Cited by 129Virus-based gene therapy researchRNA Interference and Gene DeliveryViral Infectious Diseases and Gene Expression in Insects

The DOI matches its Crossref record; 86 of the 87 references it cites were found in a registry or an index.

Integrase-defective lentiviral vectors: progress and applications

Banasik, M B, McCray, P B·2010·Gene Therapy

DOI 10.1038/gt.2009.135

Open this paper in CoChat — free account

Abstract

Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term expression from integrated gene cassettes. However, transgene integration carries a risk of disrupting gene expression through insertional mutagenesis and may not be required for all applications. A non-integrating LV may be beneficial in cases in which transient gene expression is desired. Several recent publications outline the development and initial biological characterization of such vectors. Here, we discuss the potential applications and new directions for the development of integration-defective LVs.

Integrity signals

Registry

Crossref · 10.1038/gt.2009.135

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1
Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., et al. (2003) · Science · doi:10.1126/science.1088547 · Cited by 3,587
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
Hacein-Bey-Abina, S., von Kalle, C., Schmidt, M., Le Deist, F., Wulffraat, N., McIntyre, E., Radford, I., Villeval, J.-L., Fraser, C. C., Cavazzana-Calvo, M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejm200301163480314 · Cited by 1,867
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
Hacein-Bey-Abina, S., Garrigue, A., Wang, G. P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35700 · Cited by 1,854
HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
Schröder, A. R. W., Shinn, P., Chen, H., Berry, C., Ecker, J. R., & Bushman, F. (2002) · Cell · doi:10.1016/s0092-8674(02)00864-4 · Cited by 1,832
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499
Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration
Wu, X., Li, Y., Crise, B., & Burgess, S. M. (2003) · Science · doi:10.1126/science.1083413 · Cited by 1,305
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Howe, S. J., Mansour, M. R., Schwarzwaelder, K., Bartholomae, C., Hubank, M., Kempski, H., Brugman, M. H., Pike-Overzet, K., Chatters, S. J., de Ridder, D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35798 · Cited by 1,286
Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy
Hacein‐Bey‐Abina, S., Deist, F. L., Carlier, F., Bouneaud, C., Hue, C., de Villartay, J., Thrasher, A. J., Wulffraat, N. M., Sorensen, R., Dupuis‐Girod, S., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012616 · Cited by 1,102
Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences
Mitchell, R., Beitzel, B. F., Schröder, A. R. W., Shinn, P., Chen, H., Berry, C. C., Ecker, J. R., & Bushman, F. D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020234 · Cited by 1,002
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Lombardo, A., Genovese, P., Beausejour, C. M., Colleoni, S., Lee, Y.-L., Kim, K. A., Ando, D., Urnov, F. D., Galli, C., Gregory, P. D., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1353 · Cited by 845
Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification
Maeder, M. L., Thibodeau-Beganny, S., Osiak, A., Wright, D. A., Anthony, R. M., Eichtinger, M., Jiang, T., Foley, J. E., Winfrey, R. J., Townsend, J. A., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.016 · Cited by 727
Self-citation
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
Montini, E., Cesana, D., Schmidt, M., Sanvito, F., Bartholomae, C. C., Ranzani, M., Benedicenti, F., Sergi, L. S., Ambrosi, A., Ponzoni, M., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37630 · Cited by 571
Residues Critical for Retroviral Integrative Recombination in a Region That Is Highly Conserved among Retroviral/Retrotransposon Integrases and Bacterial Insertion Sequence Transposases
Kulkosky, J., Jones, K. S., Katz, R. A., Mack, J. P. G., & Skalka, A. M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2331 · Cited by 567
THE RETROVIRAL ENZYMES
Katz, R. A., & Skalka, A. M. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.001025 · Cited by 524
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
Engelman, A., & Craigie, R. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6361-6369.1992 · Cited by 519
Effective gene therapy with nonintegrating lentiviral vectors
Yáñez-Muñoz, R. J., Balaggan, K. S., MacNeil, A., Howe, S. J., Schmidt, M., Smith, A. J., Buch, P., MacLaren, R. E., Anderson, P. N., Barker, S. E., et al. (2006) · Nature Medicine · doi:10.1038/nm1365 · Cited by 460
HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
Wang, G. P., Ciuffi, A., Leipzig, J., Berry, C. C., & Bushman, F. D. (2007) · Genome Research · doi:10.1101/gr.6286907 · Cited by 457
Systematic Determination of the Packaging Limit of Lentiviral Vectors
