Cited by 654TGF-β signaling in diseasesCell Adhesion Molecules ResearchProtease and Inhibitor Mechanisms

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Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing

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Margadant, Coert, Sonnenberg, Arnoud·2010·The EMBO Reports

DOI 10.1038/embor.2009.276PMC PMC2828749

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Abstract

Accumulating evidence indicates that there is extensive crosstalk between integrins and TGF-beta signalling. TGF-beta affects integrin-mediated cell adhesion and migration by regulating the expression of integrins, their ligands and integrin-associated proteins. Conversely, several integrins directly control TGF-beta activation. In addition, a number of integrins can interfere with both Smad-dependent and Smad-independent TGF-beta signalling in different ways, including the regulation of the expression of TGF-beta signalling pathway components, the physical association of integrins with TGF-beta receptors and the modulation of downstream effectors. Reciprocal TGF-beta-integrin signalling is implicated in normal physiology, as well as in a variety of pathological processes including systemic sclerosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cancer; thus, integrins could provide attractive therapeutic targets to interfere with TGF-beta signalling in these processes.

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Authors: Margadant, C., & Sonnenberg, A.
Affiliations: The Netherlands Cancer Institute (NL)
Corresponding author: Sonnenberg, Arnoud
ORCID: Margadant, Coert
Sonnenberg, Arnoud
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2010-01-15
Volume: 11
Issue: 2
Pages: 97-105
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1038/embor.2009.276
PMC: PMC2828749
OpenAlex: W2112195516
Cited by: 653
References: 81
Citations by year: 2026: 28 · 2025: 50 · 2024: 32 · 2023: 41 · 2022: 30 · 2021: 38 · 2020: 41 · 2019: 34 · 2018: 45 · 2017: 38 · 2016: 45 · 2015: 43 · 2014: 49 · 2013: 36 · 2012: 51
FWCI: 3.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: European Molecular Biology Organization
Dystrophic Epidermolysis Bullosa Research Association
KWF Kankerbestrijding
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: TGF-beta signaling, integrins, Smad signaling, TGF-beta receptor, cell adhesion, cell migration, fibrosis, systemic sclerosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, cancer, wound healing, therapeutic target
MeSH terms: Animals, Fibrosis, Humans, Models, Biological, Neoplasms, Wound Healing, Integrins, Transforming Growth Factor beta, Disease Progression, Receptor Cross-Talk

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Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing

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