ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
Open accessAbstract
ZBP1 activates the NLRP3 inflammasome and programmed cell death.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple components of molecular machinery for necroptosis-including ZBP1, RIPK3, MLKL, and TNFR1 (mainly via NF-κB)-impinge on control of inflammasome, a supramolecular platform for activation of CASP1 and consequent secretion of mature IL1B and IL18.
“Importantly, multiple components of the molecular machinery for necroptosis—including ZBP1, RIPK3, MLKL, and TNFR1 (mainly via NF-κB)—impinge on the control of the so-called “inflammasome”, a supramolecular platform for the activation of CASP1 and consequent secretion of mature interleukin 1 beta (IL1B; best known as IL-1β) and IL18 [524–529].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [525]
Type I IFN and IFNG contribute to pyroptosis by promoting TLR7, CGAS, STING, RIG-I, or MAVS signaling upon bacterial or viral infection.
“(2) TLR7, cyclic GMP-AMP synthase (CGAS), transmembrane protein 173 (TMEM173; best known as STING), DExD/H-box helicase 58 (DDX58; best known as RIG-I), or mitochondrial antiviral signaling protein (MAVS) signaling upon bacterial or viral infection [525, 645]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [525]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698 · see citing works
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
de Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J. D., Chau, T. N. B., Hoang, D. M., Van Vinh Chau, N., Khanh, T. H., Dong, V. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1477 · Cited by 1,858 · see citing works
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,704 · see citing works
1918 Influenza: the Mother of All Pandemics
Taubenberger, J. K., & Morens, D. M. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.050979 · Cited by 1,686 · see citing works
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278 · see citing works
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.018 · Cited by 1,220 · see citing works
Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113 · see citing works
Innate immunity to influenza virus infection
Iwasaki, A., & Pillai, P. S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3665 · Cited by 1,064 · see citing works
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057 · see citing works
A novel influenza A virus mitochondrial protein that induces cell death
Chen, W., Calvo, P. A., Malide, D. A., Gibbs, J. S., Schubert, U., Bačík, I., Basta, S., O’Neill, R. E., Schickli, J. H., Palese, P., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1306 · Cited by 1,037 · see citing works
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021 · see citing works
IFITM3 restricts the morbidity and mortality associated with influenza
The GenISIS Investigators, Everitt, A. R., The MOSAIC Investigators, Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R., Feeley, E. M., et al. (2012) · Nature · doi:10.1038/nature10921 · Cited by 783 · see citing works
Upton, J. W., Kaiser, W. J., & Mocarski, E. S. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.016 · Cited by 758 · see citing works
Thomas, P. G., Dash, P., Aldridge, J. R., Ellebedy, A. H., Reynolds, C., Funk, A. J., Martin, W. J., Lamkanfi, M., Webby, R. J., Boyd, K. L., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.006 · Cited by 749 · see citing works
Self-citationKanneganti, T., Body–Malapel, M., Amer, A. O., Park, J., Whitfield, J. R., Franchi, L., Taraporewala, Z. F., Miller, D. J., Patton, J. T., Inohara, N., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607594200 · Cited by 706 · see citing works
Self-citationConverging roles of caspases in inflammasome activation, cell death and innate immunity
Man, S. M., & Kanneganti, T. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.7 · Cited by 701 · see citing works
Self-citationActivity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
Newton, K., Dugger, D. L., Wickliffe, K. E., Kapoor, N., de Almagro, M. C., Vucic, D., Komuves, L., Ferrando, R. E., French, D. M., Webster, J., et al. (2014) · Science · doi:10.1126/science.1249361 · Cited by 687 · see citing works
Inflammasome recognition of influenza virus is essential for adaptive immune responses
Ichinohe, T., Lee, H. K., Ogura, Y., Flavell, R. A., & Iwasaki, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081667 · Cited by 682 · see citing works
Influenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe, T., Pang, I. K., & Iwasaki, A. (2010) · Nature Immunology · doi:10.1038/ni.1861 · Cited by 632 · see citing works
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ishii, K. J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., et al. (2008) · Nature · doi:10.1038/nature06537 · Cited by 628 · see citing works
