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Do all roads lead to Oct4? The emerging concepts of induced pluripotency

Radzisheuskaya, Aliaksandra, Silva, José C.R.·2014·Trends in Cell Biology

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  • OCT4 is the master regulator of epigenetic reprogramming.

    “Multiple studies have suggested OCT4 (Fig. 1a) as the master regulator of epigenetic reprogramming [31][32][33] , as OCT4 overexpression alone is sufficient to induce pluripotency when other canonical reprogramming factors are endogenously expressed or are in the presence of other chromatin remodeling chemical factors 32,34,35 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [33]

    The Concluding remarks call Oct4 an essential transcriptional regulator in reprogramming, and ‘Overcoming epigenetic barriers’ describes its role in opening repressed chromatin. But ‘Molecular mechanisms of Oct4 in reprogramming’ says its precise mechanism remains unclear, while the epigenetic-barrier section describes its possible role in overcoming a specific barrier. The paper does not establish Oct4 as the master regulator of epigenetic reprogramming. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • OSKM facilitates MET by suppressing the regulation of epithelial-to-mesenchymal transition through multiple mechanisms, such as OCT4 and MYC repression of TGFβ signaling, OCT4 and SOX2 activation of miR-200 family, and OCT4 and KLF4 chromatin opening and activation of epithelial genes.

    “Interestingly, OSKM facilitates MET by suppressing the regulation of epithelial-to-mesenchymal transition through multiple mechanisms, such as OCT4 and MYC repression of TGFβ signaling 33,94 , OCT4 and SOX2 activation of miR-200 family 33,98 , and OCT4 and KLF4 chromatin opening and activation of epithelial genes 37 .”

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Metadata

Authors
Radzisheuskaya, A., & Silva, J. C. R.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2014-05
Volume
24
Issue
5
Pages
275-284
ISSN
0962-8924
Cited by
101
References
9
Language
en

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