The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
Open accessAbstract
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti-inflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of t-RVT has not yet been reported. In this study, we show that t-RVT increases glucose uptake in C2C12 myotubes by activating AMP-activated protein kinase (AMPK), uncovering an antidiabetic potential of t-RVT for the first time. AMPK plays a central role in the regulation of glucose and lipid metabolism, and hence it is considered a novel therapeutic target for metabolic syndrome such as type 2 diabetes. t-RVT significantly induced glucose uptake in C2C12 cells, via AMPK activation, but not a phosphatidylinositol-3 kinase (PI-3 kinase) signal pathway. The induced glucose uptake was attenuated by pretreatment with a pharmacological inhibitor for AMPK, indicating that the effect of t-RVT primarily depends on AMPK activation. However, in the presence of insulin, t-RVT also potentiated the effect of insulin on glucose uptake via AMPK activation, which led to further activation of PI-3 kinase/Akt signal pathway.
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Cites
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053
Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252625599 · Cited by 1,036
Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diabetes.47.8.1369 · Cited by 774
Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310389200 · Cited by 759 · cited 1×
“However, some other reports suggest that AMPK functions upstream of Akt signaling (Ouchi et al., 2004).”
BackgroundJakobsen, S. N., Hardie, D. G., Morrice, N., & Tornqvist, H. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100483200 · Cited by 238 · cited 1×
“In fact, AMPK has been reported to lead to the phosphorylation of insulin receptor substrate-1 on Ser 789 in C2C12 myotubes when exposed to AICAR, a known AMPK activator (Jakobsen et al., 2001).”
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Cited by
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,637
Impact of Dietary Polyphenols on Carbohydrate Metabolism
Hanhineva, K., Törrönen, R., Bondia-Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H., & Poutanen, K. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041365 · Cited by 1,157
AMPK activators: mechanisms of action and physiological activities
Kim, J., Yang, G., Kim, Y., Kim, J., & Ha, J. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.16 · Cited by 817
Self-citationDietary polyphenols as potential nutraceuticals in management of diabetes: a review
Bahadoran, Z., Mirmiran, P., & Azizi, F. (2013) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-12-43 · Cited by 594
Healthy Effects of Plant Polyphenols: Molecular Mechanisms
Leri, M., Scuto, M., Ontario, M. L., Calabrese, V., Calabrese, E. J., Bucciantini, M., & Stefani, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041250 · Cited by 435
Metadata
- Authors
- Park, C. E., Kim, M.-J., Lee, J. H., Min, B.-I., Bae, H., Choe, W., Kim, S.-S., & Ha, J.
- Venue
- Experimental & Molecular Medicine
- Published
- 2007-04-01
- Volume
- 39
- Issue
- 2
- Pages
- 222-229
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2075763304
- Cited by
- 239
- References
- 7
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Park, C. E., Kim, M.-J., Lee, J. H., Min, B.-I., Bae, H., Choe, W., Kim, S.-S., & Ha, J. (2007). Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Experimental & Molecular Medicine. https://doi.org/10.1038/emm.2007.25
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