Cited by 139Prenatal Screening and DiagnosticsEthics and Legal Issues in Pediatric HealthcareSexual Differentiation and Disorders

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Decision to abort after a prenatal diagnosis of sex chromosome abnormality: a systematic review of the literature

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Jeon, Kwon Chan, Chen, Lei-Shih, Goodson, Patricia·2012·Genetics in Medicine

DOI 10.1038/gim.0b013e31822e57a7

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Abstract

We performed a systematic review of factors affecting parental decisions to continue or terminate a pregnancy after prenatal diagnosis of a sex chromosome abnormality, as reported in published studies from 1987 to May 2011. Based on the Matrix Method for systematic reviews, 19 studies were found in five electronic databases, meeting specific inclusion/exclusion criteria. Abstracted data were organized in a matrix. Alongside the search for factors influencing parental decisions, each study was judged on its methodological quality and assigned a methodological quality score. Decisions either to terminate or to continue a sex chromosome abnormality-affected pregnancy shared five similar factors: specific type of sex chromosome abnormality, gestational week at diagnosis, parents' age, providers' genetic expertise, and number of children/desire for (more) children. Factors unique to termination decisions included parents' fear/anxiety and directive counseling. Factors uniquely associated with continuation decisions were parents' socioeconomic status and ethnicity. The studies' average methodological quality score was 10.6 (SD = 1.67; range, 8-14). Findings from this review can be useful in adapting and modifying guidelines for genetic counseling after prenatal diagnosis of a sex chromosome abnormality. Moreover, improving the quality of future studies on this topic may allow clearer understanding of the most influential factors affecting parental decisions.

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Authors: Jeon, K. C., Chen, L.-S., & Goodson, P.
Affiliations: Texas A&M University (US)
Corresponding author: Jeon, Kwon Chan
ORCID: Chen, Lei-Shih
Goodson, Patricia
Venue: Genetics in Medicine
Publisher: Elsevier BV
Published: 2012-01
Volume: 14
Issue: 1
Pages: 27-38
ISSN: 1098-3600 (ISSN-L)
DOI: 10.1038/gim.0b013e31822e57a7
OpenAlex: W2091333572
Cited by: 139
References: 39
Citations by year: 2026: 3 · 2025: 21 · 2024: 10 · 2023: 4 · 2022: 13 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 37 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 7
FWCI: 1.25
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3671 d)
Locations: Genetics in Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Ethics and Legal Issues in Pediatric Healthcare
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: sex chromosome abnormalities, prenatal diagnosis, abortion, continuation of pregnancy, parental decision-making, genetic counseling, gestational age at diagnosis, parental age, socioeconomic status, ethnicity, fear and anxiety, desire for more children
MeSH terms: Abortion, Induced, Decision Making, Female, Humans, Parents, Pregnancy, Pregnancy Outcome, Prenatal Diagnosis, Sex Chromosome Aberrations

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Decision to abort after a prenatal diagnosis of sex chromosome abnormality: a systematic review of the literature

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