The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?
Open accessAbstract
Epithelial‐to‐mesenchymal transition (EMT) is a fundamental process in development and disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are crucial EMT activators, whereas members of the miR‐200 family induce epithelial differentiation. They are reciprocally linked in a feedback loop, each strictly controlling the expression of the other. Now data show that EMT not only confers cellular motility, but also induces stem‐cell properties and prevents apoptosis and senescence. Thus the balanced expression of ZEB factors and miR‐200 controls all these processes. We therefore propose that the ZEB/miR‐200 feedback loop is the molecular motor of cellular plasticity in development and disease, and in particular is a driving force for cancer progression towards metastasis by controlling the state of cancer stem cells.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
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Jung, A., Schrauder, M., Oswald, U., Knoll, C., Sellberg, P., Palmqvist, R., Niedobitek, G., Brabletz, T., & Kirchner, T. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63007-6 · Cited by 217
Self-citation
Cited by
Brabletz, T., Kalluri, R., Nieto, M. A., & Weinberg, R. A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.118 · Cited by 1,961
Self-citationThe epigenetics of epithelial-mesenchymal plasticity in cancer
Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,163
Epithelial-mesenchymal transitions: insights from development
Lim, J., & Thiery, J. P. (2012) · Development · doi:10.1242/dev.071209 · Cited by 661
A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma
Caramel, J., Papadogeorgakis, E., Hill, L., Browne, G. J., Richard, G., Wierinckx, A., Saldanha, G., Osborne, J., Hutchinson, P., Tse, G., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.018 · Cited by 517
Zhang, J., Tian, X.-J., Zhang, H., Teng, Y., Li, R., Bai, F., Elankumaran, S., & Xing, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005304 · Cited by 462
Metadata
- Authors
- Brabletz, S., & Brabletz, T.
- Venue
- EMBO reports
- Published
- 2010-08-13
- Volume
- 11
- Issue
- 9
- Pages
- 670-677
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2101136328
- Cited by
- 793
- References
- 6
- FWCI
- 27.07
- Type
- journal article
- Language
- en
- Open access
- green
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