The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor
Open accessAbstract
Self-renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3. Several targets of Stat3 have previously been identified, most notably the reprogramming factor Klf4. However, such factors are neither required nor sufficient for the potent effect of LIF. We took advantage of Stat3 null ES cells to confirm that Stat3 mediates the self-renewal response to LIF. Through comparative transcriptome analysis intersected with genome location data, we arrived at a set of candidate transcription factor effectors. Among these, Tfcp2l1 (also known as Crtr-1) was most abundant. Constitutive expression of Tfcp2l1 at levels similar to those induced by LIF effectively substituted for LIF or Stat3 in sustaining clonal self-renewal and pluripotency. Conversely, knockdown of Tfcp2l1 profoundly compromised responsiveness to LIF. We further found that Tfcp2l1 is both necessary and sufficient to direct molecular reprogramming of post-implantation epiblast stem cells to naïve pluripotency. These results establish Tfcp2l1 as the principal bridge between LIF/Stat3 input and the transcription factor core of naïve pluripotency.
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The ground state of embryonic stem cell self-renewal
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Self-citationZhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070
Fast and SNP-tolerant detection of complex variants and splicing in short reads
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A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
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Cited by
Formative pluripotency: the executive phase in a developmental continuum
Smith, A. (2017) · Development · doi:10.1242/dev.142679 · Cited by 474
Self-citationBoroviak, T., Loos, R., Bertone, P., Smith, A., & Nichols, J. (2014) · Nature Cell Biology · doi:10.1038/ncb2965 · Cited by 441
Self-citationDefining an essential transcription factor program for naïve pluripotency
Dunn, S.-J., Martello, G., Yordanov, B., Emmott, S., & Smith, A. G. (2014) · Science · doi:10.1126/science.1248882 · Cited by 370
Self-citationMyc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, Á. M., Baumgärtner, D., Carnevalli, L. S., Atzberger, A., Haas, S., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.033 · Cited by 271
Self-citationDo all roads lead to Oct4? The emerging concepts of induced pluripotency
Radzisheuskaya, A., & Silva, J. C. R. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.11.010 · Cited by 101
Metadata
- Authors
- Martello, G., Bertone, P., & Smith, A.
- Venue
- The EMBO Journal
- Published
- 2013-08-13
- Volume
- 32
- Issue
- 19
- Pages
- 2561-2574
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2094099211
- Cited by
- 219
- References
- 5
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
