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Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME‐4, a coated‐pit protein

Sato, Miyuki, Sato, Ken, Liou, Willisa, Pant, Saumya, Harada, Akihiro, Grant, Barth D·2008·The EMBO Journal

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Crossref · 10.1038/emboj.2008.54

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  • The study extended the known Retromer regulators to include DENND4A and DENND4C, TBC1D13, and a TBC1D1/TBC1D4 heterodimer, establishing mechanistic links between Retromer and the switching of RAB10 and RAB35.

    “We have now extended these regulators to include DENND4A and DENND4C, TBC1D13, and a TBC1D1/TBC1D4 heterodimer, and in so doing, established mechanistic links between Retromer and the switching of RAB10 and RAB35; two RAB GTPases previously linked to the regulation of endosomal cargo recycling85,88–90,92,96,101,121,122.”
  • RAB35 regulates endosomal exit for cell surface recycling, in part through controlling localised actin dynamics and phosphoinositide metabolism.

    “RAB35 itself regulates endosomal exit for cell surface recycling95–99, in part through controlling localised actin dynamics and phosphoinositide metabolism100,101.”

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Research works printed but not linked: 39

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Metadata

Authors
Sato, M., Sato, K., Liou, W., Pant, S., Harada, A., & Grant, B. D.
Venue
The EMBO Journal
Published
2008-03-20
Volume
27
Issue
8
Pages
1183-1196
ISSN
  • 0261-4189
  • 1460-2075
Cited by
177
References
2
Language
en

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