Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

Drosten, Matthias, Dhawahir, Alma, Sum, Eleanor Y M, Urosevic, Jelena, Lechuga, Carmen G, Esteban, Luis M, Castellano, Esther, Guerra, Carmen, Santos, Eugenio, Barbacid, Mariano·2010·The EMBO Journal
DOI 10.1038/emboj.2010.7

Cited by (348)

Items 101–200 of 348

  1. Constitutive K - Ras G12D Activation of ERK2 Specifically Regulates 3D Invasion of Human Pancreatic Cancer Cells via MMP-1
    Gregory P. Botta, Mauricio J. Reginato, Maximilian Reichert, Anil K. Rustgi, Peter I. Lelkes · 2011 · Molecular Cancer Research
  2. Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth
    Bettina Reichenbach, Johanna Classon, Tomomi Aida, Kohichi Tanaka, Maria Genander, Christian Göritz · 2018 · The EMBO Journal
  3. Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
    Ricciuti, Biagio, Son, Jieun, Okoro, Jeffrey J., Mira, Alessia, Patrucco, Enrico, Eum, Yoonji, Wang, Xinan, Paranal, Raymond, Wang, Haiyun, Lin, Mika et al. · 2022 · Clinical Cancer Research
  4. Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation
    Ruth Nussinov, Chung‐Jung Tsai, Serena Muratcioğlu, Hyunbum Jang, Attila Gürsoy, Özlem Keskin · 2015 · Expert Review of Proteomics
  5. SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status
    Ha Yong Song, Marco Biancucci, Hong-Jun Kang, Carol O'Callaghan, Seong‐Hoon Park, Daniel R. Principe, Haiyan Jiang, Yufan Yan, K.J.F. Satchell, Kirtee Raparia et al. · 2016 · Oncotarget
  6. Substrate stiffness regulates arterial-venous differentiation of endothelial progenitor cells via the Ras/Mek pathway
    Changyue Xue, Tao Zhang, Xueping Xie, Qi Zhang, Shu Zhang, Bofeng Zhu, Yunfeng Lin, Xiaoxiao Cai · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  7. Small molecular inhibitors for KRAS-mutant cancers
    Xuan Wu, Wenping Song, Cheng Cheng, Ziyang Liu, Xiang Li, Yu Cui, Yao Gao, Li Ding · 2023 · Frontiers in Immunology
  8. Analysis of Gene Expression in Bladder Cancer: Possible Involvement of Mitosis and Complement and Coagulation Cascades Signaling Pathway
    Ying Liu, Shenghua Xiong, Shiying Liu, Jie Chen, Hao Yang, Gang Liu, Gengmi Li · 2019 · Journal of Computational Biology
  9. Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway
    Shuai Li, Tangming Peng, Xia Zhao, Marta Silva, Linlin Liu, Wenshu Zhou, Ligang Chen, Wenhua Zheng · 2021 · Redox Biology
  10. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice
    Bhairavi Tolani, Anna Celli, Yanmin Yao, Yong Zi Tan, Richard Doty Fetter, Christina R. Liem, Adam J. de Smith, Thamiya Vasanthakumar, Paola Bisignano, Adam D. Cotton et al. · 2022 · Nature Biotechnology
  11. Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex
    Wang Peng, Sun Zhi-yin, Qi Zhang, Sui-Qi Cheng, Shi‐Ke Wang, Xiaona Wang, Guotao Kuang, Xiaoxuan Su, Jia‐Heng Tan, Zhi‐Shu Huang et al. · 2018 · Journal of Medicinal Chemistry
  12. An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth
    Vania Vidimar, Greg L. Beilhartz, Minyoung Park, Marco Biancucci, Matthew B. Kieffer, David R. Gius, Roman A. Melnyk, K.J.F. Satchell · 2020 · Proceedings of the National Academy of Sciences
  13. Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling
    Lauren M. Adams, Caroline J. DeHart, Bryon Drown, Lissa C. Anderson, William Bocik, Emily S. Boja, Tara Hiltke, Christopher L. Hendrickson, Henry Rodriguez, Michael A. Caldwell et al. · 2022 · Journal of Biological Chemistry
  14. Ras signals principally via Erk in G1 but cooperates with PI3K/Akt for Cyclin D induction and S-phase entry
    Ledia Vasjari, Stephanie Bresan, Christoph U. Biskup, Govind M. Pai, Ignacio Rubio · 2018 · Cell Cycle
  15. Intrinsic GTPase activity of K-RAS monitored by native mass spectrometry
    Moghadamchargari, Zahra, Huddleston, Jamison, Shirzadeh, Mehdi, Zheng, Xueyun, Clemmer, David E., M. Raushel, Frank, Russell, David H., Laganowsky, Arthur · 2019 · Biochemistry
