EMT in cancer
Abstract
Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.
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Mutations in IDH1/2 are the most frequently mutated metabolic genes in human cancer.
“In recent years, two landmark genomic studies carried out in human glioma and acute myeloid leukaemia (AML) found mutations in IDH1/2 and it is now appreciated that these enzymes (which drive elevated production of D-2-HG) are the most frequently mutated metabolic genes in human cancer112-114.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [113]
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- Authors
- Brabletz, T., Kalluri, R., Nieto, M. A., & Weinberg, R. A.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- The University of Texas MD Anderson Cancer Center (US)
- Consejo Superior de Investigaciones Científicas (ES)
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Brabletz, Thomas
- Kalluri, Raghu
- Nieto, M. Angela
- Weinberg, Robert A.
- Venue
- Nature Reviews Cancer
- Published
- 2018-01-12
- Volume
- 18
- Issue
- 2
- Pages
- 128-134
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2783337717
- Cited by
- 1,961
- References
- 63
- Citations by year
- 2026: 115 · 2025: 169 · 2024: 212 · 2023: 237 · 2022: 276 · 2021: 284 · 2020: 284 · 2019: 264 · 2018: 119
- FWCI
- 25.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- epithelial-mesenchymal transition, cancer, carcinogenesis, cell phenotype, cancer stem cells, future research directions
- MeSH terms
- Humans, Neoplasms, Epithelial-Mesenchymal Transition
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