ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

Kuhn, Peer‐Hendrik, Wang, Huanhuan, Dislich, Bastian, Colombo, Alessio, Zeitschel, Ulrike, Ellwart, Joachim W, Kremmer, Elisabeth, Roßner, Steffen, Lichtenthaler, Stefan F·2010·The EMBO Journal

DOI 10.1038/emboj.2010.167

Cited by (624)

Items 201–300 of 624

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15
Lisa Seipold, Hermann C. Altmeppen, Tomáš Koudelka, Andreas Tholey, Petr Kašpárek, Radislav Sedláček, Michaela Schweizer, Julia Bär, Marina Mikhaylova, Markus Glatzel et al. · 2018 · Cellular and Molecular Life Sciences
The Diverse Roles of TIMP-3: Insights into Degenerative Diseases of the Senescent Retina and Brain
Jennifer M. Dewing, Roxana Octavia Carare, Andrew John Lotery, J. Arjuna Ratnayaka · 2019 · Cells
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers
Heledd Jarosz-Griffiths, Nicola J. Corbett, Helen A. Rowland, Kate Fisher, Alys C. Jones, Jennifer Baron, Gareth J. Howell, Sally A. Cowley, Satyan Chintawar, M. Zameel Cader et al. · 2019 · Journal of Biological Chemistry
Activation of the α-Secretase Processing of AβPP as a Therapeutic Approach in Alzheimer's Disease
Bruno Vincent, Piyarat Govitrapong · 2011 · Journal of Alzheimer s Disease
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling
Neha Kabra Woods, Jose Trevino, Domenico Coppola, Srikumar Chellappan, Shengyu Yang, Jaya Padmanabhan · 2015 · Oncotarget
Regulation of the α-secretase ADAM10 at transcriptional, translational and post-translational levels
Bruno Vincent · 2016 · Brain Research Bulletin
Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding
Benjamin Shackleton, Fiona Crawford, Corbin J. Bachmeier · 2016 · Fluids and Barriers of the CNS
Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones
Nneka E. Mbah, Jean H. Overmeyer, William A. Maltese · 2016 · Cell Biology and Toxicology
Inhibition of Amyloid Precursor Protein Processing Enhances Gemcitabine-mediated Cytotoxicity in Pancreatic Cancer Cells
Neha Kabra Woods, Jaya Padmanabhan · 2013 · Journal of Biological Chemistry
The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance
Bai-Ping Wang, Hongmei Li, Sena Mutlu, D. Bowser, M. Moore, Meng C. Wang, Hui Zheng · 2017 · eNeuro
Amyloid precursor protein‐mediated mitochondrial regulation and Alzheimer's disease
Lopez Sanchez, M Isabel G, van Wijngaarden, Peter, Trounce, Ian A · 2019 · British Journal of Pharmacology
Neuropathology of the Alzheimer's continuum: an update
K. A. Jellinger · 2020 · Free Neuropathology
P2Y receptors in Alzheimer's disease
Laurie Erb, Cao Chen, Deepa Ajit, Gary A. Weisman · 2014 · Biology of the Cell
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport
Martin Steuble, Tu‐My Diep, Philipp Schätzle, Alexander Ludwig, Mitsuo Tagaya, Beat Kunz, Peter Sonderegger · 2012 · Biology Open
State of Play in Alzheimer’s Disease Genetics
Jin-Bao Zhu, Chen‐Chen Tan, Lan Tan, Jin‐Tai Yu · 2017 · Journal of Alzheimer s Disease
The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation
Tobias Brummer, Martina Pigoni, Armando Rossello, Huanhuan Wang, Peter John Noy, Michael G. Tomlinson, Carl Blobel, Stefan F. Lichtenthaler · 2018 · The FASEB Journal
Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease
Marcus O.W. Grimm, Viola J. Haupenthal, Tatjana L. Rothhaar, Valerie C. Zimmer, Sven Grösgen, Benjamin Hundsdörfer, Johannes Lehmann, Heike S. Grimm, Tobias Hartmann · 2013 · International Journal of Molecular Sciences
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formation
María Pagnon de la Vega, Vilmantas Giedraitis, Wojciech Michno, Lena Kilander, Gökhan Güner, Mara Zielinski, Malin Löwenmark, RoseMarie Brundin, Torsten Danfors, Linda Söderberg et al. · 2021 · Science Translational Medicine
Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
Nasim Rezaee, Warnakulasuriya Mary Ann Dipika Binosha Fernando, Eugene Hone, Hamid Reza Sohrabi, Stuart Keith Johnson, Stuart T. Gunzburg, Ralph Nigel Martins · 2021 · Frontiers in Aging Neuroscience
ADAM10 controls the differentiation of the coronary arterial endothelium
Gregory Farber, Matthew Parks, Nicole Lustgarten Guahmich, Yi Zhang, Sébastien Monette, Scott C. Blanchard, Annarita Di Lorenzo, Carl Blobel · 2018 · Angiogenesis
Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer’s Disease
Karissa Barthelson, Morgan Newman, Michael T. Lardelli · 2020 · Journal of Alzheimer s Disease Reports
ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε
Moustapha Cissé, Ursula Braun, Michael Leitges, Abraham Fisher, Gilles Pagès, Frédéric Checler, Bruno Vincent · 2011 · Molecular and Cellular Neuroscience
Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.
