The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ribosomal proteins are targets for the NEDD8 pathway
Open accessAbstract
Identification of the molecular targets for post‐translational modifications is an important step for explaining the regulated pathways. The ubiquitin‐like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.
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Cites
Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins
Lam, Y. W., Lamond, A. I., Mann, M., & Andersen, J. S. (2007) · Current Biology · doi:10.1016/j.cub.2007.03.064 · Cited by 369
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
Kirkpatrick, D. S., Denison, C., & Gygi, S. P. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-750 · Cited by 209
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
Xirodimas, D., Saville, M. K., Edling, C., Lane, D. P., & Laín, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204656 · Cited by 169
Self-citation
Cited by
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
Kim, W., Bennett, E. J., Huttlin, E. L., Guo, A., Li, J., Possemato, A., Sowa, M. E., Rad, R., Rush, J., Comb, M. J., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.025 · Cited by 1,613
Duda, D. M., Borg, L. A., Scott, D. C., Hunt, H. W., Hammel, M., & Schulman, B. A. (2008) · Cell · doi:10.1016/j.cell.2008.07.022 · Cited by 767
Protein neddylation: beyond cullin–RING ligases
Enchev, R. I., Schulman, B. A., & Peter, M. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3919 · Cited by 615
E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification
Huang, D. T., Ayrault, O., Hunt, H. W., Taherbhoy, A. M., Duda, D. M., Scott, D. C., Borg, L. A., Neale, G., Murray, P. J., Roussel, M. F., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.011 · Cited by 282
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy
Soucy, T. A., Dick, L. R., Smith, P. G., Milhollen, M. A., & Brownell, J. E. (2010) · Genes & Cancer · doi:10.1177/1947601910382898 · Cited by 225
Metadata
- Authors
- Xirodimas, D. P., Sundqvist, A., Nakamura, A., Shen, L., Botting, C., & Hay, R. T.
- Venue
- EMBO reports
- Published
- 2008-02-15
- Volume
- 9
- Issue
- 3
- Pages
- 280-286
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2021029501
- Cited by
- 175
- References
- 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Xirodimas, D. P., Sundqvist, A., Nakamura, A., Shen, L., Botting, C., & Hay, R. T. (2008). Ribosomal proteins are targets for the NEDD8 pathway. EMBO reports. https://doi.org/10.1038/embor.2008.10
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