.
- Venue
- Nature
- Published
- 2021-09-20
- Volume
- 597
- Issue
- 7877
- Pages
- 580-582
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3199418278
- Cited by
- 92
- References
- 18
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 20 · 2023: 23 · 2022: 30 · 2021: 3 · 2020: 1
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Keywords
- single-cell proteomics, proteome, single-cell analysis, protein expression
- MeSH terms
- Cell Cycle, Humans, Neurons, Mass Spectrometry, Protein Isoforms, Proteome, Proteomics, Single-Cell Analysis, Transcriptome
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