Kumar, M., Keller, B. C., Makalou, N., & Sutton, R. E. (2001) · Human Gene Therapy · doi:10.1089/104303401753153947 · Cited by 456
Inhibition of influenza virus production in virus-infected mice by RNA interference
Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H. N., & Chen, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402486101 · Cited by 443
The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro
Craigie, R., Fujiwara, T., & Bushman, F. (1990) · Cell · doi:10.1016/0092-8674(90)90126-y · Cited by 409
Role of the non‐homologous DNA end joining pathway in the early steps of retroviral infection
Li, L., Olvera, J. M., Yoder, K., Mitchell, R., Butler, S., Lieber, M., Martin, S. L., & Bushman, F. D. (2001) · EMBO Journal · doi:10.1093/emboj/20.12.3272 · Cited by 386
Nucleotide sequence and genomic organization of feline immunodeficiency virus.
Talbott, R. L., Sparger, E. E., Lovelace, K., Fitch, W. M., Pedersen, N. C., Luciw, P. A., & Elder, J. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5743 · Cited by 383
Gene Therapy Progress and Prospects: Development of improved lentiviral and retroviral vectors – design, biosafety, and production
Sinn, P., Sauter, S., & McCray, P. B. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302570 · Cited by 351
Self-citation
Identification of discrete functional domains of HIV‐1 integrase and their organization within an active multimeric complex.
Engelman, A., Bushman, F. D., & Craigie, R. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05996.x · Cited by 350
The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
Katz, R. A., Merkel, G., Kulkosky, J., Leis, J., & Skalka, A. M. (1990) · Cell · doi:10.1016/0092-8674(90)90290-u · Cited by 346
Retroviral integrase domains: DNA binding and the recognition of LTR sequences
Khan, E., Mack, J. P. G., Katz, R. A., Kulkosky, J., & Skalka, A. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.4.851 · Cited by 287
HIV Integrase, a Brief Overview from Chemistry to Therapeutics*
Craigie, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100027200 · Cited by 277
Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells
Wiskerchen, M. A., & Muesing, M. A. (1995) · Journal of Virology · doi:10.1128/jvi.69.1.376-386.1995 · Cited by 271
The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding
Engelman, A., Hickman, A. B., & Craigie, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.9.5911-5917.1994 · Cited by 250
Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo
Philippe, S., Sarkis, C., Barkats, M., Mammeri, H., Ladroue, C., Petit, C., Mallet, J., & Serguera, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606197103 · Cited by 249
Human Immunodeficiency Virus cDNA Metabolism: Notable Stability of Two-Long Terminal Repeat Circles
Butler, S. L., Johnson, E. P., & Bushman, F. D. (2002) · Journal of Virology · doi:10.1128/jvi.76.8.3739-3747.2002 · Cited by 237
Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo
Chen, Z. Y., He, C. Y., Meuse, L. A., & Kay, M. A. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302231 · Cited by 232
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection
Leavitt, A. D., Robles, G., Alesandro, N., & Varmus, H. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.721-728.1996 · Cited by 232
Early steps of retrovirus replicative cycle
Nisole, S., & Saı̈b, A. (2004) · Retrovirology · doi:10.1186/1742-4690-1-9 · Cited by 230
Repair of gaps in retroviral DNA integration intermediates
Yoder, K. E., & Bushman, F. D. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11191-11200.2000 · Cited by 209
Integration is not necessary for expression of human immunodeficiency virus type 1 protein products
Stevenson, M., Haggerty, S., Lamonica, C. A., Meier, C. M., Welch, S. K., & Wasiak, A. (1990) · Journal of Virology · doi:10.1128/jvi.64.5.2421-2425.1990 · Cited by 206
Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in Vitro
Drelich, M., Wilhelm, R., & Mous, J. (1992) · Virology · doi:10.1016/0042-6822(92)90499-f · Cited by 206
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.
Leavitt, A. D., Shiue, L., & VARMUS, H. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53969-7 · Cited by 200
Transient Gene Expression by Nonintegrating Lentiviral Vectors
Nightingale, S. J., Hollis, R. P., Pepper, K. A., Petersen, D., Yu, X.-J., Yang, C., Bahner, I., & Kohn, D. B. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.008 · Cited by 192
Intrinsic Stability of Episomal Circles Formed during Human Immunodeficiency Virus Type 1 Replication
Pierson, T. C., Kieffer, T. L., Ruff, C. T., Buck, C. B., Gange, S. J., & Siliciano, R. F. (2002) · Journal of Virology · doi:10.1128/jvi.76.8.4138-4144.2002 · Cited by 184
Stable Gene Transfer to Muscle Using Non-integrating Lentiviral Vectors
Apolonia, L., Waddington, S. N., Fernandes, C., Ward, N. J., Bouma, G., Blundell, M. P., Thrasher, A. J., Collins, M. K., & Philpott, N. J. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300281 · Cited by 174
