Cited by 525Cellular transport and secretionCaveolin-1 and cellular processesAutophagy in Disease and Therapy

Clathrin-independent pathways of endocytosis

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Mayor, S., Parton, R. G., Donaldson, J. G.·2014·Cold Spring Harbor Perspectives in Biology

Abstract

There are many pathways of endocytosis at the cell surface that apparently operate at the same time. With the advent of new molecular genetic and imaging tools, an understanding of the different ways by which a cell may endocytose cargo is increasing by leaps and bounds. In this review we explore pathways of endocytosis that occur in the absence of clathrin. These are referred to as clathrin-independent endocytosis (CIE). Here we primarily focus on those pathways that function at the small scale in which some have distinct coats (caveolae) and others function in the absence of specific coated intermediates. We follow the trafficking itineraries of the material endocytosed by these pathways and finally discuss the functional roles that these pathways play in cell and tissue physiology. It is likely that these pathways will play key roles in the regulation of plasma membrane area and tension and also control the availability of membrane during cell migration.

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Crossref · 10.1101/cshperspect.a016758

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Authors
Mayor, S., Parton, R. G., & Donaldson, J. G.
Affiliations
  • Tata Institute of Fundamental Research (IN)
  • The University of Queensland (AU)
  • National Institutes of Health (US)
Venue
Cold Spring Harbor Perspectives in Biology
Published
2014-06-01
Volume
6
Issue
6
Pages
a016758-a016758
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2041780927
Cited by
525
References
164
Citations by year
2026: 26 · 2025: 19 · 2024: 36 · 2023: 32 · 2022: 43 · 2021: 70 · 2020: 79 · 2019: 60 · 2018: 51 · 2017: 37 · 2016: 30 · 2015: 29 · 2014: 11 · 2013: 2
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
clathrin-independent endocytosis, caveolae, coated vesicles, membrane trafficking, membrane tension, cell migration, membrane recycling
MeSH terms
Cell Membrane, Clathrin, Endocytosis, Dynamins

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