F. Gil-Bea, G. Gereñu, B. Aisa, L. Kirazov, R. Schliebs, M. Ramírez · 2012 · Neurobiology of Disease
Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease
George Anthony Pantelopulos, Conor B. Abraham, John E. Straub · 2024 · Annual Review of Biophysics
Soluble amyloid precursor proteins and secretases as Alzheimer's disease biomarkers
Robert Perneczky, Panagiotis Alexopoulos, Alexander Kurz · 2013 · Trends in Molecular Medicine
The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding
Thorsten Maretzky, Astrid Evers, Sylvain M. Le Gall, Rolake O. Alabi, Nancy Speck, Karina Reiß, Carl Blobel · 2015 · Journal of Biological Chemistry
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology
Bruce X. W. Wong, Ya Hui Hung, Ashley Ian Bush, James A. Duce · 2014 · Frontiers in Aging Neuroscience
A Disintegrin and Metalloproteases (ADAMs) in Cardiovascular, Metabolic and Inflammatory Diseases: Aspects for Theranostic Approaches
Emiel P. C. van der Vorst, Christian Weber, Marjo M. P. C. Donners · 2018 · Thrombosis and Haemostasis
GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein
Nakamura, Mai, Li, Yuhan, Choi, Bo-Ran, Matas-Rico, Elisa, Troncoso, Juan, Takahashi, Chiaki, Sockanathan, Shanthini · 2021 · Science Translational Medicine
Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence
Mohammad Rafi Khezri, Mehdi Mohebalizadeh, Morteza Ghasemnejad‐Berenji · 2023 · Cell Communication and Signaling
A Brief History of Tumor Necrosis Factor α – converting Enzyme: An Overview of Ectodomain Shedding
Keisuke Horiuchi · 2013 · The Keio Journal of Medicine
β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
Erik Portelius, Robert A. Dean, Ulf Andréasson, Niklas Mattsson, Anni Westerlund, Maria Olsson, Ronald Bradley Demattos, Margaret M. Racke, Henrik Zetterberg, Patrick C. May et al. · 2014 · Alzheimer s Research & Therapy
Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer’s disease
Brijesh Kumar Singh, Naman Vatsa, Vipendra Kumar, Shashi Shekhar, Ankit Sharma, Nihar Ranjan Jana · 2017 · Human Molecular Genetics
Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA
Simone Eggert, Adriana Carolina Gonzalez, Carolin Thomas, Sandra Schilling, S. M. Schwarz, Christian Tischer, Vojtěch Adam, Paul Strecker, Vanessa Schmidt, Thomas E. Willnow et al. · 2017 · Cellular and Molecular Life Sciences
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer’s Disease
Xueshen Qian, Shuang Zhang, Lian Duan, Fengchun Yang, Kun Zhang, Fuhua Yan, Song Ge · 2021 · Journal of Alzheimer s Disease
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1
Yon Ju Ji, Yoo‐Seok Hwang, Kathleen Mood, Hee-Jun Cho, Hyun‐Shik Lee, Emily F. Winterbottom, Hélène Cousin, Ira Owen Daar · 2014 · Nature Communications
Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10
Stefano Musardo, Elena E. Marcello · 2017 · European Journal of Pharmacology
Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.
Paumier, Jean-Michel, Py, Nathalie A., García-González, Laura, Bernard, Anne, Stephan, Delphine, Louis, Laurence, Checler, Frédéric, Khrestchatisky, Michel, Baranger, Kévin, Rivera, Santiago · 2019 · The FASEB Journal
Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
Fernando G. Ortega, Jonathan Stott, Sandra A. G. Visser, Claus Bendtsen · 2012 · Journal of Biological Chemistry
Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells
Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan‐You Wang · 2018 · Frontiers in Aging Neuroscience
Bryostatin-1: a promising compound for neurological disorders
Zhen Tian, Xin-tong Lu, Xun Jiang, Jiao Tian · 2023 · Frontiers in Pharmacology
Increased Plasma TACE Activity in Subjects with Mild Cognitive Impairment and Patients with Alzheimer's Disease
Qiying Sun, Harald Juergen Hampel, Kaj Blennow, Simone Lista, Allan I. Levey, Beisha Tang, Rena Li, Yong Shen · 2014 · Journal of Alzheimer s Disease
Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters
T. Toneff, Lydiane Funkelstein, Charles Mosier, Armen Abagyan, Michael Ziegler, V. Hook · 2013 · Peptides
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding
Linda Schauenburg, Filip Liebsch, Murat Eravci, Magnus Mayer, Christoph Weise, Gerhard Multhaup · 2018 · Scientific Reports
Early Stage Glycosylation Biomarkers in Alzheimer’s Disease
Patricia Regan, Paula L. McClean, Thomas J. Smyth, Margaret Doherty · 2019 · Medicines
The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders
Aurel George Mohan, Bogdan Calenic, Nicu Adrian Ghiurau, Roxana Duncea-Borca, Alexandra-Elena Constantinescu, Ileana Constantinescu · 2023 · Cells
Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease
Taisuke Tomita · 2017 · Advances in Biological Regulation
Role of Rab GTPases in Alzheimer’s Disease
Xian Zhang, Timothy Y. Huang, Joel Yancey, Hong Luo, Yun‐wu Zhang · 2018 · ACS Chemical Neuroscience
Protective Role of Capsaicin in Neurological Disorders: An Overview
Sakshi Tyagi, Nikhila Shekhar, Ajit Kumar Thakur · 2022 · Neurochemical Research
The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease
Stefano Musardo, S. Therin, Silvia Pelucchi, Laura D’Andrea, Ramona Stringhi, Ana Ribeiro, Annalisa Manca, Claudia Balducci, Jessica Pagano, Carlo Sala et al. · 2022 · Molecular Therapy
Cholesterol‐induced astrocyte activation is associated with increased amyloid precursor protein expression and processing
Evangelina Ávila-Muñoz, Clorinda Arias · 2015 · Glia
Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease
Mallory Gough, Catherine A. Parr-Sturgess, Edward T. Parkin · 2010 · Biochemistry Research International
APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets
Sònia Sirisi, Érika Sánchez‐Aced, Olivia Belbin, Alberto Lleó · 2024 · Alzheimer s Research & Therapy
Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging
Florian Schuck, D. Wolf, A. Fellgiebel, K. Endres · 2016 · Journal of Alzheimer's Disease
Current and Emerging Pharmacological Targets for the Treatment of Alzheimer’s Disease
Ahmed Morsy, Paul C. Trippier · 2019 · Journal of Alzheimer s Disease
Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking
Timo Sarajärvi, Jussi T. Tuusa, Annakaisa Haapasalo, Jarkko J. Lackman, Raija T. Sormunen, Seppo Helisalmi, Johannes T. Roehr, Antonio Parrado, Petra M. Mäkinen, Lars Bertram et al. · 2011 · Molecular and Cellular Biology
Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer’s Disease
Magdalena Korsak, Tatiana Kozyreva · 2015 · Advances in experimental medicine and biology
ADAM10 Prodomain Mutations Cause Late-Onset Alzheimer’s Disease: Not Just the Latest FAD
Vassar, Robert · 2013 · Neuron
Loss of PAFAH1B2 Reduces Amyloid-β Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments
Richard M. Page, Anna Münch, Thomas L. Horn, Peer‐Hendrik Kuhn, Alessio Vittorio Colombo, Orly Reiner, Michael Boutros, Harald Steiner, Stefan F. Lichtenthaler, Christian Haass · 2012 · Journal of Neuroscience
AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production
Sarah E. Hoey, Federica Buonocore, Carla J. Cox, Victoria J. Hammond, Michael S. Perkinton, Robert J. Williams · 2013 · PLoS ONE
Advances with RNA interference in Alzheimer’s disease research
Weien Yuan, Shun Chen, Xuemei Ge, Yinghui Chen, Nan Lu, Zhenguo Liu · 2013 · Drug Design Development and Therapy
Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells
Daniel Janitschke, Christopher Nelke, Anna Andrea Lauer, Liesa Regner-Nelke, Jakob Winkler, Andrea Thiel, Heike S. Grimm, Tobias Hartmann, Marcus O.W. Grimm · 2019 · Biomolecules
Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model
Mikiko Ohno, Yoshinori Hiraoka, Stefan F. Lichtenthaler, Kiyoto Nishi, Sayaka Saijo, Tatsuhiko Matsuoka, Hidekazu Tomimoto, Wataru Araki, Ryōsuke Takahashi, Toru Kita et al. · 2013 · Neurobiology of Aging
BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
Kim, WonHee, Ma, Liang, Lomoio, Selene, Willen, Rachel, Lombardo, Sylvia, Dong, Jinghui, Haydon, Philip G., Tesco, Giuseppina · 2018 · Molecular Neurodegeneration
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD
Mareike Czuppa, Ashutosh Dhingra, Qihui Zhou, Carina Schludi, Laura E. König, Elisabeth Scharf, Daniel Farny, Anupriya Dalmia, Joachim Täger, Melissa Castillo-Lizardo et al. · 2022 · Cell Reports
A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population
Binbin Wang, Suying Bao, Zhigang Zhang, Xueya Zhou, Jing Wang, Yanhui Fan, Yan Zhang, Yan Li, Luhua Chen, Yizhen Jia et al. · 2018 · Neurobiology of Aging
Isoform-specific cleavage of neuroligin-3 reduces synapse strength
Michael A. Bemben, Thien Nguyen, Yan Li, Tongguang Wang, Roger A. Nicoll, Katherine W. Roche · 2018 · Molecular Psychiatry
DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease
Harriet M. Jackson, Kristen D. Onos, Keating W. Pepper, Leah C. Graham, Ellen C. Akeson, Candice Byers, Laura G. Reinholdt, Wayne N. Frankel, Gareth R. Howell · 2015 · PLoS ONE
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein
Lisa Seipold, Markus Daμμe, Johannes Prox, Björn Rabe, Petr Kašpárek, Radislav Sedláček, Hermann C. Altmeppen, Michael Willem, Barry Boland, Markus Glatzel et al. · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
Bor Luen Tang · 2019 · Cells
Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review
David Vogrinc, Katja Goričar, Vita Dolžan · 2021 · Frontiers in Aging Neuroscience
Correlation Between Mini-Mental State Examination and Platelet ADAM10 Expression in Alzheimer's Disease
Patrícia Regina Manzine, Elizabeth Joan Barham, Francisco de Assis Carvalho do Vale · 2013 · Journal of Alzheimer s Disease
Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease
Patrícia Regina Manzine, Elizabeth Joan Barham, Francisco Assis Carvalho Vale, Heloísa Sobreiro Selistre-de-Araújo, Sofía Cristina Iost Pavarini, Márcia R. Cominetti · 2013 · International Journal of Geriatric Psychiatry
Family C G-Protein-Coupled Receptors in Alzheimer’s Disease and Therapeutic Implications
Ilaria Dal Prà, Ubaldo Armato, Anna Chiarini · 2019 · Frontiers in Pharmacology
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage
Rielana Wichert, Franka Scharfenberg, Cynthia Colmorgen, Tomáš Koudelka, Jeanette Schwarz, Sebastian Wetzel, Barbara Aleksandra Potempa, Jan Potempa, Jörg Walter Bartsch, Irit Sagi et al. · 2019 · The FASEB Journal
The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17
Yuanpeng Zheng, Tessa A. Verhoeff, Paula Perez‐Pardo, Johan Garssen, Aletta D. Kraneveld · 2020 · International Journal of Molecular Sciences
A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer’s Disease
Paloma Bermejo‐Bescós, Karim Jiménez‐Aliaga, Juana Benedı́, Sagrario Martín‐Aragón · 2023 · International Journal of Molecular Sciences
Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Linghui Zeng, Jun Tan · 2023 · Aging and Disease
Trafficking in neurons: Searching for new targets for Alzheimer's disease future therapies
Stefano Musardo, Claudia Saraceno, Silvia Pelucchi, Elena E. Marcello · 2013 · European Journal of Pharmacology
Proteomic Substrate Identification for Membrane Proteases in the Brain
Stephan A. Müller, Simone Dario Scilabra, Stefan F. Lichtenthaler · 2016 · Frontiers in Molecular Neuroscience
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation
Xinjian Zhu, Xiaolin Li, Mengyi Zhu, Kangni Xu, Li Yang, Bing Han, Rongrong Huang, Aifeng Zhang, Honghong Yao · 2018 · Journal of Neuroinflammation
Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer’s Disease Development
Anatoly S. Urban, Konstantin V. Pavlov, A. V. Kamynina, Ivan S. Okhrimenko, Alexander S. Arseniev, Eduard Valeryevich Bocharov · 2021 · Molecules
Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission
Anna Kreis, Jana Desloovere, Núria Suelves, Nathalie Pierrot, Xavier Yerna, Farah Issa, Olivier Schakman, Roberta Gualdani, Marie de Clippele, Nicolas Tajeddine et al. · 2021 · Scientific Reports
The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10
Yuanpeng Zheng, Naika Prince, Lucía N. Peralta Marzal, Sabbir Ahmed, Johan Garssen, Paula Perez‐Pardo, Aletta D. Kraneveld · 2022 · International Journal of Molecular Sciences
RNA binding proteins in senescence: A potential common linker for age-related diseases?
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Annalisa Barbieri, Lorenzo Rossi, Giovanni Ricevuti, Ciro Esposito, Salvatore Chirumbolo, Nicoletta Marchesi, Alessia Pascale · 2023 · Ageing Research Reviews
ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects
Patrícia Regina Manzine, Elena Marcello, Barbara Borroni et al. · 2015 · Biomarkers
The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration
Francesc Xavier Guix · 2019 · Journal of Neuroscience Research
Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats
Juan Huang, Nanqu Huang, Minghui Zhang, Jing Nie, Yun‐Yan Xu, Qin Wu, Jingshan Shi · 2019 · PeerJ
Advances in Genetics and Epigenetic Alterations in Alzheimer’s Disease: A Notion for Therapeutic Treatment
Rubén Rabaneda‐Bueno, Beatriz Mena‐Montes, Sara Torres‐Castro, Norma Torres‐Carrillo, Nora Magdalena Torres-Carrillo · 2021 · Genes
A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome
Leanne K. Hein, Pirjo M. Apaja, Kathryn J. Hattersley, Randall Grose, Jianling Xie, Christopher G. Proud, Timothy J. Sargeant · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
Simone Dario Scilabra, Martina Pigoni, Veronica M. Pravatà · 2018 · Scientific Reports
Alzheimer’s Disease Genetics: Review of Novel Loci Associated with Disease
Miguel Tábuas‐Pereira, Isabel J. Santana, Rita João Guerreiro, José Brás · 2020 · Current Genetic Medicine Reports
Is the p3 Peptide (Aβ17-40, Aβ17-42) Relevant to the Pathology of Alzheimer’s Disease?1
Ariel J. Kuhn, Jevgenij A. Raskatov · 2020 · Journal of Alzheimer s Disease
Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system
Gemma Llufriu-Dabén, Alex Carreté, Elena Chierto, Jo Mailleux, Emeline Camand, Anne Simon, Tim Vanmierlo, Christiane Rose, Bernadette Allinquant, Jerome J. A. Hendriks et al. · 2017 · Neurobiology of Disease
Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling
Zhuo Min, Ying Tang, Xiaotong Hu, Binglin Zhu, Yuanlin Ma, Jing‐Si Zha, Xiaojuan Deng, Zhen Yan, Guojun Chen · 2018 · Frontiers in Molecular Neuroscience
The Glucose Metabolic Pathway as A Potential Target for Therapeutics: Crucial Role of Glycosylation in Alzheimer’s Disease
Vidyasagar Naik Bukke, Rosanna Villani, Archana Moola, Agata Wawrzyniak, Krzysztof Balawender, Stanisław Orkisz, Luca Ferraro, Gaetano Serviddio, Tommaso Cassano · 2020 · International Journal of Molecular Sciences
The C99 domain of the amyloid precursor protein resides in the disordered membrane phase
Ricardo F. Capone, Ajit Tiwari, Arina Hadziselimovic, Yelena B. Peskova, James M. Hutchison, Charles R. Sanders, Anne K. Kenworthy · 2021 · Journal of Biological Chemistry
Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33
Bastian Dislich, Manuel E. Than, Stefan F. Lichtenthaler · 2010 · Biochemical Journal
Identification of a novel amyloid precursor protein processing pathway that generates secreted N‐terminal fragments
Laura J. Vella, Roberto Cappai · 2012 · The FASEB Journal
A short perspective on the long road to effective treatments for Alzheimer's disease
David S. Reynolds · 2019 · British Journal of Pharmacology