Effect of changes in waist circumference on metabolic syndrome over a 6.6-year follow-up in Tehran
Abstract
Background/objectives This cohort study was conducted to evaluate the effect of waist change on metabolic syndrome (MetS) status and its parameters in 5720 participants, aged >or=20 years, of the Tehran Lipid and Glucose Study who were followed up for a mean of 6.6 years.Subjects/methods We measured waist circumference (WC) and MetS parameters at baseline (phase I: 1999) and at follow-up (phase III: 2008), and assessed this relationship across five groups: waist loss (<-2.0 cm); waist stable (-2.0 to 2.9 cm); mild (3.0-5.9 cm); moderate (6.0-8.9 cm) and large (>or=9.0 cm) waist gain. MetS was defined according to the International Diabetes Federation criteria.Results In phase I, the mean (s.d.) waist gain was 88.8 cm (11.7). Between phases I and III, the mean (s.d.) waist gain was 5 cm (7.9). There was 16% (95% confidence interval (95% CI): 13.6-18.4) age-adjusted incident MetS and for every centimeter of WC gained over 6.6 years, the risk of MetS increased by 10% (odds ratio (OR) 1.10; 95% CI: 1.09-1.12). Compared with a stable WC in both genders, ORs for MetS for different waist gain groups were as follows: mild (OR 2.3, 95% CI: 1.7-3.2); moderate (OR 3.5, 95% CI: 2.6-4.7) and large (OR 5.8, 95% CI: 4.5-7.6). Waist loss had a protective effect on MetS (OR 0.6, 95% CI: 0.4-0.9). Waist gain showed a detrimental effect on all parameters of MetS in both genders, except for high-density lipoprotein cholesterol and fasting blood sugar in women.Conclusions Waist gain, even mild, was a risk factor of the development of MetS and its parameters. Intervention for reducing WC could be an effective strategy to decrease incident MetS.
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Even modest reductions in waist circumference (<2 cm) confer improvements in all metabolic risk factors.
“even modest reductions in WC (<2 cm) confer improvements in all metabolic risk factors, 86”
From What exercise prescription is optimal to improve body composition and cardiorespiratory fitness in adults living with obesity? A network meta‐analysis (2021) · cites this paper as [86]
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- Authors
- Hosseinpanah, F., Barzin, M., Mirmiran, P., & Azizi, F.
- Affiliations
- Research Institute for Endocrine Sciences (IR)
- Corresponding author
- Hosseinpanah, F
- Venue
- European Journal of Clinical Nutrition
- Published
- 2010-05-19
- Volume
- 64
- Issue
- 8
- Pages
- 879-886
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2039088536
- Cited by
- 13
- References
- 31
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2018: 3 · 2016: 1 · 2013: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- waist circumference, metabolic syndrome, abdominal obesity, incident metabolic syndrome, risk factors, Tehran Lipid and Glucose Study, HDL cholesterol, fasting blood glucose
- MeSH terms
- Adult, Blood Glucose, Female, Follow-Up Studies, Humans, Iran, Cholesterol, HDL, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, Odds Ratio, Metabolic Syndrome, Waist Circumference, Obesity, Abdominal
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