The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Protein neddylation: beyond cullin–RING ligases
Open accessAbstract
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING ligases. Many non-cullin neddylation targets have been proposed in recent years. However, overexpression of exogenous NEDD8 can trigger NEDD8 conjugation through the ubiquitylation machinery, which makes validating potential NEDD8 targets challenging. Here, we re-evaluate studies of non-cullin targets of NEDD8 in light of the current understanding of the neddylation pathway, and suggest criteria for identifying genuine neddylation substrates under homeostatic conditions. We describe the biological processes that might be regulated by non-cullin neddylation, and the utility of neddylation inhibitors for research and as potential therapies. Understanding the biological significance of non-cullin neddylation is an exciting research prospect primed to reveal fundamental insights.
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Cites
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Metadata
- Authors
- Enchev, R. I., Schulman, B. A., & Peter, M.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-12-22
- Volume
- 16
- Issue
- 1
- Pages
- 30-44
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2066745745
- Cited by
- 615
- References
- 173
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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