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Mandal, P., Berger, S. B., Pillay, S., Moriwaki, K., Huang, C., Guo, H., Lich, J. D., Finger, J. N., Kasparcova, V., Votta, B. J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.021 · Cited by 619 · see citing works
Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408987111 · Cited by 598 · see citing works
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
Kash, J. C., Tumpey, T. M., Proll, S. C., Carter, V., Perwitasari, O., Thomas, M. J., Basler, C. F., Palese, P., Taubenberger, J. K., García-Sastre, A., et al. (2006) · Nature · doi:10.1038/nature05181 · Cited by 551 · see citing works
Brandes, M., Klauschen, F., Kuchen, S., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.06.013 · Cited by 379 · see citing works
Pathogenic potential of interferon αβ in acute influenza infection
Davidson, S., Crotta, S., McCabe, T. M., & Wack, A. (2014) · Nature Communications · doi:10.1038/ncomms4864 · Cited by 370 · see citing works
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB
Rebsamen, M., Heinz, L. X., Meylan, E., Michallet, M., Schroder, K., Hofmann, K., Vázquez, J., Benedict, C. A., & Tschopp, J. (2009) · EMBO Reports · doi:10.1038/embor.2009.109 · Cited by 365 · see citing works
Nogusa, S., Thapa, R. J., Dillon, C. P., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.011 · Cited by 364 · see citing works
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
Thapa, R. J., Nogusa, S., Chen, P., Maki, J. L., Lerro, A., Andrake, M., Rall, G. F., Degterev, A., & Balachandran, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301218110 · Cited by 355 · see citing works
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
Wang, Z., Choi, M. K., Ban, T., Yanai, H., Negishi, H., Lu, Y., Tamura, T., Takaoka, A., Nishikura, K., & Taniguchi, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801295105 · Cited by 337 · see citing works
Li, S., Wang, L., Berman, M. A., Kong, Y., & Dorf, M. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.014 · Cited by 334 · see citing works
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
Wang, X., Jiang, W., Yan, Y., Gong, T., Han, J., Tian, Z., & Zhou, R. (2014) · Nature Immunology · doi:10.1038/ni.3015 · Cited by 323 · see citing works
Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins
Schwartz, T., Behlke, J., Lowenhaupt, K., Heinemann, U., & Rich, A. (2018) · Nature Structural Biology · doi:10.1038/nsb0901-761 · Cited by 297 · see citing works
Balachandran, S., Roberts, P. C., Kipperman, T., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.3.1513-1523.2000 · Cited by 295 · see citing works
Kaiser, W. J., Upton, J. W., & Mocarski, E. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6427 · Cited by 277 · see citing works
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.008 · Cited by 255 · see citing works
McAuley, J., Tate, M. D., Mackenzie-Kludas, C., Pinar, A. A., Zeng, W., Stutz, A., Latz, E., Brown, L. E., & Mansell, A. S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003392 · Cited by 247 · see citing works
Pothlichet, J., Meunier, I., Davis, B. K., Ting, J. P.-Y., Skamene, E., von Messling, V., & Vidal, S. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003256 · Cited by 225 · see citing works
Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1
DeFilippis, V. R., Alvarado, D. M., Sali, T. M., Rothenburg, S., & Früh, K. (2009) · Journal of Virology · doi:10.1128/jvi.01748-09 · Cited by 204 · see citing works
McComb, S., Cessford, E., Alturki, N. A., Joseph, J., Shutinoski, B., Startek, J. B., Gamero, A. M., Mossman, K. L., & Sad, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407068111 · Cited by 190 · see citing works
Rodrigue‐Gervais, I. G., Labbè, K., Dagenais, M., Dupaul-Chicoine, J., Champagne, C., Morizot, A., Skeldon, A. M., Brincks, E. L., Vidal, S. M., Griffith, T. S., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2013.12.003 · Cited by 161 · see citing works
A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
Moriwaki, K., Bertin, J., Gough, P. J., & Chan, F. K.-M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402167 · Cited by 161 · see citing works
RNase L Activates the NLRP3 Inflammasome during Viral Infections
Chakrabarti, A., Banerjee, S., Franchi, L., Loo, Y., Gale, M., Núñez, G., & Silverman, R. H. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.02.010 · Cited by 148 · see citing works
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors
Chen, N., Chio, I. I. C., Lin, W., Duncan, G. S., Chau, H., Katz, D., Huang, H.-L., Pike, K. A., Hao, Z., Su, Y.-W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806585105 · Cited by 116 · see citing works
Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury
Herold, S., Ludwig, S., Pleschka, S., & Wolff, T. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011530 · Cited by 114 · see citing works