Therapeutic levels of human factor VIII and IX using HIV-1–based lentiviral vectors in mouse liver
Park, F., Ohashi, K., & Kay, M. A. (2000) · Blood · doi:10.1182/blood.v96.3.1173 · Cited by 157
Polynucleotidyl transfer reactions in transpositional DNA recombination.
Mizuuchi, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36600-1 · Cited by 155
A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro.
Ellison, V., & Brown, P. O. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7316 · Cited by 154
Circularization of human immunodeficiency virus type 1 DNA in vitro
Farnet, C. M., & Haseltine, W. A. (1991) · Journal of Virology · doi:10.1128/jvi.65.12.6942-6952.1991 · Cited by 148
Novel Integrase-Defective Lentiviral Episomal Vectors for Gene Transfer
Vargas, J., Gusella, G. L., Najfeld, V., Klotman, M., & Cara, A. (2004) · Human Gene Therapy · doi:10.1089/104303404322959515 · Cited by 132
An Essential Interaction between Distinct Domains of HIV-1 Integrase Mediates Assembly of the Active Multimer
Ellison, V., Gerton, J. L., Vincent, K. A., & Brown, P. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.3320 · Cited by 131
Retroviral vectors: new applications for an old tool
Barquinero, J., Eixarch, H., & Pérez-Melgosa, M. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302363 · Cited by 127
Structure-Based Mutational Analysis of the C-Terminal DNA-Binding Domain of Human Immunodeficiency Virus Type 1 Integrase: Critical Residues for Protein Oligomerization and DNA Binding
Lutzke, R. A. P., & Plasterk, R. H. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.4841-4848.1998 · Cited by 124
HIV-1 gene expression: lessons from provirus and non-integrated DNA
Wu, Y. (2004) · Retrovirology · doi:10.1186/1742-4690-1-13 · Cited by 124
Unintegrated Lentivirus DNA Persistence and Accessibility to Expression in Nondividing Cells: Analysis with Class I Integrase Mutants
Saenz, D. T., Loewen, N. A., Peretz, M., Whitwam, T., Barraza, R., Howell, K. G., Holmes, J. M., Good, M. S., & Poeschla, E. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.6.2906-2920.2004 · Cited by 122
Intramolecular integration within Moloney murine leukemia virus DNA
Shoemaker, C. B., Hoffman, J., Goff, S. P., & Baltimore, D. (1981) · Journal of Virology · doi:10.1128/jvi.40.1.164-172.1981 · Cited by 121
Gene Silencing by Small Regulatory RNAs in Mammalian Cells
Scherr, M., & Eder, M. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3807 · Cited by 117
Erratum: Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy (New England Journal of Medicine (April 18, 2002) 346 (1185-1193))
Hacein‐Bey‐Abina, S., Deist, F. L., Carlier, F., Bouneaud, C., Hue, C., Villartay, J. D., Thrasher, A. J., Wulffraat, N. M., Sorensen, R. J. D., Dupuis‐Girod, S., et al. (2002) · UCL Discovery (University College London) · Cited by 117
Human Immunodeficiency Virus Type 1 Replication in the Absence of Integrase-Mediated DNA Recombination: Definition of Permissive and Nonpermissive T-Cell Lines
Nakajima, N., Lu, R., & Engelman, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.17.7944-7955.2001 · Cited by 113
CCR5: no longer a ‘good for nothing’ gene – chemokine control of West Nile virus infection
Lim, J. K., Glass, W. G., McDermott, D. H., & Murphy, P. M. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.05.007 · Cited by 112
Targeted Genome Modifications Using Integrase-deficient Lentiviral Vectors
Cornu, T. I., & Cathomen, T. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300345 · Cited by 105
Retrovirus Vectors: Toward the Plentivirus?
Baum, C., Schambach, A., Bohne, J., & Galla, M. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.007 · Cited by 103
Minicircle‐DNA production by site specific recombination and protein–DNA interaction chromatography
Mayrhofer, P., Blaesen, M., Schleef, M., & Jechlinger, W. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1243 · Cited by 102
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors
Rahim, A. A., Wong, A. M. S., Howe, S. J., Buckley, S. M. K., Acosta-Saltos, A. D., Elston, K. E., Ward, N. J., Philpott, N. J., Cooper, J. D., Anderson, P. N., et al. (2009) · Gene Therapy · doi:10.1038/gt.2008.186 · Cited by 101
Purification of retroviral vectors for clinical application: Biological implications and technological challenges
Rodrigues, T., Carrondo, M. J. T., Alves, P. M., & Cruz, P. E. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.07.028 · Cited by 98
Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro
Miller, M. D., Wang, B., & Bushman, F. D. (1995) · Journal of Virology · doi:10.1128/jvi.69.6.3938-3944.1995 · Cited by 96
Hybrid Lentivirus-transposon Vectors with a Random Integration Profile in Human Cells
Staunstrup, N. H., Moldt, B., Mátés, L., Villesen, P., Jakobsen, M., Ivics, Z., Izsvák, Z., & Mikkelsen, J. G. (2009) · Molecular Therapy · doi:10.1038/mt.2009.10 · Cited by 96
