The DOI matches its Crossref record; 86 of the 87 references it cites were found in a registry or an index.
Integrase-defective lentiviral vectors: progress and applications
Abstract
Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term expression from integrated gene cassettes. However, transgene integration carries a risk of disrupting gene expression through insertional mutagenesis and may not be required for all applications. A non-integrating LV may be beneficial in cases in which transient gene expression is desired. Several recent publications outline the development and initial biological characterization of such vectors. Here, we discuss the potential applications and new directions for the development of integration-defective LVs.
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“In contrast, class I mutations are limited in affecting the integrase multimerisation, linear episome processing, and DNA binding [25], as listed in Table 3.”
From Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through (2022) · cites this paper as [25]
In the citing paper
“Class II mutations can be performed by exchanging the standard gag or pol packaging plasmid with an IN mutant strain [25].”
From Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through (2022) · cites this paper as [25]
Citations
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Metadata
- Authors
- Banasik, M. B., & McCray, P. B.
- Affiliations
- University of Iowa (US)
- Corresponding author
- McCray, P B
- ORCID
- McCray, P B
- Venue
- Gene Therapy
- Published
- 2009-10-22
- Volume
- 17
- Issue
- 2
- Pages
- 150-157
- ISSN
- 0969-7128 (ISSN-L)
- 1476-5462
- OpenAlex
- W1964810194
- Cited by
- 129
- References
- 87
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 16 · 2013: 8 · 2012: 17
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- lentiviral vectors, non-integrating vectors, insertional mutagenesis, transient expression, pseudotyping, cell tropism, gene therapy vectors
- MeSH terms
- Animals, Genetic Vectors, Genetic Therapy, Gene Expression, Lentivirus, Mutagenesis, Insertional, Virus Integration, Gene Transfer Techniques, Transgenes, Integrases
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