The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells
Open accessAbstract
Recent studies have indicated that nuclear protein of 95 kDa (Np95) is essential for maintaining genomic methylation by recruiting DNA methyltransferase (Dnmt) 1 to hemi‐methylated sites. Here, we show that Np95 interacts more strongly with regulatory domains of the de novo methyltransferases Dnmt3a and Dnmt3b. To investigate possible functions, we developed an epigenetic silencing assay using fluorescent reporters in embryonic stem cells (ESCs). Interestingly, silencing of the cytomegalovirus promoter in ESCs preceded DNA methylation and was strictly dependent on the presence of either Np95, histone H3 methyltransferase G9a or Dnmt3a and Dnmt3b. Our results indicate a regulatory role for Np95, Dnmt3a and Dnmt3b in mediating epigenetic silencing through histone modification followed by DNA methylation.
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Cites
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816
Cited by
Quenneville, S., Verde, G., Corsinotti, A., Kapopoulou, A., Jakobsson, J., Offner, S., Baglivo, I., Pedone, P. V., Grimaldi, G., Riccio, A., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.032 · Cited by 606
De novo DNA methylation: a germ cell perspective
Smallwood, S. A., & Kelsey, G. (2012) · Trends in Genetics · doi:10.1016/j.tig.2011.09.004 · Cited by 448
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells
Saitou, M., Kagiwada, S., & Kurimoto, K. (2012) · Development · doi:10.1242/dev.050849 · Cited by 414
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Li, Y., Chen, X., & Lu, C. (2021) · The EMBO Reports · doi:10.15252/embr.202051803 · Cited by 223
Sharma, S., De Carvalho, D. D., Jeong, S., Jones, P. A., & Liang, G. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001286 · Cited by 119
Metadata
- Authors
- Meilinger, D., Fellinger, K., Bultmann, S., Rothbauer, U., Bonapace, I. M., Klinkert, W. E. F., Spada, F., & Leonhardt, H.
- Venue
- EMBO reports
- Published
- 2009-10-02
- Volume
- 10
- Issue
- 11
- Pages
- 1259-1264
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2165957545
- Cited by
- 194
- References
- 4
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Meilinger, D., Fellinger, K., Bultmann, S., Rothbauer, U., Bonapace, I. M., Klinkert, W. E. F., Spada, F., & Leonhardt, H. (2009). Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO reports. https://doi.org/10.1038/embor.2009.201
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