  16. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity
    Pau Castel, Srisathiyanarayanan Dharmaiah, Matthew J. Sale, Simon A. J. Messing, Gabrielle A. Rizzuto, Antonio Cuevas-Navarro, Alice Shasha Cheng, Michael J. Trnka, Anatoly Urisman, Dominic Esposito et al. · 2021 · Proceedings of the National Academy of Sciences
  17. The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer
    Sunny Guin, Dan Theodorescu · 2015 · Acta Pharmacologica Sinica
  18. The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
    William J. McDaid, L. Wilson, Helen Adderley, A. Martinez-Lopez, Martin J. Baker, J. Searle, L. H. GINN, Timothy Budden, Mihaela D. Aldea, Arianna Marinello et al. · 2024 · Molecular Cancer
  19. H-Ras Distribution and Signaling in Plasma Membrane Microdomains Are Regulated by Acylation and Deacylation Events
    Lorena Agudo‐Ibáñez, Ana Herrero, Mariano Barbacid, Piero Crespo · 2015 · Molecular and Cellular Biology
  20. An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors
    Martín Indarte, Roisin Puentes, Marco Maruggi, Nathan T. Ihle, Geoffrey V. Grandjean, Michael J. Scott, Zamal Ahmed, Emmanuelle J. Meuillet, Shuxing Zhang, Robert Lemos et al. · 2019 · Cancer Research
  21. The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways
    Romain Vasseur, Nicolas Skrypek, Bélinda Duchêne, Florence Renaud, Daniel Martínez‐Maqueda, Audrey Vincent, Nicole Porchet, Isabelle VAN SEUNINGEN, Nicolas Jonckheere · 2015 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  22. Virtual screening for small-molecule pathway regulators by image-profile matching
    Mohammad Hossein Rohban, Ashley M. Fuller, Ceryl Tan, Jonathan T. Goldstein, Deepsing Syangtan, Amos Gutnick, Ann Devine, Madhura P. Nijsure, Megan Rigby, Joshua R. Sacher et al. · 2022 · Cell Systems
  23. Feedback activation of neurofibromin terminates growth factor-induced Ras activation
    Anne Hennig, Robby Markwart, Katharina Wolff, Katja Schubert, Yan Cui, Ian A. Prior, Manuel A. Esparza-Franco, Graham Ladds, Ignacio Rubio · 2016 · Cell Communication and Signaling
  24. Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression
    Michelle Cicchini, Elizabeth L. Buza, Kyra M. Sagal, A. Andrea Gudiel, Amy C. Durham, David M. Feldser · 2017 · Cell Reports
  25. Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras
    Danielle E. Frodyma, Beth K. Neilsen, Diane L. Costanzo-Garvey, Kurt W. Fisher, Robert E. Lewis · 2017 · F1000Research
  26. Molecular Mechanism of Phosphorylation-Mediated Impacts on the Conformation Dynamics of GTP-Bound KRAS Probed by GaMD Trajectory-Based Deep Learning
    Jianzhong Chen, Jian Wang, Wanchun Yang, Lu Zhao, Juan Zhao, Guodong Hu · 2024 · Molecules
  27. Melanoma Mutagenesis and Aberrant Cell Signaling
    Danielle M. Bello, Charlotte Eielson Ariyan, Richard D. Carvajal · 2013 · Cancer Control
  28. RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation
    Berta Casar, Andrew P. Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón‐Bolea, Luis Francisco Lorenzo‐Martín, Irene Barinaga-Rementeria Ramirez, Jorge Barriuso, Vincenzo Cappitelli, Daniel J. Donoghue et al. · 2018 · Nature Communications
  29. KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors
    Paniagua, Guillem, Jacob, Harrys K.C., Brehey, Oksana, García‐Alonso, Sara, Lechuga, Carmen G., Pons, Tirso, Musteanu, Monica, Guerra, Carmen, Drosten, Matthias, Barbacid, Mariano · 2022 · Molecular Oncology
  30. The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development
    Romain M. Larive, Antonio Abad, Clara Moyano Cardaba, Teresa Hernández, Marta Cañamero, Enrique de Álava, Eugenio Santos, Balbino Alarcón, Xosé R. Bustelo · 2012 · Molecular Biology of the Cell
  31. Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
