ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons
Kuhn, Peer‐Hendrik, Wang, Huanhuan, Dislich, Bastian, Colombo, Alessio, Zeitschel, Ulrike, Ellwart, Joachim W, Kremmer, Elisabeth, Roßner, Steffen +1 more·2010·The EMBO Journal
Cited by (624)
Items 101–200 of 624
- Mechanistic Link between Vitamin B12 and Alzheimer’s DiseaseAnna Andrea Lauer, Heike S. Grimm, Birgit Apel, Nataliya Golobrodska, Lara Kruse, Elina Ratanski, Noemi Schulten, Laura Schwarze, Thomas Slawik, Saskia Sperlich et al. · 2022 · Publications of the UdS (Saarland University)
- Risk factor SORL1: from genetic association to functional validation in Alzheimer’s diseaseOlav M. Andersen, Ina‐Maria Rudolph, Thomas E. Willnow · 2016 · Acta Neuropathologica
- Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpinsHani Goodarzi, Steven Zhang, Colin G. Buss, Lisa Fish, Saeed Tavazoie, Sohail F. Tavazoie · 2014 · Nature
- Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10Hamida Hammad, Matthias A. Vanderkerken, Philippe Pouliot, Kim Deswarte, Wendy Toussaint, Karl Vergote, Lana Vandersarren, Sophie Janssens, Ioanna Ramou, Savvas N. Savvides et al. · 2017 · Nature Immunology
- Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer's diseaseHassan Bukhari, Annika Glotzbach, Katharina Kolbe, Gregor Leonhardt, Christina Loosse, Thorsten Müller · 2017 · Progress in neurobiology
- Huntingtin and the SynapseBarron, Jessica C., Hurley, Emily P., Parsons, Matthew P. · 2021 · Frontiers in Cellular Neuroscience
- Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's DiseaseP. Agostinho, A. Pliássova, C. Oliveira, R. Cunha · 2015 · Journal of Alzheimer's Disease
- Diverse functions of the prion protein – Does proteolytic processing hold the key?Luise Linsenmeier, Hermann C. Altmeppen, Sebastian Wetzel, Behnam Mohammadi, Paul Säftig, Markus Glatzel · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse ModelsGloria Biella, Federica Fusco, Emanuele Nardo, Ottavia Bernocchi, Alessio Vittorio Colombo, Stefan F. Lichtenthaler, Gianluigi Forloni, Diego Albani · 2016 · Journal of Alzheimer s Disease
- Alzheimer’s disease: as it was in the beginningStanislav O. Kozlov, Alexey М. Afonin, Igor Evsyukov, А. Б. Бондаренко · 2017 · Reviews in the Neurosciences
- Calmodulin Binding Proteins and Alzheimer’s DiseaseDanton H. O’Day, Kristeen Eshak, Michael A. Myre · 2015 · Journal of Alzheimer s Disease
- Translational Repression of the Disintegrin and Metalloprotease ADAM10 by a Stable G-quadruplex Secondary Structure in Its 5′-Untranslated RegionSven Lammich, Frits Kamp, Judith Wagner, Brigitte Nuscher, Sonja Zilow, Ann‐Katrin Ludwig, Michael Willem, Christian Haass · 2011 · Journal of Biological Chemistry
- Synaptic dysfunction in early phases of Alzheimer's DiseaseSilvia Pelucchi, Fabrizio Gardoni, Mónica Di Luca, Elena E. Marcello · 2022 · Handbook of clinical neurology
- ADAM10 and BACE1 are localized to synaptic vesiclesJolanta L. Lundgren, Saheeb Ahmed, Sophia Schedin‐Weiss, Gunnar K. Gouras, Bengt G. Winblad, Lars O. Tjernberg, Susanne Frykman · 2015 · Journal of Neurochemistry
- ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral markerPatrícia Regina Manzine, Miren Ettcheto, Amanda C. Cano, Oriol Busquets, Elena E. Marcello, Silvia Pelucchi, Mónica Di Luca, Kristina Endres, Jordi Olloquequi, Antoni Camins et al. · 2019 · Biomedicine & Pharmacotherapy
- Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10Regina Augustin, Kristina Endres, Sven Reinhardt, Peer‐Hendrik Kuhn, Stefan F. Lichtenthaler, Jens Hansen, Wolfgang Wurst, Dietrich Trümbach · 2012 · BMC Medical Genetics
- Human stem cell–derived monocytes and microglia‐like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2Christel Claes, Johanna Van Den Daele, Ruben Boon, Sarah Schouteden, Alessio Vittorio Colombo, Laura Sebastián Monasor, Mark W. E. J. Fiers, Laura Ordovás, Fatemeharefeh Nami, Bernd Bohrmann et al. · 2018 · Alzheimer s & Dementia
- Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMPLaura García-González, Dominika Pilat, K. Baranger, S. Rivera · 2019 · Frontiers in Aging Neuroscience
- EpCAM proteolysis: new fragments with distinct functions?Ulrike Schnell, Jeroen Kuipers, Ben N. G. Giepmans · 2013 · Bioscience Reports
- Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivoJonathan R. Fisher, Clare E. Wallace, Danielle L. Tripoli, Yvette I. Sheline, John R. Cirrito · 2016 · Molecular Neurodegeneration
- Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 miceWang, Jun, Sun, Bin-Lu, Xiang, Yang, Tian, Ding-Yuan, Zhu, Chi, Li, Wei-Wei, Liu, Yu-Hui, Bu, Xian-Le, Shen, Lin-Lin, Jin, Wang-Sheng et al. · 2020 · Translational Psychiatry
- Regulation of alpha-secretase ADAM10 expression and activityKristina Endres, Falk Fahrenholz · 2011 · Experimental Brain Research
- Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiologyGrant Pfundstein, Alexander G. Nikonenko, Vladimir Sytnyk · 2022 · Frontiers in Cell and Developmental Biology
- Alzheimer culprits: Cellular crossroads and interplaySylvie Claeysen, Maud Cochet, Romain Donneger, Aline Dumuis, Joël Bockaert, Patrizia Giannoni · 2012 · Cellular Signalling
- SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammationJavier Rueda‐Carrasco, María Jesús Martín‐Bermejo, Guadalupe Pereyra, María Inés Mateo, Aldo Borroto, Frederic Brosseron, Markus P. Kummer, Stephanie Schwartz, José P. López‐Atalaya, Balbino Alarcón et al. · 2021 · EMBO Reports
- Identification and biology of α‐secretaseValérie Vingtdeux, P. Marambaud · 2012 · Journal of Neurochemistry
- Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s DiseaseB. Tang · 2020 · Toxics
- Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s DiseaseYunying Yang, Zhentao Zhang · 2020 · Frontiers in Aging Neuroscience
- Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell linesAlessio Vittorio Colombo, Huanhuan Wang, Peer‐Hendrik Kuhn, Richard Page, Elisabeth Kremmer, Peter J. Dempsey, Howard C. Crawford, Stefan F. Lichtenthaler · 2012 · Neurobiology of Disease
- Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and CalsynteninSimone Eggert, Carolin Thomas, Stefan Kins, Guido Hermey · 2017 · Molecular Neurobiology
- Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomersDaniela Kaden, Anja Harmeier, Christoph Weise, Lisa Marie Munter, Veit Althoff, Benjamin R. Rost, Peter Werner Hildebrand, Dietmar Schmitz, Michael Schaefer, Rudi Lurz et al. · 2012 · EMBO Molecular Medicine
- Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage siteCaroline Schönherr, Jessica Bien, Simone Isbert, Rielana Wichert, Johannes Prox, Hermann C. Altmeppen, Sathish Kumar, Jochen Walter, Stefan F. Lichtenthaler, Sascha Weggen et al. · 2016 · Molecular Neurodegeneration
- Amyloid Cascade Hypothesis for the Treatment of Alzheimer’s Disease: Progress and ChallengesTong Wu, Lin Ding, Ya‐Qian Cheng, Senze Jiang, Muhammad Waheed Riaz, Nina Fu, Chenhao Mou, Menglu Ye, Ying Zheng · 2022 · Aging and Disease
- Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's diseaseBenedikt Kretner, Johannes Trambauer, Akio Fukumori, Janina Mielke, Peer‐Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan F. Lichtenthaler, Christian Haass, Thomas Arzberger et al. · 2016 · EMBO Molecular Medicine
- Alzheimer's Disease‐Associated Ubiquilin‐1 Regulates Presenilin‐1 Accumulation and Aggresome FormationJayashree Viswanathan, Annakaisa Haapasalo, Claudia Böttcher, Riitta A. Miettinen, Kaisa M. A. Kurkinen, Alice Lu, Anne Thomas, Christa J. Maynard, Donna Romano, Bradley T. Hyman et al. · 2010 · Traffic
- Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s diseaseRiqiang Yan, Qingyuan Fan, John Zhou, Robert J. Vassar · 2016 · Neuroscience & Biobehavioral Reviews
- Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer’s diseaseHuiqin Li, Siu‐Po Ip, Qiuju Yuan, Guo‐qing Zheng, Karl Wah Keung Tsim, Tina Ting-Xia Dong, Ge Lin, Yifan Han, Yue Liu, Yan‐Fang Xian et al. · 2019 · Brain Behavior and Immunity
- Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X SyndromeEmanuela Pasciuto, Tariq Ahmed, Tina Wahle, Fabrizio Gardoni, Laura D’Andrea, Laura Pacini, Sébastien Jacquemont, Flora Tassone, Detlef Balschun, Carlos G. Dotti et al. · 2015 · Neuron
- BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous SystemNiklas Mattsson, Lawrence Rajendran, Henrik Zetterberg, Mikael K. Gustavsson, Ulf Andréasson, Maria Olsson, Gunnar Brinkmalm, Johan Lundkvist, Laura H. Jacobson, Ludovic Perrot et al. · 2012 · PLoS ONE
- A Novel Chimeric Oncolytic Virus Vector for Improved Safety and Efficacy as a Platform for the Treatment of Hepatocellular CarcinomaSarah Abdullahi, Melanie Jäkel, Sabine J. Behrend et al. · 2018 · Journal of Virology
- The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer’s DiseaseMeng Qian, Xiaoqiang Shen, Huanhuan Wang · 2015 · Cellular and Molecular Neurobiology
- ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor ProteinMarcia L. Moss, Gary Powell, Miles Aaron Miller, Lori L. Edwards, Bin Qi, Qing‐Xiang Amy Sang, Bart De Strooper, Ina C. Tesseur, Stefan F. Lichtenthaler, Mara Taverna et al. · 2011 · Journal of Biological Chemistry
- SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylationClaudia Saraceno, Elena E. Marcello, Daniele Di Marino, Barbara Borroni, Sylvie Claeysen, Julie Perroy, Alessandro Padovani, Anna Luna Tramontano, Fabrizio Gardoni, Mónica Di Luca · 2014 · Cell Death and Disease
- Chronic treatments with a 5-HT 4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's diseaseKévin Baranger, Patrizia Giannoni, Stéphane D. Girard, Sarah Girot, Florence Gaven, Delphine Stephan, Martine Migliorati, Michel Khrestchatisky, Joël Bockaert, E Marchetti et al. · 2017 · Neuropharmacology
- Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling PathwayXian-Zi Wan, Bei Li, Yi-Chen Li, Xiangling Yang, Wei Zhang, Ling Zhong, Shao-Jun Tang · 2012 · Journal of Neuroscience
- Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's diseaseNady Braidy, Musthafa Mohamed Essa, Anne Poljak, Selvaraju Subash, Samir Al‐Adawi, Thamilarasan Manivasagm, Arokiasamy Justin Thenmozhi, Lezanne Ooi, Perminder Singh Sachdev, Gilles J. Guillemin · 2016 · Oncotarget · Retracted
- 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in miceDivna Lazić, Abhay P. Sagare, Angeliki Maria Nikolakopoulou, John H. Griffin, Robert J. Vassar, Berislav V. Zloković · 2019 · The Journal of Experimental Medicine
