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Cited by 53Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Shedding of APP limits its synaptogenic activity and cell adhesion properties

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Stahl, Ronny, Schilling, Sandra, Soba, Peter, Rupp, Carsten, Hartmann, Tobias, Wagner, Katja, Merdes, Gunter, Eggert, Simone +1 more·2014·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2014.00410PMC PMC4253958
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Abstract

The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its extracellular domain. Since neuronal APP is extensively processed by secretases, it raises the question if APP shedding affects its cell adhesion and synaptogenic properties. We show that inhibition of APP shedding using cleavage deficient forms of APP or a dominant negative α-secretase strongly enhanced its cell adhesion and synaptogenic activity suggesting that synapse promoting function of APP is tightly regulated by α-secretase mediated processing, similar to other trans-cellular synaptic adhesion molecules.

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Authors
Stahl, R., Schilling, S., Soba, P., Rupp, C., Hartmann, T., Wagner, K., Merdes, G., Eggert, S., & Kins, S.
Affiliations
  • Heidelberg University (DE)
  • University of Kaiserslautern (DE)
  • Universität Hamburg (DE)
  • Saarland University (DE)
Corresponding author
Kins, Stefan
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2014-12-03
Volume
8
Pages
410-410
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2014.00410
PMC
PMC4253958
OpenAlex
W2077180114
Cited by
53
References
3
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 9 · 2018: 2 · 2017: 10 · 2016: 5 · 2015: 3
FWCI
3.74
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
  • ETH Zürich Research Collection (cc-by)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amyloid precursor protein, synaptogenesis, cell adhesion, alpha-secretase, Alzheimer's disease, synaptic adhesion molecules

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