The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB
Open accessAbstract
Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA‐dependent activator of IRFs/Z‐DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nuclear factor‐kappa B (NF‐κB) transcription factors, leading to type‐I interferon production. DAI‐induced IRF activation depends on TANK‐binding kinase 1 (TBK1), whereas signalling pathways and molecular components involved in NF‐κB activation remain elusive. Here, we report the identification of two receptor‐interacting protein (RIP) homotypic interaction motifs (RHIMs) in the DAI protein sequence, and show that these domains relay DAI‐induced NF‐κB signals through the recruitment of the RHIM‐containing kinases RIP1 and RIP3. We show that knockdown of not only RIP1, but also RIP3 affects DAI‐induced NF‐κB activation. Importantly, RIP recruitment to DAI is inhibited by the RHIM‐containing murine cytomegalovirus (MCMV) protein M45. These findings delineate the DAI signalling pathway to NF‐κB and suggest a possible new immune modulation strategy of the MCMV.
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Cites
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401
Self-citationAIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831
Cited by
Li, J., McQuade, T., Siemer, A. B., Napetschnig, J., Moriwaki, K., Hsiao, Y.-S., Damko, E., Moquin, D., Walz, T., McDermott, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.019 · Cited by 1,222
Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
Kaiser, W. J., Sridharan, H., Huang, C., Mandal, P., Upton, J. W., Gough, P. J., Sehon, C. A., Marquis, R. W., Bertin, J., & Mocarski, E. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.462341 · Cited by 959
Kuriakose, T., Man, S. M., Subbarao Malireddi, R. K., Karki, R., Kesavardhana, S., Place, D. E., Neale, G., Vogel, P., & Kanneganti, T.-D. (2016) · Science Immunology · doi:10.1126/sciimmunol.aag2045 · Cited by 818
Upton, J. W., Kaiser, W. J., & Mocarski, E. S. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.016 · Cited by 758
Initiation and execution mechanisms of necroptosis: an overview
Grootjans, S., Vanden Berghe, T., & Vandenabeele, P. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.65 · Cited by 566
Metadata
- Authors
- Rebsamen, M., Heinz, L. X., Meylan, E., Michallet, M., Schroder, K., Hofmann, K., Vazquez, J., Benedict, C. A., & Tschopp, J.
- Venue
- EMBO reports
- Published
- 2009-07-10
- Volume
- 10
- Issue
- 8
- Pages
- 916-922
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2118038164
- Cited by
- 367
- References
- 3
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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