- Degradome of soluble ADAM10 and ADAM17 metalloproteasesFranka Scharfenberg, Andreas O. Helbig, Martin Sammel, Julia Benzel, Uwe Schlomann, Florian Peters, Rielana Wichert, Maximilian Bettendorff, Dirk Schmidt‐Arras, Stefan Rose‐John et al. · 2019 · Cellular and Molecular Life Sciences
- Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat modelAsmaa M. Elfiky, Asmaa Ahmed Mahmoud, Hala A. Elreedy · 2021 · Life Sciences
- TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implicationsZhongya Gu, Huấn Cao, Chengchao Zuo, Yaqi Huang, Jinfeng Miao, Yu Song, Yuyan Yang, Liudi Zhu, Furong Wang · 2022 · Neurobiology of Disease
- Opposite effects of P2X7 and P2Y2nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cellsMíriam León‐Otegui, Rosa Gómez‐Villafuertes, Juan Ignacio Díaz‐Hernandéz, Miguel Dı́az-Hernández, M. Teresa Miras‐Portugal, Javier Gualix · 2011 · FEBS Letters
- Modeling Alzheimer’s disease: from past to futureClaudia Saraceno, Stefano Musardo, Elena E. Marcello, Silvia Pelucchi, Mónica Di Luca · 2013 · Frontiers in Pharmacology
- The Role of Cholesterol Metabolism in Alzheimer’s DiseaseSun, Jia-Hao, Yu, Jin-Tai, Tan, Lan · 2015 · Molecular Neurobiology
- ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin AChristian Herzog, Randy S. Haun, Andreas Ludwig, Sudhir V. Shah, Gur P. Kaushal · 2014 · Journal of Biological Chemistry
- ADAM10 as a Biomarker for Alzheimer’s Disease: A Study with Brazilian ElderlyPatrícia Regina Manzine, Jessyka Maria de França Bram, Elizabeth Joan Barham · 2013 · Dementia and Geriatric Cognitive Disorders
- Huperzine a alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic miceYing Wang, Xi Can Tang, Haiyan Zhang · 2011 · Journal of Neuroscience Research
- Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.I. Tesseur, Anna A. Pimenova, Adrian C. Lo, M. Ciesielska, S. Lichtenthaler, J. D. De Maeyer, J. Schuurkes, R. D'Hooge, B. de Strooper · 2013 · Neurobiology of Aging
- Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory SignalingJames David Londino, Dexter L. Gulick, Jeffrey Scott Isenberg · 2015 · Journal of Biological Chemistry
- ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer’s diseaseElena E. Marcello, Barbara Borroni, Silvia Pelucchi, Fabrizio Gardoni, Mónica Di Luca · 2017 · Expert Opinion on Therapeutic Targets
- ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's DiseaseFlorent Letronne, Geoffroy O. Laumet, Anne‐Marie Ayral, Julien Chapuis, Florie Demiautte, Mathias Laga, Michel Erminio Vandenberghe, Nicolas Malmanche, Florence Leroux, Fanny Eysert et al. · 2016 · EBioMedicine
- Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysisAllen C. Chen, Sumin Kim, Nina E. Shepardson, Sarvagna Patel, Soyon Youngae Hong, Dennis J. Selkoe · 2015 · The Journal of Cell Biology
- Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4Sandra Paschkowsky, Mehdi Hamzé, Felix Oestereich, Lisa Marie Munter · 2016 · Journal of Biological Chemistry
- Expression and Processing of Amyloid Precursor Protein in Vascular EndotheliumLivius V. d’Uscio, Tongrong He, Zvonimir S. Katušić · 2016 · Physiology
- Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer’s DiseaseJuan Ramón Perea, Alberto Lleó, Daniel Andres Alcolea, Juan Fortea, Jesús Ávila, Marta Bolós · 2018 · Frontiers in Neuroscience
- BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's diseaseMarta Del Campo, Jeroen J.M. Hoozemans, Lois-Lee Dekkers, Annemieke J.M. Rozemüller, Carsten Korth, Andreas Müller‐Schiffmann, Philip Scheltens, Marinus A. Blankenstein, Connie R. Jiménez, Robert Veerhuis et al. · 2014 · Neurobiology of Aging
- Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta productionRachel A. Rice, Nicole C. Berchtold, Carl W. Cotman, Kim N. Green · 2013 · Neurobiology of Aging
- Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous SystemKathryn M. Munro, Amelia Nash, Martina Pigoni, Stefan F. Lichtenthaler, Jenny Margaret Gunnersen · 2016 · Journal of Molecular Neuroscience
- Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarksReinhardt, Sven, Stoye, Nicolai, Luderer, Mathias, Kiefer, Falk, Schmitt, Ulrich, Lieb, Klaus, Endres, Kristina · 2018 · Scientific Reports
- Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trialsKrzysztof Drygalski, Eliza Fereniec, Krzysztof Koryciński, Andrzej Chomentowski, Aleksandra Kiełczewska, Cezary Odrzygóźdź, Beata Modzelewska · 2018 · Experimental Gerontology
- The role of proteases in regulating Eph/ephrin signalingLakmali Atapattu, Martin Lackmann, Peter W. Janes · 2014 · Cell Adhesion & Migration
- Calmodulin Binding Proteins and Alzheimer’s Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by CalmodulinDanton H. O’Day · 2020 · International Journal of Molecular Sciences
- Structural basis for membrane-proximal proteolysis of substrates by ADAM10Colin H. Lipper, Emily D. Egan, Khal-Hentz Gabriel, Stephen C. Blacklow · 2023 · Cell
- ER-stress in Alzheimer's disease: turning the scale?Kristina Endres, Sven Reinhardt · 2013 · Europe PMC (PubMed Central)
- Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and PresenilinJohannes Prox, Andrea Rittger, P. Saftig · 2011 · Experimental Brain Research
- DISC1 regulates trafficking and processing of APP and Aβ generationNeelam Shahani, Saurav Seshadri, Hanna Jaaro-Peled, K Ishizuka, Yuki Hirota-Tsuyada, Qi Wang, Minori Koga, Thomas W. Sedlak, Carsten Korth, Nicholas J. Brandon et al. · 2014 · Molecular Psychiatry
- Carnosic acid suppresses the production of amyloid-β 1–42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cellsPengfei Meng, Hidemi Yoshida, Tomoh Matsumiya et al. · 2012 · Neuroscience Research
- Neural stem/progenitor cells in Alzheimer's disease.Gizem Tincer, Violeta Mashkaryan, Prabesh Bhattarai, Çağhan Kızıl · 2016 · Europe PMC (PubMed Central)
- Therapeutic approaches in the improvement of cognitive performance in Down syndromede la Torre, Rafael, Dierssen, Mara · 2012 · Progress in Brain Research
- Dietary lipids and their oxidized products in Alzheimer's diseaseLaura Corsinovi, Fiorella Biasi, Giuseppe Poli, Gabriella Leonarduzzi, Giancarlo Isaia · 2011 · Molecular Nutrition & Food Research
- Endogenous and synthetic MMP inhibitors in CNS physiopathology.K. Baranger, S. Rivera, F. Liechti, D. Grandgirard, J. Bigas, Jesus Seco, T. Tarragó, S. Leib, M. Khrestchatisky · 2014 · Progress in Brain Research
- The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 PeptidesGabriele Siegel, Hermeto Gerber, Philipp Koch, Bruestle Oliver, Patrick C. Fraering, Lawrence Rajendran · 2017 · Cell Reports
- Redox signaling and metabolism in Alzheimer's diseaseMariana Inés Holubiec, Manuela Gellert, Eva-Maria Hanschmann · 2022 · Frontiers in Aging Neuroscience
- Shedding of APP limits its synaptogenic activity and cell adhesion propertiesStahl, Ronny, Schilling, Sandra, Soba, Peter, Rupp, Carsten, Hartmann, Tobias, Wagner, Katja, Merdes, Gunter, Eggert, Simone, Kins, Stefan · 2014 · Frontiers in Cellular Neuroscience
