The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
APOBEC3A can activate the DNA damage response and cause cell‐cycle arrest
Open accessAbstract
Human apolipoprotein‐B mRNA‐editing catalytic polypeptide‐like 3 (APOBEC3) proteins constitute a family of cytidine deaminases that mediate restriction of retroviruses, endogenous retro‐elements and DNA viruses. It is well established that these enzymes are potent mutators of viral DNA, but it is unclear whether their editing activity is a threat to the integrity of the cellular genome. We show that expression of APOBEC3A can lead to induction of DNA breaks and activation of damage responses in a deaminase‐dependent manner. Consistent with these observations, APOBEC3A expression induces cell‐cycle arrest. These results indicate that cellular DNA is vulnerable to APOBEC3 activity and deregulated expression of APOBEC3A could threaten genomic integrity.
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Cites
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
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Metadata
- Authors
- Landry, S., Narvaiza, I., Linfesty, D. C., & Weitzman, M. D.
- Venue
- EMBO reports
- Published
- 2011-04
- Volume
- 12
- Issue
- 5
- Pages
- 444-450
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2149521137
- Cited by
- 229
- References
- 2
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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