A Large U3 Deletion Causes Increased In Vivo Expression from a Nonintegrating Lentiviral Vector
Bayer, M., Kantor, B., Cockrell, A., Ma, H., Zeithaml, B., Li, X., McCown, T., & Kafri, T. (2008) · Molecular Therapy · doi:10.1038/mt.2008.199 · Cited by 94
Evidence for Gene Expression by Unintegrated Human Immunodeficiency Virus Type 1 DNA Species
Brussel, A., & Sonigo, P. (2004) · Journal of Virology · doi:10.1128/jvi.78.20.11263-11271.2004 · Cited by 93
Genetic Analyses of DNA-Binding Mutants in the Catalytic Core Domain of Human Immunodeficiency Virus Type 1 Integrase
Lu, R., Limón, A., Ghory, H. Z., & Engelman, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2493-2505.2005 · Cited by 92
Successful Immunization with a Single Injection of Non-integrating Lentiviral Vector
Negri, D. R., Michelini, Z., Baroncelli, S., Spada, M., Vendetti, S., Buffa, V., Bona, R., Leone, P., Klotman, M. E., & Cara, A. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300241 · Cited by 84
2-LTR Circular Viral DNA as a Marker for Human Immunodeficiency Virus Type 1 Infection in Vivo
Pauza, C. D., Trivedi, P., McKechnie, T. S., Richman, D. D., & Graziano, F. M. (1994) · Virology · doi:10.1006/viro.1994.1667 · Cited by 81
Sleeping Beauty Transposition From Nonintegrating Lentivirus
Vink, C. A., Gaspar, H. B., Gabriel, R., Schmidt, M., McIvor, R. S., Thrasher, A. J., & Qasim, W. (2009) · Molecular Therapy · doi:10.1038/mt.2009.94 · Cited by 76
Central Core Domain of Retroviral Integrase Is Responsible for Target Site Selection
hio Shibagaki, Y., & Chow, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8361 · Cited by 73
Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine
Coutant, F., Frenkiel, M.-P., Despres, P., & Charneau, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003973 · Cited by 70
Expressing short hairpin RNAs in vivo
Snøve, O., & Rossi, J. J. (2006) · Nature Methods · doi:10.1038/nmeth927 · Cited by 64
The MDS1–EVI1 Gene Complex as a Retrovirus Integration Site: Impact on Behavior of Hematopoietic Cells and Implications for Gene Therapy
Métais, J., & Dunbar, C. E. (2008) · Molecular Therapy · doi:10.1038/sj.mt.6300372 · Cited by 64
Rational Vector Design for Efficient Non-viral Gene Delivery: Challenges Facing the Use of Plasmid DNA
Mairhofer, J., & Grabherr, R. M. (2008) · Molecular Biotechnology · doi:10.1007/s12033-008-9046-7 · Cited by 63
Toolbox for retrovectorologists
Pagès, J., & Bru, T. (2004) · Journal of Gene Medicine · doi:10.1002/jgm.498 · Cited by 60
RNA Interference: A Tool for Querying Nervous System Function and an Emerging Therapy
Davidson, B. L., & Boudreau, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.020 · Cited by 56
Integration Site Choice of a Feline Immunodeficiency Virus Vector
Kang, Y.-B., Moressi, C. J., Scheetz, T., Xie, L.-T., Tran, D., Casavant, T., Ak, P., Benham, C., Davidson, B., & McCray, P. (2006) · Journal of Virology · doi:10.1128/jvi.00719-06 · Cited by 53
Self-citation
Mutations in the Human Immunodeficiency Virus Type 1 Integrase D,D(35)E Motif Do Not Eliminate Provirus Formation
Gaur, M., & Leavitt, A. D. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.4678-4685.1998 · Cited by 52
Characterization of Feline Immunodeficiency Virus Integrase and Analysis of Functional Domains
Shibagaki, Y., Holmes, M. L., Appa, R. S., & Chow, S. A. (1997) · Virology · doi:10.1006/viro.1997.8466 · Cited by 50
Identification of amino acids in HIV-2 integrase involved in site-specific hydrolysis and alcoholysis of viral DNA termini
van Gent, D. C., Groeneger, A. A. M. O., & Plasterk, R. H. A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.15.3373 · Cited by 50
Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase
Moldt, B., Staunstrup, N. H., Jakobsen, M., Yáñez-Muñoz, R. J., & Mikkelsen, J. G. (2008) · BMC Biotechnology · doi:10.1186/1472-6750-8-60 · Cited by 44
Comparison of wild‐type and class I integrase mutant‐FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium
Loewen, N. A., Leske, D. A., Chen, Y., Teo, W., Saenz, D. T., Peretz, M., Holmes, J. M., & Poeschla, E. M. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.447 · Cited by 36
Targeted gene modification in mouse ES cells using integrase‐defective lentiviral vectors
Okada, Y., Ueshin, Y., Hasuwa, H., Takumi, K., Okabe, M., & Ikawa, M. (2009) · genesis · doi:10.1002/dvg.20469 · Cited by 24
Transient gene expression mediated by integrase-defective retroviral vectors.
Yu, S.-S., Dan, K., Chono, H., Chatani, E., Mineno, J., & Kato, I. (2008) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2008.02.012 · Cited by 18
Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy.
Vargas, J. J., Klotman, M., & Cara, A. (2008) · Antiviral Research · doi:10.1016/j.antiviral.2008.06.015 · Cited by 17
Unintegrated viral DNA as a marker for human immunodeficiency virus 1 infection in vivo and in vitro.
Js, N. (1999) · PubMed · Cited by 3

