Clathrin-independent pathways of endocytosis
Open accessAbstract
There are many pathways of endocytosis at the cell surface that apparently operate at the same time. With the advent of new molecular genetic and imaging tools, an understanding of the different ways by which a cell may endocytose cargo is increasing by leaps and bounds. In this review we explore pathways of endocytosis that occur in the absence of clathrin. These are referred to as clathrin-independent endocytosis (CIE). Here we primarily focus on those pathways that function at the small scale in which some have distinct coats (caveolae) and others function in the absence of specific coated intermediates. We follow the trafficking itineraries of the material endocytosed by these pathways and finally discuss the functional roles that these pathways play in cell and tissue physiology. It is likely that these pathways will play key roles in the regulation of plasma membrane area and tension and also control the availability of membrane during cell migration.
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Self-citationInterplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and recycling
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Filamin A Regulates Caveolae Internalization and Trafficking in Endothelial Cells
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Self-citationThe budding yeast endocytic pathway
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Self-citationFolate receptors targeted to clathrin-coated pits cannot regulate vitamin uptake.
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Bending "On the Rocks"--A Cocktail of Biophysical Modules to Build Endocytic PathwaysPreprint
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Induced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission
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Self-citationMURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis
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Gupta, G. D., Swetha, M. G., Kumari, S., Lakshminarayan, R., Dey, G., & Mayor, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006768 · Cited by 71 · see citing works
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Arl13b regulates endocytic recycling traffic
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Need Tension Relief Fast? Try Caveolae
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Self-citationThe budding yeast endocytic pathway
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To degrade or not to degrade: Mechanisms and significance of endocytic recycling
Cullen, P. J., & Steinberg, F. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0053-7 · Cited by 590 · see citing works
Factors influencing the blood-brain barrier permeability
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Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications
Xie, S., Zhang, Q., & Jiang, L. (2022) · Membranes · doi:10.3390/membranes12050498 · Cited by 262 · see citing works
Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface
Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062710 · Cited by 122 · see citing works
Self-citationMacropinocytosis, mTORC1 and cellular growth control
Yoshida, S., Pacitto, R., Inoki, K., & Swanson, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2710-y · Cited by 114 · see citing works
Insights of Endocytosis Signaling in Health and Disease
Pathak, C., Vaidya, F. U., Waghela, B. N., Jaiswara, P. K., Gupta, V. K., Kumar, A., Rajendran, B. K., & Ranjan, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032971 · Cited by 59 · see citing works
“Another concept for clathrin-independent endocytosis includes short, often crescentshaped tubular clathrin-independent carriers (CLICs) [9], which mature into early endocytic compartments (GEECs), enriched with glycosylphosphatidylinositol (GPI)-anchored protein [71].”
BackgroundCoupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation
Domingues, L., Hurbain, I., Gilles-Marsens, F., Sirés-Campos, J., André, N., Dewulf, M., Romao, M., Viaris de Lesegno, C., Macé, A.-S., Blouin, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16738-z · Cited by 53 · see citing works
Jaye, S., Sandau, U. S., & Saugstad, J. A. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1378576 · Cited by 26 · see citing works
Li, J., Lin, Y., Wang, X., & Lu, M. (2024) · Virologica Sinica · doi:10.1016/j.virs.2024.01.001 · Cited by 9 · see citing works
- Authors
- Mayor, S., Parton, R. G., & Donaldson, J. G.
- Affiliations
- Tata Institute of Fundamental Research (IN)
- The University of Queensland (AU)
- National Institutes of Health (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-06-01
- Volume
- 6
- Issue
- 6
- Pages
- a016758-a016758
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4031960
- OpenAlex
- W2041780927
- Cited by
- 525
- References
- 164
- Citations by year
- 2026: 26 · 2025: 19 · 2024: 36 · 2023: 32 · 2022: 43 · 2021: 70 · 2020: 79 · 2019: 60 · 2018: 51 · 2017: 37 · 2016: 30 · 2015: 29 · 2014: 11 · 2013: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- clathrin-independent endocytosis, caveolae, coated vesicles, membrane trafficking, membrane tension, cell migration, membrane recycling
- MeSH terms
- Cell Membrane, Clathrin, Endocytosis, Dynamins
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