The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Formative pluripotency: the executive phase in a developmental continuum
Open accessAbstract
The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception of pluripotency as an intrinsically metastable and precarious state. However, in the embryo and in defined culture environments the properties of pluripotent cells change in an orderly sequence. Two phases of pluripotency, called naïve and primed, have previously been described. In this Hypothesis article, a third phase, called formative pluripotency, is proposed to exist as part of a developmental continuum between the naïve and primed phases. The formative phase is hypothesised to be enabling for the execution of pluripotency, entailing remodelling of transcriptional, epigenetic, signalling and metabolic networks to constitute multi-lineage competence and responsiveness to specification cues.
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Cites
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
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Self-citationFunctional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
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Cited by
Molotkov, A., Mazot, P., Brewer, J. R., Cinalli, R. M., & Soriano, P. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.004 · Cited by 177
Messmer, T., von Meyenn, F., Savino, A., Santos, F., Mohammed, H., Lun, A. T. L., Marioni, J. C., & Reik, W. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.099 · Cited by 156
Kang, M., Garg, V., & Hadjantonakis, A.-K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.003 · Cited by 174
Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells
Goel, A. J., Rieder, M.-K., Arnold, H.-H., Radice, G. L., & Krauss, R. S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.102 · Cited by 146
Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, M., et al. (2019) · Cell Systems · doi:10.1016/j.cels.2019.03.012 · Cited by 146
Metadata
- Authors
- Smith, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2017-02-01
- Volume
- 144
- Issue
- 3
- Pages
- 365-373
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2583932040
- Cited by
- 474
- References
- 124
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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