    Rósula García‐Navas, Pilar Liceras-Boillos, Carmela Gómez, Fernando C. Baltanás, Nuria Calzada, Cristina Nuevo‐Tapioles, Jose Manuel Cuezva, Eugenio Santos · 2021 · Oncogene
  32. Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis
    Pilar Liceras-Boillos, David Jimeno, Rósula García‐Navas, Luis Francisco Lorenzo‐Martín, Mauricio Menacho-Márquez, Carmen Segrelles, Carmela Gómez, Nuria Calzada, Rocío Fuentes‐Mateos, Jesús María Paramio et al. · 2018 · Molecular and Cellular Biology
  33. Mechanistic Insights into the Long-range Allosteric Regulation of KRAS Via Neurofibromatosis Type 1 (NF1) Scaffold Upon SPRED1 Loading
    Min-Yu Li, Yuanhao Wang, Jigang Fan, Haiming Zhuang, Yaqin Liu, Dong Ji, Shaoyong Lu · 2022 · Journal of Molecular Biology
  34. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
    Sisi Chen, Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lü, Simon J. Hogg, Eric Wang, Salima Benbarche, Katherine L. B. Knorr, Won Jun Kim, Robert F. Stanley et al. · 2022 · Cancer Discovery
  35. Combination Therapies to Inhibit the RAF/MEK/ERK Pathway in Melanoma: We are not Done Yet
    Grant A. McArthur · 2015 · Frontiers in Oncology
  36. Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation
    Duan Ni, Kun Song, Jian Zhang, Shaoyong Lu · 2017 · International Journal of Molecular Sciences
  37. Inhibition of Nonfunctional Ras
    Ruth Nussinov, Hyunbum Jang, Attila Gürsoy, Özlem Keskin, Vadim Gaponenko · 2021 · Cell chemical biology
  38. Bioconjugation Strategies for Revealing the Roles of Lipids in Living Cells
    Caroline H. Knittel, Neal K. Devaraj · 2022 · Accounts of Chemical Research
  39. RalA and RalB Proteins Are Ubiquitinated GTPases, and Ubiquitinated RalA Increases Lipid Raft Exposure at the Plasma Membrane
    Neyraud, Vincent, Aushev, Vasily N., Hatzoglou, Anastassia, Meunier, Brigitte, Cascone, Ilaria, Camonis, Jacques · 2012 · Journal of Biological Chemistry
  40. Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior
    Debanjan Goswami, De Chen, Yue Yang, Prabhakar R. Gudla, John Columbus, Karen M. Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell et al. · 2020 · eLife
  41. Polystyrene nanoplastics decrease nutrient accumulation, disturb sex hormones, and inhibit reproductive development in juvenile Macrobrachium nipponense
    Yiming Li, Yucong Ye, Na Rihan, Qichen Jiang, Xingguo Liu, Yunlong Zhao, Xuan Che · 2023 · The Science of The Total Environment
  42. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
    Antonio Cuevas-Navarro, Morgan E. Wagner, Richard Van, Monalisa Swain, Stephanie Mo, John Columbus, Madeline R. Allison, Alice Shasha Cheng, Simon A. J. Messing, Thomas J. Turbyville et al. · 2023 · Science Advances
  43. A Nonconserved Histidine Residue on KRAS Drives Paralog Selectivity of the KRASG12D Inhibitor MRTX1133
    Miles A. Keats, John J.W. Han, Yeon‐Hwa Lee, Chih-Shia Lee, Ji Luo · 2023 · Cancer Research
  44. Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling
    Shu-Ping Song, Anne Hennig, Katja Schubert, Robby Markwart, Philipp Schmidt, Ian A. Prior, Frank-Dietmar Böhmer, Ignacio Rubio · 2013 · Biochemical Journal
  45. Leishmania donovani infection differentially regulates small G‐proteins
    Atahar Husein, Azfar Jamal, Mohammad Z. Ahmed, Mohammad Arish, Rahat Azhar Ali, Shams S. M. Tabrez, Fayyaz Rasool, Abdur Rub · 2018 · Journal of Cellular Biochemistry
  46. Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS
    Antonio Ward, Adam B. Keeton, Xi Chen, Tyler Ernest Mattox, Alexander B. Coley, Yulia Y. Maxuitenko, Donald J. Buchsbaum, Troy D. Randall, Gang Zhou, Gary Anthony Piazza · 2020 · MedComm
  47. A CRISPR-Cas9 repressor for epigenetic silencing of KRAS
    Jingwen Liu, Meiyan Sun, Kwang Bog Cho, Xiang Gao, Bin Guo · 2020 · Pharmacological Research
  48. Exploring CRD mobility during RAS/RAF engagement at the membrane
