Cited by 323Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCalcium signaling and nucleotide metabolism

PLIC proteins or ubiquilins regulate autophagy‐dependent cell survival during nutrient starvation

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N'Diaye, Elsa‐Noah, Kajihara, Kimberly K, Hsieh, Ivy, Morisaki, Hiroshi, Debnath, Jayanta, Brown, Eric J·2009·The EMBO Reports

Abstract

Ubiquilins (UBQLNs) are adaptor proteins thought to deliver ubiquitinated substrates to proteasomes. Here, we show a role for UBQLN in autophagy: enforced expression of UBQLN protects cells from starvation-induced death, whereas depletion of UBQLN renders cells more susceptible. The UBQLN protective effect requires the autophagy-related genes ATG5 and ATG7, two essential components of autophagy. The ubiquitin-associated domain of UBQLN mediates both its association with autophagosomes and its protective effect against starvation. Depletion of UBQLN delays the delivery of autophagosomes to lysosomes. This study identifies a new role for UBQLN in regulating the maturation of autophagy, expanding the involvement of ubiquitin-related proteins in this process.

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Crossref · 10.1038/embor.2008.238

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Authors
N'Diaye, E., Kajihara, K. K., Hsieh, I., Morisaki, H., Debnath, J., & Brown, E. J.
Affiliations
Genentech (US)
Venue
The EMBO Reports
Published
2009-01-16
Volume
10
Issue
2
Pages
173-179
ISSN
  • 1469-221X (ISSN-L)
  • 1469-3178
OpenAlex
W2144022982
Cited by
323
References
36
Citations by year
2026: 11 · 2025: 14 · 2024: 16 · 2023: 25 · 2022: 20 · 2021: 22 · 2020: 39 · 2019: 25 · 2018: 30 · 2017: 31 · 2016: 22 · 2015: 18 · 2014: 12 · 2013: 12 · 2012: 5
FWCI
5.85
Type
journal article
Language
en
Open access
Locations
  • EMBO Reports (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Washington University in St. Louis
  • National Institutes of Health
  • University of California, San Francisco
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
ubiquilin, autophagy, nutrient deprivation, ATG5, ATG7, ubiquitin-associated domain, autophagosome maturation, autophagosome-lysosome fusion, cell survival
MeSH terms
Autophagy-Related Proteins, Autophagy-Related Protein 5, Autophagy-Related Protein 7, Animals, Autophagy, Carrier Proteins, Culture Media, HeLa Cells, Humans, Microtubule-Associated Proteins, Phagosomes, Recombinant Fusion Proteins, Ubiquitins, Microscopy, Immunoelectron, Protein Structure, Tertiary, Cell Cycle Proteins, Protein Interaction Mapping, Adaptor Proteins, Vesicular Transport, RNA Interference, RNA, Small Interfering, Ubiquitin-Activating Enzymes, Adaptor Proteins, Signal Transducing, Mice

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