Herold, S., Tabar, T. S., Janßen, H., Högner, K., Cabanski, M., Lewe-Schlosser, P., Albrecht, J., Driever, F., Vadász, I., Seeger, W., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201009-1431oc · Cited by 110 · see citing works
Sanders, C. J., Vogel, P., McClaren, J. L., Bajracharya, R., Doherty, P. C., & Thomas, P. G. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00343.2012 · Cited by 72 · see citing works
Self-citationDNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1
Pham, T. H., Kwon, K. M., Kim, Y.-E., Kim, K. K., & Ahn, J. (2013) · Journal of Virology · doi:10.1128/jvi.02860-12 · Cited by 69 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734 · see citing works
Self-citationNLRP3 inflammasome activation and cell death
Huang, Y., Xu, W., & Zhou, R. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00740-6 · Cited by 1,527 · see citing works
Christgen, S., Zheng, M., Kesavardhana, S., Karki, R., Malireddi, R. K. S., Banoth, B., Place, D. E., Briard, B., Sharma, B. R., Tuladhar, S., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00237 · Cited by 588 · see citing works
Self-citationSamir, P., Malireddi, R. K. S., & Kanneganti, T.-D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00238 · Cited by 557 · see citing works
Self-citationWang, Y., & Kanneganti, T.-D. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.07.038 · Cited by 545 · see citing works
Self-citationRIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
Lin, J., Kumari, S., Kim, C., Van, T.-M., Wachsmuth, L., Polykratis, A., & Pasparakis, M. (2016) · Nature · doi:10.1038/nature20558 · Cited by 421 · see citing works
RIPK1 inhibits ZBP1-driven necroptosis during development
Newton, K., Wickliffe, K. E., Maltzman, A., Dugger, D. L., Strasser, A., Pham, V. C., Lill, J. R., Roose-Girma, M., Warming, S., Solon, M., et al. (2016) · Nature · doi:10.1038/nature20559 · Cited by 390 · see citing works
Cytosolic DNA Sensing in Organismal Tumor Control
Vanpouille-Box, C., Demaria, S., Formenti, S. C., & Galluzzi, L. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.05.013 · Cited by 250 · see citing works
Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis
Maelfait, J., Liverpool, L., Bridgeman, A., Ragan, K. B., Upton, J. W., & Rehwinkel, J. (2017) · The EMBO Journal · doi:10.15252/embj.201796476 · Cited by 237 · see citing works
Banoth, B., Tuladhar, S., Karki, R., Sharma, B. R., Briard, B., Kesavardhana, S., Burton, A., & Kanneganti, T.-D. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015924 · Cited by 237 · see citing works
Self-citationRIPK1 Distinctly Regulates <i>Yersinia</i>-Induced Inflammatory Cell Death, PANoptosis
Malireddi, R. K. S., Kesavardhana, S., Karki, R., Kancharana, B., Burton, A. R., & Kanneganti, T.-D. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000097 · Cited by 224 · see citing works
Self-citationATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING
Aden, K., Tran, F., Ito, G., Sheibani-Tezerji, R., Lipinski, S., Kuiper, J. W., Tschurtschenthaler, M., Saveljeva, S., Bhattacharyya, J., Häsler, R., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171029 · Cited by 167 · see citing works
Lee, E., Song, C.-H., Bae, S.-J., Ha, K.-T., & Karki, R. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01069-y · Cited by 164 · see citing works
Self-citationThe NLRP3 inflammasome renders cell death pro-inflammatory
Gaidt, M. M., & Hornung, V. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.11.013 · Cited by 124 · see citing works
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling · doi:10.1126/scisignal.abc6178 · Cited by 82 · see citing works
ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway
Yan, S., Yu, L., Chen, Z., Xie, D., Huang, Z., & Ouyang, S. (2024) · Annals of Hepatology · doi:10.1016/j.aohep.2024.101475 · Cited by 21 · see citing works
- Authors
- Kuriakose, T., Man, S. M., Subbarao Malireddi, R. K., Karki, R., Kesavardhana, S., Place, D. E., Neale, G., Vogel, P., & Kanneganti, T.-D.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- Corresponding author
- Kanneganti, Thirumala-Devi
- ORCID
- Venue
- Science Immunology
- Published
- 2016-08-05
- Volume
- 1
- Issue
- 2
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC5131924
- OpenAlex
- W2507605260
- Cited by
- 818
- References
- 48
- Citations by year
- 2026: 96 · 2025: 161 · 2024: 115 · 2023: 105 · 2022: 75 · 2021: 75 · 2020: 77 · 2019: 38 · 2018: 35 · 2017: 36 · 2016: 5
- FWCI
- 23.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Cancer Institute (R01CA163507, P30CA021765)
- National Institute of Allergy and Infectious Diseases (R01AI101935, R37AI101935, R01AI124346)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056296)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- ZBP1, DAI, influenza A virus, innate immune recognition, NLRP3 inflammasome, RIPK1, RIPK3, caspase-8, necroptosis, pyroptosis, apoptosis, interferon-induced proteins, viral pathogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