- Alzheimer disease: modeling an Aβ-centered biological networkDominique Campion, Cyril P. Pottier, Gaël Nicolas, Kilan Le Guennec, Anne Rovelet‐Lecrux · 2016 · Molecular Psychiatry
- MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitroK. Baranger, Amandine Bonnet, Stéphane D. Girard, Jean-Michel Paumier, Laura García-González, Wejdane Elmanaa, A. Bernard, E. Charrat, D. Stephan, Charlotte Bauer et al. · 2017 · Frontiers in Molecular Neuroscience
- Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cellsHidemi Yoshida, Pengfei Meng, Tomoh Matsumiya, Kunikazu Tanji, Ryo Hayakari, Fei Xing, Liang You Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura et al. · 2013 · Neuroscience Research
- Regulation of Amyloid Precursor Protein Processing by Serotonin SignalingAnna A. Pimenova, Amantha Thathiah, Bart De Strooper, Ina C. Tesseur · 2014 · PLoS ONE
- Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-SecretaseSebastian Hogl, Peer‐Hendrik Kuhn, Alessio Vittorio Colombo, Stefan F. Lichtenthaler · 2011 · PLoS ONE
- Depression in Alzheimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?Richard J. Elsworthy, Sarah Aldred · 2019 · Journal of Alzheimer s Disease
- CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathwayKotaro Furusawa, Toshiyuki Takasugi, Yung‐Wen Chiu, Yukiko Hori, Taisuke Tomita, Mitsunori Fukuda, Shin‐ichi Hisanaga · 2019 · Journal of Biological Chemistry
- New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)David Rosenbaum, Paul Säftig · 2023 · FEBS Journal
- The relationship between cholesterol level and Alzheimer’s disease-associated APP proteolysis/Aβ metabolismChao-Qun Wang, Yikai Shou, Jie Pan, Yue Du, Cui-Qing Liu, Huanhuan Wang · 2018 · Nutritional neuroscience
- Levels of ADAM10 are reduced in Alzheimer’s disease CSFAitana Sogorb‐Esteve, María‐Salud García‐Ayllón, Johan Gobom, Jordi Alom, Henrik Zetterberg, Kaj Blennow, Javier Sáez‐Valero · 2018 · Journal of Neuroinflammation
- Brothers in Arms: ProBDNF/BDNF and sAPPα/Aβ-Signaling and Their Common Interplay with ADAM10, TrkB, p75NTR, Sortilin, and sorLA in the Progression of Alzheimer’s DiseaseEggert, Simone, Kins, Stefan, Endres, Kristina, Brigadski, Tanja · 2022 · Biological Chemistry
- The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neuronsJing Zhi Anson Tan, Paul A. Gleeson · 2018 · Journal of Biological Chemistry
- Key Peptides and Proteins in Alzheimer’s DiseaseBotond Penke, Ferenc Bogár, Gábor Paragi, János Gera, Lívia Fülöp · 2019 · Current Protein and Peptide Science
- The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130Stephan A. Müller, Merav D. Shmueli, Xiao Ming Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose‐John, Matthew E Kennedy et al. · 2023 · Molecular Neurodegeneration
- Alzheimer's disease genes and autophagySeung‐Yong Yoon, Dong‐Hou Kim · 2016 · Brain Research
- NrCAM is a marker for substrate‐selective activation of ADAM10 in Alzheimer's diseaseTobias Brummer, Stephan A. Müller, Francisco J. Pan-Montojo, Fumiaki Yoshida, Andreas Fellgiebel, Taisuke Tomita, Kristina Endres, Stefan F. Lichtenthaler · 2019 · EMBO Molecular Medicine
- Soluble amyloid precursor protein α and β in CSF in Alzheimer's diseaseGunnar Brinkmalm, Ann Brinkmalm, Philippe Bourgeois, Rita Persson, Oskar Hansson, Erik Portelius, Marc H. Mercken, Ulf Andréasson, Stéphane Parent, Francesco Lipari et al. · 2013 · Brain Research