Research works printed but not linked: 2

Goff SP . Retroviridae: the retroviruses and their replication. In: David M Knipe PMH, Diane E Griffin, Malcolm A Martin, Robert A Lamb, Bernard Roizman, Stephen E Strauss (ed). Fields Virology, 4th edn, vol. 2. Lippincott Williams & Wilkins: Philadelphia, 2001. pp 1871–1940.
Lombardo A, Cesana D, Genovese P, Provasi E, Maruggi G, Binini C et al. Characterization of potential genomic ‘safe harbor’ for efficient targeted gene addition with zinc finger nucleases. Mol Ther 2009; 17: S168.

Sorted by citations

Recent Advances in CRISPR/Cas9 Delivery Strategies
Yip, B. (2020) · Biomolecules · doi:10.3390/biom10060839 · Cited by 292
Gene therapy on the move
Kaufmann, K. B., Büning, H., Galy, A. H. M., Schambach, A., & Grez, M. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202287 · Cited by 300
Engineering mesenchymal stem cells for regenerative medicine and drug delivery
Park, J. S., Suryaprakash, S., Lao, Y., & Leong, K. W. (2015) · Methods · doi:10.1016/j.ymeth.2015.03.002 · Cited by 252
Improving the safety of cell therapy products by suicide gene transfer
Jones, B. S., Lamb, L. S., Goldman, F. D., & Stasi, A. D. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00254 · Cited by 206
The role of unintegrated DNA in HIV infection
Sloan, R. D., & Wainberg, M. A. (2011) · Retrovirology · doi:10.1186/1742-4690-8-52 · Cited by 155

See all 129

Authors: Banasik, M. B., & McCray, P. B.
Affiliations: University of Iowa (US)
Corresponding author: McCray, P B
ORCID: McCray, P B
Venue: Gene Therapy
Publisher: Springer Science and Business Media LLC
Published: 2009-10-22
Volume: 17
Issue: 2
Pages: 150-157
ISSN: 0969-7128 (ISSN-L)
1476-5462
DOI: 10.1038/gt.2009.135
OpenAlex: W1964810194
Cited by: 129
References: 87
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 16 · 2013: 8 · 2012: 17
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Gene Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Keywords: lentiviral vectors, non-integrating vectors, insertional mutagenesis, transient expression, pseudotyping, cell tropism, gene therapy vectors
MeSH terms: Animals, Genetic Vectors, Genetic Therapy, Gene Expression, Lentivirus, Mutagenesis, Insertional, Virus Integration, Gene Transfer Techniques, Transgenes, Integrases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Integrase-defective lentiviral vectors: progress and applications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks