The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition: FGF-2 enhances TGF-β-induced EMT
Open accessAbstract
The epithelial–mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair, and cancer progression in adult tissues. Here, we demonstrate that transforming growth factor (TGF)‐β induced EMT and that long‐term exposure to TGF‐β elicited the epithelial–myofibroblastic transition (EMyoT) by inactivating the MEK‐Erk pathway. During the EMT process, TGF‐β induced isoform switching of fibroblast growth factor (FGF) receptors, causing the cells to become sensitive to FGF‐2. Addition of FGF‐2 to TGF‐β‐treated cells perturbed EMyoT by reactivating the MEK‐Erk pathway and subsequently enhanced EMT through the formation of MEK‐Erk‐dependent complexes of the transcription factor δEF1/ZEB1 with the transcriptional corepressor CtBP1. Consequently, normal epithelial cells that have undergone EMT as a result of combined TGF‐β and FGF‐2 stimulation promoted the invasion of cancer cells. Thus, TGF‐β and FGF‐2 may cooperate with each other and may regulate EMT of various kinds of cells in cancer microenvironment during cancer progression. Both TGF‐β and FGF signalling regulate the epithelial–mesenchymal transition. Here, TGF‐β is found to promote myofibroblast differentiation, while concomitant FGF pathway activation instead drives cells towards an invasive mesenchymal fate.
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Cites
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299 · cited 1×
“Recent studies have proposed that EMT can be classified into three subtypes based on the biological context (Thiery and Sleeman, 2006; Kalluri and Weinberg, 2009; Kalluri, 2009; Zeisberg and Neilson, 2009).”
Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589 · cited 1×
“Cancer cell invasion was re- cently classified into two categories, so-called ‘collective cancer cell invasion’ and ‘fibroblast-led collective invasion’ (Gaggioli et al, 2007).”
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Cited by
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Self-citationTGF-β signaling and epithelial–mesenchymal transition in cancer progression
Katsuno, Y., Lamouille, S., & Derynck, R. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835b6371 · Cited by 786
The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
Nieto, M. A. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154036 · Cited by 720
Metadata
- Authors
- Shirakihara, T., Horiguchi, K., Miyazawa, K., Ehata, S., Shibata, T., Morita, I., Miyazono, K., & Saitoh, M.
- Venue
- The EMBO Journal
- Published
- 2011-01-11
- Volume
- 30
- Issue
- 4
- Pages
- 783-795
- ISSN
- 0261-4189 (ISSN-L)
- OpenAlex
- W1678482413
- Cited by
- 227
- References
- 6
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shirakihara, T., Horiguchi, K., Miyazawa, K., Ehata, S., Shibata, T., Morita, I., Miyazono, K., & Saitoh, M. (2011). TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition: FGF-2 enhances TGF-β-induced EMT. The EMBO Journal. https://doi.org/10.1038/emboj.2010.351
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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