Cited by 129Virus-based gene therapy researchRNA Interference and Gene DeliveryViral Infectious Diseases and Gene Expression in Insects

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Integrase-defective lentiviral vectors: progress and applications

Banasik, M B, McCray, P B·2010·Gene Therapy

DOI 10.1038/gt.2009.135

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Abstract

Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term expression from integrated gene cassettes. However, transgene integration carries a risk of disrupting gene expression through insertional mutagenesis and may not be required for all applications. A non-integrating LV may be beneficial in cases in which transient gene expression is desired. Several recent publications outline the development and initial biological characterization of such vectors. Here, we discuss the potential applications and new directions for the development of integration-defective LVs.

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Authors: Banasik, M. B., & McCray, P. B.
Affiliations: University of Iowa (US)
Corresponding author: McCray, P B
ORCID: McCray, P B
Venue: Gene Therapy
Publisher: Springer Science and Business Media LLC
Published: 2009-10-22
Volume: 17
Issue: 2
Pages: 150-157
ISSN: 0969-7128 (ISSN-L)
1476-5462
DOI: 10.1038/gt.2009.135
OpenAlex: W1964810194
Cited by: 129
References: 87
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 16 · 2013: 8 · 2012: 17
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Gene Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Keywords: lentiviral vectors, non-integrating vectors, insertional mutagenesis, transient expression, pseudotyping, cell tropism, gene therapy vectors
MeSH terms: Animals, Genetic Vectors, Genetic Therapy, Gene Expression, Lentivirus, Mutagenesis, Insertional, Virus Integration, Gene Transfer Techniques, Transgenes, Integrases

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