    Kien Nguyen, César A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale, Timothy S. Travers, Timothy H. Tran, Albert H. Chan, Harsh Bhatia et al. · 2022 · Biophysical Journal
  49. Computer-Aided Drug Design Boosts RAS Inhibitor Discovery
    Ge Wang, Yuhao Bai, Jiarui Cui, Zirui Zong, Yuan Gao, Zhen Zheng · 2022 · Molecules
  50. Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification
    Antonio Tedeschi, Fiorella Schischlik, Francesca Rocchetti, Johannes Popow, Florian Ebner, Daniel Gerlach, Antonia Geyer, Valeria Santoro, Andrew S. Boghossian, Matthew G. Rees et al. · 2024 · Molecular Cancer Therapeutics
  51. Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction
    David Durrant, Emily A. Smith, Ekaterina I. Goncharova, Nirmala D. Sharma, Patrick Alexander, Andrew G. Stephen, Curtis J. Henrich, Deborah K. Morrison · 2021 · Molecular Cancer Therapeutics
  52. Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
    Lo Lai, Nicole D. Fer, William E. Burgan, Vanessa E. Wall, Bingfang Xu, Daniel R. Soppet, Dominic Esposito, Dwight V. Nissley, Frank P. McCormick · 2022 · Proceedings of the National Academy of Sciences
  53. A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
    Isabel Fernández‐Pisonero, Laura Clavaín, Javier Robles‐Valero, Luis Francisco Lorenzo‐Martín, Rubén Caloto, Blanca Nieto, Carmen García-Macías, Clara L. Oeste, Manuel Sánchez‐Martín, Antonio Abad et al. · 2022 · Cell Reports
  54. The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
    Rodrigo Entrialgo‐Cadierno, Cristina Cueto‐Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Inés López et al. · 2023 · Molecular Cancer
  55. The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence
    Heike Helmbold, Umberto Galderisi, Wolfgang Bohn · 2011 · Journal of Cellular Physiology
  56. A treatment strategy for KRAS-driven tumors
    Mai, Trang T., Lito, Piro · 2018 · Nature Medicine
  57. Deconstructing ERK Signaling in Tumorigenesis
    Patricia G. Santamarı́a, Ángel R. Nebreda · 2010 · Molecular Cell
  58. Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
    Imran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, Joshua Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Ernest Ramsay Camp et al. · 2022 · Cell Reports
  59. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
    Wenjing Su, Radha Mukherjee, Rona D. Yaeger, Jieun Son, Jianing Xu, Na Na, Neilawattie Merna Timaul, Jaclyn Frances Hechtman, Viktoriya Paroder, Mika Lin et al. · 2022 · Molecular Cell
  60. Cancer in growth hormone excess and growth hormone deficit
    Jaime Guevara‐Aguirre, Gabriela Peña, William Acosta, Gabriel Pazmiño, Jannette Saavedra, Lina Soto, Daniela Lescano, Alexandra Guevara, Antonio W. D. Gavilanes · 2023 · Endocrine Related Cancer
  61. Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling
    Annette S. Little, Kathryn Balmanno, Matthew J. Sale, Paul D. Smith, Simon J. Cook · 2012 · Biochemical Society Transactions
  62. An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth
    Lingxiao Tan, Kwang-Jin Cho, Pratik Neupane, Robert J. Capon, John F. Hancock · 2018 · Journal of Biological Chemistry
  63. Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells
    Hsiang-Han Su, Chih-Mei Cheng, Yung‐Ning Yang, Yu‐Wei Chang, Chia‐Yang Li, Shin-Ting Wu, Chia‐Chi Lin, Hsin‐En Wu, Jau‐Ling Suen · 2023 · Mucosal Immunology
  64. MicroRNA 17-92 Cluster Mediates ETS1 and ETS2-Dependent RAS-Oncogenic Transformation
    Mohamed Kabbout, Duaa A. Dakhlallah, Sudarshana M. Sharma, Agnieszka Bronisz, Ruchika Srinivasan, Melissa G. Piper, Clay B. Marsh, Michael C. Ostrowski · 2014 · PLoS ONE
  65. Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints
    Patrick Alexander, Albert H. Chan, Dana Rabara, Monalisa Swain, Erik K. Larsen, Marcin D. Dyba, Oleg Chertov, Mariam Ashraf, Allison Champagne, Ken Yu Lin et al. · 2025 · Journal of Biological Chemistry
  66. ERK2-regulated TIMP1 Induces Hyperproliferation of K-RasG12D-Transformed Pancreatic Ductal Cells
    Gregory P. Botta, Maximilian Reichert, Mauricio J. Reginato, Steffen Heeg, Anil K. Rustgi, Peter I. Lelkes · 2013 · Neoplasia
  67. RAS and Hedgehog - partners in crime
    Matthias Lauth · 2011 · Frontiers in bioscience
  68. RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains
    Yong Zhou, Alemayehu Abebe Gorfe, John F. Hancock · 2021 · Frontiers in Molecular Biosciences
  69. Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice
    Rocío Fuentes‐Mateos, David Jimeno, Carmela Gómez, Nuria Calzada, Alberto Fernández‐Medarde, Eugenio Santos · 2019 · Cell Death and Disease
  70. The multifaceted role of aquaporins in physiological cell migration
    Ian M. Smith, Kimberly M. Stroka · 2023 · American Journal of Physiology-Cell Physiology
  71. Activated Ras Protein Accelerates Cell Cycle Progression to Perturb Madin-Darby Canine Kidney Cystogenesis
    Atsuro Sakurai, Michiyuki Matsuda, Etsuko Kiyokawa · 2012 · Journal of Biological Chemistry
  72. Progress of Immune Checkpoint Inhibitors Therapy for pMMR/MSS Metastatic Colorectal Cancer
    Fanjie Qu, Shuang Wu, WeiWei Yu · 2024 · OncoTargets and Therapy
  73. Transcriptomics unravels molecular players shaping dorsal lip hypertrophy in the vacuum cleaner cichlid, Gnathochromis permaxillaris
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  74. KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform
    Marina Salmón, Guillem Paniagua, Carmen G. Lechuga, Fernando Fernández-García, Eduardo Zarzuela, Ruth Álvarez, Mónica Musteanu, Carmen E. Guerra, Eduardo J. Caleiras, Javier Muñoz et al. · 2021 · Proceedings of the National Academy of Sciences
  75. Wnt4 inhibits cell motility induced by oncogenic Ras
    Marta De Menna, V D'Amato, Angelo Ferraro, Alfredo Fusco, Roberto Di Lauro, Corrado Garbi, Gabriella De Vita · 2012 · Oncogene
  76. Proteomic Analysis of Hepatic Tissue in Adult Female Zebrafish (Danio rerio) Exposed to Atrazine
    Yuanxiang Jin, Xiangxiang Zhang, Dezhao Lu, Zhengwei Fu · 2011 · Archives of Environmental Contamination and Toxicology
  77. Binding properties and biological characterization of new sugar-derived Ras ligands
    Elena Sacco, Sherwin J. Abraham, Alessandro Palmioli, Gaetana Damore, Anna Bargna, Elisa Mazzoleni, Vadim Gaponenko, Marco Vanoni, Francesco Peri · 2011 · MedChemComm
  78. A mouse model to identify cooperating signaling pathways in cancer
    Mónica Musteanu, Leander Blaas, Rainer Zenz, Jasmin Svinka, Thomas Hoffmann, Beatrice Grabner, Daniel Schramek, Hans-Peter Kantner, Mathias M. Müller, Thomas Kolbe et al. · 2012 · Nature Methods
  79. Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma
    Joshua T. Kowalczyk, Xiaolin Wan, Edjay R. Hernandez, Ruibai Luo, Gaelyn C. Lyons, Kelli M. Wilson, Devorah C. Gallardo, Kristine A. Isanogle, Christina M. Robinson, Arnulfo Mendoza et al. · 2020 · Molecular Cancer Therapeutics
  80. Nutritional vitamin B12 regulates RAS/MAPK-mediated cell fate decisions through one-carbon metabolism
    Ana Cristina Laranjeira, Simon Berger, Tea Kohlbrenner, Nadja R. Greter, Alex Hajnal · 2024 · Nature Communications
  81. Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress
    Kai Aoki, Koki Yanazawa, Katsuyuki Tokinoya, Takehito Sugasawa, Takuji Suzuki, Yukiko Yoshida, Takuro Nakano, Naomi Omi, Yasushi Kawakami, Kazuhiro Takekoshi · 2020 · Life Sciences
  82. ERK2 stimulates MYC transcription by anchoring CDK9 to the MYC promoter in a kinase activity–independent manner
    Lorena Agudo‐Ibáñez, Marta Morante, Lucia García-Gutiérrez, Andrea Quintanilla, Javier Rodríguez, Alberto Múñoz, Javier León, Piero Crespo · 2023 · Science Signaling
  83. Regulation of CBP and Tip60 coordinates histone acetylation at local and global levels during Ras-induced transformation
    Sara Sánchez-Molina, Conchi Estarás, José Luís Oliva, Naiara Akizu, Elena Asensio-Juan, José M. Rojas, Marian A. Martínez‐Balbás · 2014 · Carcinogenesis
  84. Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF
    Marta Martins, Sean C. Warren, Christopher Kimberley, Anca Margineanu, Pascal Peschard, Afshan McCarthy, Maggie Yeo, Christopher J. Marshall, Christopher W. Dunsby, P. M. W. French et al. · 2012 · Journal of Cell Science
  85. Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS
    Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Ruan · 2018 · Royal Society Open Science
  86. ERF deletion rescues RAS deficiency in mouse embryonic stem cells
    Cristina Mayor‐Ruiz, Teresa Olbrich, Matthias Drosten, Emilio Lecona, María Vega-Sendino, Sagrario Ortega, Orlando Domı́nguez, Mariano Barbacid, Sergio Ruiz, Óscar Fernández-Capetillo · 2018 · Genes & Development
  87. Design of small molecules that compete with nucleotide binding to an engineered oncogenic KRAS allele
    Zhang, Yan, Larraufie, Marie-Hélène, Musavi, Leila, Akkiraju, Hemanth, Brown, Lewis M., Stockwell, Brent R. · 2018 · Biochemistry
  88. Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment
    Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai · 2025 · Advanced Science
  89. Chromosome-Level Genome Assembly of the Speckled Blue Grouper (Epinephelus cyanopodus) Provides Insight into Its Adaptive Evolution
    Xiaoying Cao, Jiajun Zhang, Shunyun Deng, Shaoxiong Ding · 2022 · Biology
  90. Activated N-Ras signaling regulates arterial-venous specification in zebrafish
    Chunguang Ren, Lei Wang, Xiaoe Jia, Yijie Liu, Zhiwei Dong, Yi Jin, Yi Chen, Min Deng, Yong Zhou, Yi Zhou et al. · 2013 · Journal of Hematology & Oncology
  91. Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association
    Michael Whaby, Lauren Wallon, Megan Mazzei, Imran Khan, Kai Wen Teng, Shohei Koide, John P. O’Bryan · 2022 · Journal of Biological Chemistry
  92. New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics
    Dominic Esposito, Andrew G. Stephen, Thomas J. Turbyville, Matthew T. Holderfield · 2018 · Seminars in Cancer Biology
  93. Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants
    Jasmin B. Post, Jeanine M.L. Roodhart, Hugo J.G. Snippert · 2020 · Trends in cancer
  94. RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines
    Caleb K. Stubbs, Marco Biancucci, Vania Vidimar, K.J.F. Satchell · 2021 · Scientific Reports
  95. Novel RAF ‐directed approaches to overcome current clinical limits and block the RAS / RAF node
    Rossella Scardaci, Ewa Berlinska, Pietro Scaparone, Sandra Vietti Michelina, Edoardo Garbo, Silvia Novello, David Santamarı́a, Chiara Ambrogio · 2024 · Molecular Oncology
  96. Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications
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  97. Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement
    Ki‐Young Lee, Zhenhao Fang, Masahiro Enomoto, Geneviève M. C. Gasmi-Seabrook, Le Zheng, Shohei Koide, Mitsuhiko Ikura, Christopher B. Marshall · 2020 · Angewandte Chemie
  98. Mammalian protein expression noise: scaling principles and the implications for knockdown experiments
    Marc R. Birtwistle, Alex von Kriegsheim, Maciej Dobrzyński, Boris Ν. Kholodenko, Walter Kölch · 2012 · Molecular BioSystems
  99. Depletion of K-Ras promotes proteasome degradation of survivin
    Awet Tecleab, Saı̈d M. Sebti · 2013 · Cell Cycle
  100. High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models
    Juan Carlos Álvarez-Pérez, Juan Sanjuán‐Hidalgo, Alberto M. Arenas, Ivan Hernández-Navas, Maria S. Benitez‐Cantos, Álvaro Andrades, Silvia Calabuig Fariñas, Eloisa Jantus Lewintre, Luis G Paz-Ares, Irene Ferrer et al. · 2025 · Nature Communications