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Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Open accessAbstract
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in several kinds of human tumors, the function of COX-2 in osteosarcoma is unclear. Therefore, to investigate the function of COX-2 in osteosarcoma, we established stable cell lines overexpressing COX-2 in U2OS human osteosarcoma cells. COX-2 overexpression as well as prostaglandin E2 treatment promoted proliferation of U2OS cells. In addition, COX-2 overexpression enhanced mobility and invasiveness of U2OS cells, which was accompanied by increases of matrix metalloproteinase-2 and -9 (MMP-2 and -9) activities. Selective COX-2 inhibitors, NS-398 and celecoxib, inhibited cell proliferation and abrogated the enhanced mobility, invasiveness and MMP activities induced by COX-2 overexpression. These results suggest that COX-2 is directly associated with cell proliferation, migration and invasion in human osteosarcoma cells, and the therapeutic value of COX-2 inhibitors should be evaluated continuously.
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COX/PTGS enzymes are typically induced in response to inflammation in vivo and are not found to be expressed in U2OS cells according to the Human Protein Atlas database.
“Since COX/PTGS enzymes are typically induced in response to inflammation in vivo46 and are not found to be expressed in U2OS cells according to the Human Protein Atlas database (https://www.proteinatlas.org/ENSG00000095303-PTGS1/cell+line), this compound is not expected to show strong and specific phenotypic responses in this cell model (Fig. 7d).”
From A statistical framework for high-content phenotypic profiling using cellular feature distributions (2022) · cites this paper as [46]
The Introduction says COX-2 expression is induced by various stimuli, but does not specify inflammation in vivo or extend that statement to COX/PTGS enzymes generally. The U2OS expression claim is attributed separately to the Human Protein Atlas URL, not to this paper. (LLM, conf=0.82)
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“Since COX/PTGS enzymes are typically induced in response to in fl ammation in vivo 46 and are not found to be expressed in U2OS cells according to the Human Protein Atlas database (https://www.proteinatlas.org/ ENSG00000095303-PTGS1/cell + line), this compound is not expected to show strong and…”
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Metadata
- Authors
- Lee, E. J., Choi, E. M., Kim, S. R., Park, J. H., Kim, H., Ha, K. S., Kim, Y. M., Kim, S. S., Choe, M., Kim, J.-I., & Han, J. A.
- Affiliations
- Kangwon National University (KR)
- Seoul National University (KR)
- Corresponding author
- Han, Jeong A
- Venue
- Experimental & Molecular Medicine
- Published
- 2007-08-01
- Volume
- 39
- Issue
- 4
- Pages
- 469-476
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2078935333
- Cited by
- 80
- References
- 24
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Ministry of Education and Human Resources Development
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- cyclooxygenase-2, osteosarcoma, U2OS cells, cell proliferation, cell migration, cell invasion, prostaglandin E2, MMP-2, MMP-9, COX-2 inhibitors, celecoxib, NS-398, metastasis
- MeSH terms
- Celecoxib, Bone Neoplasms, Cell Movement, Enzyme Activation, Humans, Neoplasm Invasiveness, Nitrobenzenes, Pyrazoles, Osteosarcoma, Sulfonamides, Dinoprostone, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Cell Line, Tumor, Cell Proliferation, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors
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